{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:34:39Z","timestamp":1791318879105,"version":"4.3.1"},"reference-count":19,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:p>Anti-tumor necrosis factor-alpha (TNF-\u03b1) immunotherapy is currently used in the treatment of various inflammatory diseases such as rheumatoid arthritis, psoriasis, psoriatic arthritis, ankylosing spondylitis and Crohn\u2019s disease. Infliximab is a chimeric monoclonal antibody that binds to transmembrane-bound and soluble TNF-\u03b1. Previously, a discoid lupus erythematosus-like eruption linked to its use was rarely reported in patients with rheumatoid arthritis. We present a case of rheumatoid arthritis which developed such an eruption after treatment with infliximab. The lesions resolved after the discontinuation of infliximab. In the present case, the clinical, serological and immunohistochemical features of our patient are discussed with the literature.<\/jats:p>","DOI":"10.1177\/0961203313479423","type":"journal-article","created":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T05:14:24Z","timestamp":1364966064000},"page":"515-518","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Infliximab-induced discoid lupus erythematosus"],"prefix":"10.1177","volume":"22","author":[{"given":"BC","family":"Cemil","sequence":"first","affiliation":[{"name":"Department of Dermatology, Ministry of Health Diskapi Yildirim Beyazit Education and Research Hospital, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Atas","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Ministry of Health Diskapi Yildirim Beyazit Education and Research Hospital, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Canpolat","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Ministry of Health Diskapi Yildirim Beyazit Education and Research Hospital, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Akca","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ministry of Health Diskapi Yildirim Beyazit Education and Research Hospital, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Sasmaz","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Ministry of Health Diskapi Yildirim Beyazit Education and Research Hospital, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,4,3]]},"reference":[{"key":"bibr1-0961203313479423","doi-asserted-by":"crossref","unstructured":"Moustou AE, Matekovits A, Dessinioti C,\n                      et al\n                      . Cutaneous side effects of anti-tumor necrosis factor biologic therapy: A clinical review.\n                      J Am Acad Dermatol\n                      2009; 61: 486\u2013504.","DOI":"10.1016\/j.jaad.2008.10.060"},{"key":"bibr2-0961203313479423","doi-asserted-by":"crossref","unstructured":"Exarchou SA, Voulgari PV, Markatseli TE,\n                      et al\n                      . Immunemediated skin lesions in patients treated with anti-tumour necrosis factor alpha inhibitors.\n                      Scand J Rheumatol\n                      2009; 38: 328\u2013331.","DOI":"10.1080\/03009740902922612"},{"key":"bibr3-0961203313479423","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-002-0654-5"},{"key":"bibr4-0961203313479423","doi-asserted-by":"crossref","unstructured":"Takahashi H, Kaneta K, Honma M,\n                      et al\n                      . Sarcoidosis during infliximab therapy for Crohn\u2019s disease.\n                      J Dermatol\n                      2010; 37: 471\u2013474.","DOI":"10.1111\/j.1346-8138.2010.00861.x"},{"key":"bibr5-0961203313479423","doi-asserted-by":"crossref","unstructured":"Spillane AP, Xia Y, Sniezek PJ. Drug-induced lupus erythematosus in a patient treated with adalumimab.\n                      J Am Acad Dermatol\n                      2007; 56: 114\u2013116.","DOI":"10.1016\/j.jaad.2007.01.040"},{"key":"bibr6-0961203313479423","doi-asserted-by":"publisher","DOI":"10.1191\/0961203302lu236cr"},{"key":"bibr7-0961203313479423","doi-asserted-by":"crossref","unstructured":"Gupta AK, Skinner AR. A review of the use of infliximab to manage cutaneous dermatoses.\n                      J Cutan Med Surg\n                      2004; 8: 77\u201389.","DOI":"10.1177\/120347540400800202"},{"key":"bibr8-0961203313479423","doi-asserted-by":"crossref","unstructured":"Stratigos AJ, Antoniou C, Stamathioudaki S,\n                      et al\n                      . Discoid lupus erythematosus-like eruption induced by infliximab.\n                      Clin Exp Dermatol\n                      2004; 29: 150\u2013153.","DOI":"10.1111\/j.1365-2230.2004.01471.x"},{"key":"bibr9-0961203313479423","doi-asserted-by":"crossref","unstructured":"Wetter DA, Davis MD. Lupus-like syndrome attributable to antitumor necrosis factor alpha therapy in 14 patients during an 8-year period at Mayo Clinic.\n                      Mayo Clin Proc\n                      2009; 84: 979\u2013984.","DOI":"10.4065\/84.11.979"},{"key":"bibr10-0961203313479423","doi-asserted-by":"crossref","unstructured":"Aringer M, Smolen JS. The role of tumor necrosis factor-alpha in systemic lupus erythematosus.\n                      Arthritis Res Ther\n                      2008; 10: 202\u2013210.","DOI":"10.1186\/ar2341"},{"key":"bibr11-0961203313479423","doi-asserted-by":"crossref","unstructured":"Pallotta P, Cianchini G, Ruffelli M,\n                      et al\n                      . Infliximab-induced lupus-like reaction in a patient with psoriatic arthritis.\n                      Rheumatology (Oxford)\n                      2006; 45: 116\u2013117.","DOI":"10.1093\/rheumatology\/kei227"},{"key":"bibr12-0961203313479423","doi-asserted-by":"crossref","unstructured":"Shakoor N, Michalska M, Harris CA,\n                      et al\n                      . Drug-induced systemic lupus erythematosus associated with etanercept therapy.\n                      Lancet\n                      2002; 359: 579\u2013580.","DOI":"10.1016\/S0140-6736(02)07714-0"},{"key":"bibr13-0961203313479423","doi-asserted-by":"crossref","unstructured":"Brion PH, Mittal-Henkle A, Kalunian KC. Autoimmune skin rashes associated with etanercept for rheumatoid arthritis.\n                      Ann Intern Med\n                      1999; 131: 634.","DOI":"10.7326\/0003-4819-131-8-199910190-00031"},{"key":"bibr14-0961203313479423","doi-asserted-by":"crossref","unstructured":"Misery L, Perrot JL, Gentil-Perret A,\n                      et al\n                      . Dermatological complications of etanercept therapy for rheumatoid arthritis.\n                      Br J Dermatol\n                      2002; 146: 334\u2013335.","DOI":"10.1046\/j.1365-2133.2002.4653_4.x"},{"key":"bibr15-0961203313479423","unstructured":"Gonnet-Gracia C, Barnetche T, Richez C,\n                      et al\n                      . Anti-nuclear antibodies, anti-DNA and C4 complement evolution in rheumatoid arthritis and ankylosing spondylitis treated with TNF-alpha blockers.\n                      Clin Exp Rheumatol\n                      2008; 26: 401\u2013407."},{"key":"bibr16-0961203313479423","doi-asserted-by":"crossref","unstructured":"Lorenz HM, Herrmann M, Winkler T,\n                      et al\n                      . Role of apoptosis in autoimmunity.\n                      Apoptosis\n                      2000; 5: 443\u2013449.","DOI":"10.1023\/A:1009692902805"},{"key":"bibr17-0961203313479423","doi-asserted-by":"crossref","unstructured":"Eriksson C, Engstrand S, Sundqvist KG,\n                      et al\n                      . Autoantibody formation in patients with rheumatoid arthritis treated with anti-TNF alpha.\n                      Ann Rheum Dis\n                      2005; 64: 403\u2013407.","DOI":"10.1136\/ard.2004.024182"},{"key":"bibr18-0961203313479423","doi-asserted-by":"crossref","unstructured":"Zheng L, Fisher G, Miller RE,\n                      et al\n                      . Induction of apoptosis in mature T cells by tumour necrosis factor.\n                      Nature\n                      1995; 377: 348\u2013351.","DOI":"10.1038\/377348a0"},{"key":"bibr19-0961203313479423","doi-asserted-by":"crossref","unstructured":"Williams EL, Gadola S, Edwards CJ. Anti-TNF-induced lupus.\n                      Rheumatology (Oxford)\n                      2009; 48: 716\u2013720.","DOI":"10.1093\/rheumatology\/kep080"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203313479423","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0961203313479423","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203313479423","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:13:06Z","timestamp":1777677186000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0961203313479423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1177\/0961203313479423"],"URL":"https:\/\/doi.org\/10.1177\/0961203313479423","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4]]}}}