{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:00:09Z","timestamp":1777928409159,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2012,6,8]],"date-time":"2012-06-08T00:00:00Z","timestamp":1339113600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p>Background: Urinary intercellular adhesion molecule-1 (ICAM-1) level is potentially a valuable biomarker of lupus nephritis (LN), but because ICAM-1 is a cell-surface molecule, soluble ICAM-1 level in urinary supernatant measured by ELISA may not be biologically relevant. Methods: The ICAM-1 level in urine sediment of 12 LN patients, 10 patients with pauci-immune necrotizing glomerulonephritis (NecGN), and six healthy controls were determined with a polymerase chain reaction (PCR)-based assay. The urinary sediment levels of miR-221, miR-222, miR-339-3P and miR-339-5P, which are involved in the regulation of ICAM-1 production, were also quantified. Results: LN patients had lower urinary sediment ICAM-1 levels than the other two groups (overall p\u2009=\u20090.034). In addition, urinary sediment ICAM-1 level inversely correlated with the estimated glomerular filtration rate (GFR) ( r\u2009=\u2009\u22120.474, p\u2009=\u20090.026) but not other markers of lupus activity, or urinary sediment levels of miR-221, miR-222, miR-339-3P, or miR-339-5P. However, serum anti-dsDNA level inversely correlated with urinary sediment levels of miR-221 ( r\u2009=\u2009\u22120.591, p\u2009=\u20090.043) and miR-222 ( r\u2009=\u2009\u22120.689, p\u2009=\u20090.013), while urinary sediment miR-221 level also correlated with serum C3 level ( r\u2009=\u20090.658, p\u2009=\u20090.02). Conclusions: We conclude that urinary sediment ICAM-1 level was significantly reduced in LN, and the level inversely correlated with renal function. Urinary sediment miR-221 and miR-222 levels correlate with lupus disease activity and may serve as biomarkers of LN.<\/jats:p>","DOI":"10.1177\/0961203312451334","type":"journal-article","created":{"date-parts":[[2012,6,8]],"date-time":"2012-06-08T23:31:23Z","timestamp":1339198283000},"page":"1190-1195","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":30,"title":["Urinary sediment ICAM-1 level in lupus nephritis"],"prefix":"10.1177","volume":"21","author":[{"given":"J","family":"Guan","sequence":"first","affiliation":[{"name":"Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong"},{"name":"Division of Nephrology, Renmin Hospital of Wuhan University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics, Prince of Wales Hospital, The 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