{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:00:36Z","timestamp":1777928436539,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:p>\n                    Systemic lupus erythematosus (SLE) is an autoimmune disease of uncertain etiology that affects multiple tissues and organs. Arsenic trioxide (ATO) has been used in lupus-prone mice with a regulatory effect on immune abnormality. Tetra-arsenic tetra-sulfide (As\n                    <jats:sub>4<\/jats:sub>\n                    S\n                    <jats:sub>4<\/jats:sub>\n                    ), a traditional Chinese medicine, is effective on acute promyelocytic leukemia with mild side effects than ATO. In this study, a pilot study was performed to investigate the effects and the mechanism of As\n                    <jats:sub>4<\/jats:sub>\n                    S\n                    <jats:sub>4<\/jats:sub>\n                    on the lupus-prone BXSB mice. Improvement of monocytosis ( p\u2009&lt;\u20090.05) in spleen and decreased serum interleukin-6 (IL-6) ( p\u2009=\u20090.0277) were observed with As\n                    <jats:sub>4<\/jats:sub>\n                    S\n                    <jats:sub>4<\/jats:sub>\n                    treatment. As\n                    <jats:sub>4<\/jats:sub>\n                    S\n                    <jats:sub>4<\/jats:sub>\n                    -treated mice exhibited amelioration of skin, liver and renal disease with mild side effects. Histological analysis revealed that As\n                    <jats:sub>4<\/jats:sub>\n                    S\n                    <jats:sub>4<\/jats:sub>\n                    suppressed immune complex deposition, mesangial proliferation and inflammatory cell infiltration in kidney and liver. Our study support that As\n                    <jats:sub>4<\/jats:sub>\n                    S\n                    <jats:sub>4<\/jats:sub>\n                    selectively suppresses cutaneous lupus and nephritis in BXSB mice and might be a potential treatment for SLE.\n                  <\/jats:p>","DOI":"10.1177\/0961203313478302","type":"journal-article","created":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T05:14:24Z","timestamp":1364966064000},"page":"469-476","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Effects of tetra-arsenic tetra-sulfide on BXSB lupus-prone mice: a pilot study"],"prefix":"10.1177","volume":"22","author":[{"given":"Y","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Dermatology, Peking University People's Hospital, 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