{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:00:50Z","timestamp":1777928450296,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2013,7,26]],"date-time":"2013-07-26T00:00:00Z","timestamp":1374796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:p>Cutaneous manifestations occur frequently in systemic lupus erythematosus (SLE) and are pathognomonic in subacute-cutaneous lupus erythematosus (SCLE) and chronic cutaneous lupus erythematosus (CCLE). Although B-cell depletion therapy (BCDT) has demonstrated efficacy in SLE with visceral involvement, its usefulness for patients with predominant skin manifestations has not been fully established. In this single-centre, retrospective study 14 consecutive SLE, one CCLE and two SCLE patients with recalcitrant skin involvement were treated with 2\u2009\u00d7\u2009rituximab 1\u2009g, and 1\u2009\u00d7\u2009cyclophosphamide 750\u2009mg.<\/jats:p>\n                  <jats:p>Six months after BCDT, nine of 17 (53%) patients were in complete (CR) or partial remission (PR). Relapses occurred in 12 patients (71%) at a mean time of 10\u2009\u00b1\u20091.8 months after BCDT. A second cycle of BCDT achieved a more sustained remission in seven of nine patients (78%) lasting for a mean time of 18.4\u2009\u00b1\u20092.7 months. Minor adverse events were experienced by three patients. Mean follow-up was 30 months.<\/jats:p>\n                  <jats:p>Our own results and the literature review demonstrate that BCDT based on rituximab is well tolerated and may be effective for cutaneous lesions of lupus erythematosus. Randomized controlled trials are necessary to further evaluate the value of BCDT for this group of patients.<\/jats:p>","DOI":"10.1177\/0961203313497115","type":"journal-article","created":{"date-parts":[[2013,7,26]],"date-time":"2013-07-26T14:16:18Z","timestamp":1374848178000},"page":"932-939","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":53,"title":["Effects of rituximab-based B-cell depletion therapy on skin manifestations of lupus erythematosus \u2013 report of 17 cases and review of the literature"],"prefix":"10.1177","volume":"22","author":[{"given":"SC","family":"Hofmann","sequence":"first","affiliation":[{"name":"Centre for Rheumatology Research, University College London, UK"},{"name":"Department of Dermatology and Allergy, University Witten\/Herdecke, Helios Hospital Wuppertal, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MJ","family":"Leandro","sequence":"additional","affiliation":[{"name":"Centre for Rheumatology Research, University College London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SD","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University College London Hospital, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DA","family":"Isenberg","sequence":"additional","affiliation":[{"name":"Centre for Rheumatology Research, University College London, 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