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We describe a 22-year-old Chinese female who presented with acute extensive gastrointestinal and genitourinary involvement who recovered following pulse intravenous methylprednisolone and cyclophosphamide. A high index of clinical suspicion is required to arrive at the diagnosis of SLE where only acute gastrointestinal and genitourinary manifestations are predominant, and other clinical, haematological and biochemical features of SLE are absent.<\/jats:p>","DOI":"10.1177\/0961203312455111","type":"journal-article","created":{"date-parts":[[2012,7,25]],"date-time":"2012-07-25T22:55:18Z","timestamp":1343256918000},"page":"1240-1243","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Acute onset of systemic lupus erythematosus with extensive gastrointestinal and genitourinary involvement"],"prefix":"10.1177","volume":"21","author":[{"given":"T-C","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GK-L","family":"Wansaicheong","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Tan Tock Seng Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BY-H","family":"Thong","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,7,25]]},"reference":[{"key":"bibr1-0961203312455111","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i24.2971"},{"key":"bibr2-0961203312455111","doi-asserted-by":"publisher","DOI":"10.1177\/0961203310374337"},{"key":"bibr3-0961203312455111","doi-asserted-by":"publisher","DOI":"10.1191\/0961203303lu433oa"},{"key":"bibr4-0961203312455111","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.50.4708"},{"key":"bibr5-0961203312455111","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2009.53"},{"key":"bibr6-0961203312455111","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-197604000-00040"},{"key":"bibr7-0961203312455111","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01551.x"},{"key":"bibr8-0961203312455111","doi-asserted-by":"publisher","DOI":"10.1191\/0961203304lu465cr"},{"key":"bibr9-0961203312455111","first-page":"2234","volume":"89","author":"Reissman P","year":"1994","journal-title":"Am J Gastroenterol"},{"key":"bibr10-0961203312455111","doi-asserted-by":"publisher","DOI":"10.1177\/0961203310386277"},{"key":"bibr11-0961203312455111","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.20.3.g00mc02779"},{"key":"bibr12-0961203312455111","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(88)80096-2"},{"key":"bibr13-0961203312455111","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/37.9.1023"},{"key":"bibr14-0961203312455111","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-4-150"},{"key":"bibr15-0961203312455111","doi-asserted-by":"publisher","DOI":"10.1177\/0961203311430219"},{"key":"bibr16-0961203312455111","first-page":"1018","volume":"29","author":"Ciccia F","year":"2011","journal-title":"Clin Exp Rheumatol"},{"key":"bibr17-0961203312455111","doi-asserted-by":"publisher","DOI":"10.1177\/0961203309345787"},{"key":"bibr18-0961203312455111","doi-asserted-by":"publisher","DOI":"10.1177\/0961203307081118"},{"key":"bibr19-0961203312455111","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-009-1364-z"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203312455111","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0961203312455111","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203312455111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:12:32Z","timestamp":1777677152000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0961203312455111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,25]]},"references-count":19,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.1177\/0961203312455111"],"URL":"https:\/\/doi.org\/10.1177\/0961203312455111","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,25]]}}}