{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T14:33:12Z","timestamp":1783348392661,"version":"3.54.6"},"reference-count":11,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2012,5,25]],"date-time":"2012-05-25T00:00:00Z","timestamp":1337904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p>Objective: To investigate the predictive value of serum C3 and C4 complement component levels in relation to pregnancy outcome in patients with antiphospholipid syndrome (APS).<\/jats:p>\n                  <jats:p>Materials and methods: A prospective study of 47 pregnancies associated with APS was performed. Pregnancy outcome was analyzed in terms of: fetal loss, preterm delivery (\u226434 gestational weeks), fetal intrauterine growth restriction (IUGR), birth weight &lt;2500\u2009g and preeclampsia. Week at delivery, neonatal birth weight and neonatal birth weight percentile were also investigated. Hypocomplementemia, positivity for anti-dsDNA and triple positivity for antiphospholipid antibodies (aPL) were related to pregnancy outcome.<\/jats:p>\n                  <jats:p>Results: Forty-three pregnancies ended in live births with a fetal loss rate of 8.5%. Fetal death, preterm delivery and birth weight &lt;2500\u2009g were associated with hypocomplementemia ( p\u2009=\u20090.019, p\u2009=\u20090.0002, p\u2009&lt;\u20090.0001 respectively). Lower neonatal birth weight, lower neonatal birth weight percentile and lower week at delivery were associated with hypocomplementemia ( p\u2009&lt;\u20090.0001, p\u2009=\u20090.0003, p\u2009&lt;\u20090.0001 respectively) and with triple aPL positivity ( p\u2009=\u20090.008, p\u2009=\u20090.014, p\u2009=\u20090.03 respectively). A poor pregnancy outcome was confirmed among primary APS (PAPS) pregnancies with hypocomplementemia. Multivariate analysis confirmed that hypocomplementemia was an independent predictor of lower neonatal birth weight ( p\u2009=\u20090.0001) and lower week at delivery ( p\u2009=\u20090.002).<\/jats:p>\n                  <jats:p>Conclusion: Hypocomplementemia could be considered a novel prognostic factor for pregnancy outcome in APS patients.<\/jats:p>","DOI":"10.1177\/0961203312444172","type":"journal-article","created":{"date-parts":[[2012,5,25]],"date-time":"2012-05-25T12:47:56Z","timestamp":1337950076000},"page":"776-778","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":50,"title":["Complementemia and obstetric outcome in pregnancy with antiphospholipid syndrome"],"prefix":"10.1177","volume":"21","author":[{"given":"S","family":"De Carolis","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Catholic University of Sacred Heart, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Botta","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Catholic University of Sacred Heart, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Santucci","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Catholic University of Sacred Heart, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Salvi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Catholic University of Sacred Heart, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Moresi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Catholic University of Sacred Heart, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Di Pasquo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Catholic University of Sacred Heart, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Del Sordo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Catholic University of Sacred Heart, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Martino","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Catholic University of Sacred Heart, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,5,25]]},"reference":[{"key":"bibr1-0961203312444172","doi-asserted-by":"publisher","DOI":"10.1084\/jem.200116116"},{"key":"bibr2-0961203312444172","doi-asserted-by":"publisher","DOI":"10.1002\/art.21157"},{"key":"bibr3-0961203312444172","doi-asserted-by":"crossref","unstructured":"De Carolis S, Botta A, Santucci S,\n                      et al\n                      . Predictors of pregnancy outcome in antiphospholipid syndrome: a review.\n                      Clin Rev Allergy Immunol\n                      2010; 38: 116\u2013124.","DOI":"10.1007\/s12016-009-8144-z"},{"key":"bibr4-0961203312444172","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.01753.x"},{"key":"bibr5-0961203312444172","doi-asserted-by":"publisher","DOI":"10.1191\/0961203303lu393oa"},{"key":"bibr6-0961203312444172","doi-asserted-by":"publisher","DOI":"10.1177\/0961203310361350"},{"key":"bibr7-0961203312444172","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1422.056"},{"key":"bibr8-0961203312444172","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.100746"},{"key":"bibr9-0961203312444172","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20098"},{"key":"bibr10-0961203312444172","first-page":"235","volume":"98","author":"Venkat-Raman N","year":"2001","journal-title":"Obstet Gynecol"},{"key":"bibr11-0961203312444172","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kei159"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203312444172","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0961203312444172","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203312444172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:12:17Z","timestamp":1777677137000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0961203312444172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,25]]},"references-count":11,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["10.1177\/0961203312444172"],"URL":"https:\/\/doi.org\/10.1177\/0961203312444172","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,25]]}}}