{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:03:59Z","timestamp":1791353039043,"version":"4.3.1"},"reference-count":57,"publisher":"SAGE Publications","issue":"13","license":[{"start":{"date-parts":[[2012,8,14]],"date-time":"2012-08-14T00:00:00Z","timestamp":1344902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:p>T helper type 17 (Th17) cells, a novel distinct subset of Th cell, can secrete interleukin (IL)-17 in humans. Although recent data suggest that Th17 cells and IL-17 play an important role in the pathogenesis of lupus nephritis (LN), the expression of Th17-related cytokines in the kidneys of SLE patients has not been studied in detail. In the present study, we investigated circulating Th17-cell frequencies using flow cytometry and serum Th17-related cytokine levels by enzyme-linked immunosorbent assay (ELISA) in 24 LN patients (17 patients with class IV and seven patients with class V) and 12 healthy controls. We also investigated glomerular Th17-related cytokine expression in LN patients and minimal change nephropathy (MCN) patients using immunohistochemistry. Our results showed significantly higher median frequencies of circulating Th17 cells in LN patients (0.68%) than in healthy controls (0.12%, p\u2009&lt;\u20090.001). Serum levels of IL-17, IL-6 and IL-23 were significantly higher in LN patients (median 7.26, 232.60 and 37.01\u2009pg\/ml, respectively) than in healthy controls (median 0.82, 34.60 and 7.42\u2009pg\/ml, respectively; all p\u2009&lt;\u20090.001). Circulating Th17-cell frequencies were positively correlated with SLEDAI, renal SLEDAI and histological activity index, the degree of cellular crescent and endocapillary proliferation. Significantly higher levels of glomerular IL-17 and IL-23 expression were observed in renal biopsies from class IV LN patients as compared to those from MCN patients and normal controls. Glomerular IL-17 and IL-23 expression levels were positively correlated with renal SLEDAI and histological activity index for LN patients. Our results suggest the potential role of the IL-23\/Th17 axis in the intra-renal inflammation of SLE.<\/jats:p>","DOI":"10.1177\/0961203312457718","type":"journal-article","created":{"date-parts":[[2012,8,14]],"date-time":"2012-08-14T22:09:56Z","timestamp":1344982196000},"page":"1385-1396","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":125,"title":["The potential role of Th17 cells and Th17-related cytokines in the pathogenesis of lupus nephritis"],"prefix":"10.1177","volume":"21","author":[{"given":"D-Y","family":"Chen","sequence":"first","affiliation":[{"name":"Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital and Faculty of Medicine, National Yang Ming University, Taiwan"},{"name":"Institute of Microbiology and Immunology, Chung Shan Medical University, Taiwan"},{"name":"Institute of Biomedical Science, National Chung Hsing University, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y-M","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital and Faculty of Medicine, National Yang Ming University, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M-C","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Taichung Veterans General Hospital, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T-Y","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital and Faculty of Medicine, National Yang Ming University, Taiwan"},{"name":"Institute of Microbiology and Immunology, Chung Shan Medical University, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W-T","family":"Hung","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital and Faculty of Medicine, National Yang Ming University, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J-L","family":"Lan","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital and Faculty of Medicine, National Yang Ming University, Taiwan"},{"name":"Institute of Microbiology and Immunology, Chung Shan Medical University, Taiwan"},{"name":"Institute of Biomedical Science, National Chung Hsing University, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,8,14]]},"reference":[{"key":"bibr1-0961203312457718","first-page":"1","volume":"48","author":"Cameron JS","year":"1979","journal-title":"QJM"},{"key":"bibr2-0961203312457718","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(00)70262-9"},{"key":"bibr3-0961203312457718","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5001777"},{"key":"bibr4-0961203312457718","first-page":"1","volume":"18","author":"Lee YH","year":"2009","journal-title":"Lupus"},{"key":"bibr5-0961203312457718","doi-asserted-by":"publisher","DOI":"10.1191\/096120398678920730"},{"key":"bibr6-0961203312457718","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000108969.21691.5D"},{"key":"bibr7-0961203312457718","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(99)70082-X"},{"key":"bibr8-0961203312457718","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.00730.x"},{"key":"bibr9-0961203312457718","first-page":"57","volume":"19","author":"Kelley VR","year":"1999","journal-title":"Semin Nephrol"},{"key":"bibr10-0961203312457718","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199908)42:8<1644::AID-ANR12>3.0.CO;2-L"},{"key":"bibr11-0961203312457718","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200109)44:9<2097::AID-ART360>3.0.CO;2-6"},{"key":"bibr12-0961203312457718","doi-asserted-by":"publisher","DOI":"10.1038\/ni0407-345"},{"key":"bibr13-0961203312457718","doi-asserted-by":"publisher","DOI":"10.1038\/ni1254"},{"key":"bibr14-0961203312457718","doi-asserted-by":"publisher","DOI":"10.1038\/ni1261"},{"key":"bibr15-0961203312457718","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.4049\/jimmunol.160.7.3513","volume":"160","author":"Jovanovic DV","year":"1998","journal-title":"J Immunol"},{"key":"bibr16-0961203312457718","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.4049\/jimmunol.162.4.2347","volume":"162","author":"Laan M","year":"1999","journal-title":"J Immunol"},{"key":"bibr17-0961203312457718","first-page":"515","volume":"35","author":"Agarwal S","year":"2008","journal-title":"J Rheumatol"},{"key":"bibr18-0961203312457718","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2008.01.019"},{"key":"bibr19-0961203312457718","doi-asserted-by":"publisher","DOI":"10.1002\/art.24499"},{"key":"bibr20-0961203312457718","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e328304b6b5"},{"key":"bibr21-0961203312457718","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-009-9365-x"},{"key":"bibr22-0961203312457718","doi-asserted-by":"publisher","DOI":"10.1191\/096120300678828703"},{"key":"bibr23-0961203312457718","doi-asserted-by":"publisher","DOI":"10.3109\/s10165-007-0568-9"},{"key":"bibr24-0961203312457718","doi-asserted-by":"publisher","DOI":"10.1038\/ni1488"},{"key":"bibr25-0961203312457718","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keg255"},{"key":"bibr26-0961203312457718","doi-asserted-by":"publisher","DOI":"10.1002\/art.22866"},{"key":"bibr27-0961203312457718","doi-asserted-by":"publisher","DOI":"10.1186\/ar2682"},{"key":"bibr28-0961203312457718","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.12.8761"},{"key":"bibr29-0961203312457718","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2009.04031.x"},{"key":"bibr30-0961203312457718","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"bibr31-0961203312457718","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780350606"},{"key":"bibr32-0961203312457718","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.080341"},{"key":"bibr33-0961203312457718","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq284"},{"key":"bibr34-0961203312457718","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.34.982"},{"key":"bibr35-0961203312457718","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2004.02588.x"},{"key":"bibr36-0961203312457718","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2008.11.001"},{"key":"bibr37-0961203312457718","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-010-1771-0"},{"key":"bibr38-0961203312457718","doi-asserted-by":"publisher","DOI":"10.1186\/ar2964"},{"key":"bibr39-0961203312457718","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900385"},{"key":"bibr40-0961203312457718","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2007.10.007"},{"key":"bibr41-0961203312457718","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.11.7791"},{"key":"bibr42-0961203312457718","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2008.03.006"},{"key":"bibr43-0961203312457718","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903566"},{"key":"bibr44-0961203312457718","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.1.271"},{"key":"bibr45-0961203312457718","first-page":"543","volume":"116","author":"Dong G","year":"2003","journal-title":"Chin Med J"},{"key":"bibr46-0961203312457718","doi-asserted-by":"publisher","DOI":"10.1002\/art.27221"},{"key":"bibr47-0961203312457718","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M207577200"},{"key":"bibr48-0961203312457718","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20090585"},{"key":"bibr49-0961203312457718","doi-asserted-by":"publisher","DOI":"10.3109\/s10165-007-0568-9"},{"key":"bibr50-0961203312457718","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.12.7849"},{"key":"bibr51-0961203312457718","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep255"},{"key":"bibr52-0961203312457718","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009030337"},{"key":"bibr53-0961203312457718","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.102"},{"key":"bibr54-0961203312457718","doi-asserted-by":"publisher","DOI":"10.1177\/0961203310389100"},{"key":"bibr55-0961203312457718","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2006.09.008"},{"key":"bibr56-0961203312457718","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2010.02.011"},{"key":"bibr57-0961203312457718","first-page":"417","volume-title":"Immunologic renal diseases","author":"Floege J","year":"1997"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203312457718","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0961203312457718","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203312457718","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:12:34Z","timestamp":1777677154000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0961203312457718"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,14]]},"references-count":57,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1177\/0961203312457718"],"URL":"https:\/\/doi.org\/10.1177\/0961203312457718","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,14]]}}}