{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:00:52Z","timestamp":1777928452054,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2013,7,26]],"date-time":"2013-07-26T00:00:00Z","timestamp":1374796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:p>Poor specific antibody response is a well-known primary immunodeficiency that is related to hypogammaglobulinemia or common variable immunodeficiency (CVID). The co-existence of CVID or hypogammaglobulinemia and systemic lupus erythematosus (SLE) has been rarely described. In all reported cases, the diagnosis of SLE antedates CVID.<\/jats:p>\n                  <jats:p>We report a 15-year-old Saudi girl who was diagnosed with poor specific antibody response at age 6 years in the form of poor or no antibody response and dysgammaglobulinemia. She developed SLE with musculoskeletal and hematological manifestations, positive antinuclear antibody and high anti-dsDNA nine years later. She was treated with rituximab with good response.<\/jats:p>","DOI":"10.1177\/0961203313497820","type":"journal-article","created":{"date-parts":[[2013,7,26]],"date-time":"2013-07-26T14:16:18Z","timestamp":1374848178000},"page":"961-966","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Poor specific antibody response immunodeficiency (dysgammaglobulinemia) predates systemic lupus erythematosus"],"prefix":"10.1177","volume":"22","author":[{"given":"H Al","family":"Hamzi","sequence":"first","affiliation":[{"name":"Department of Medicine, King Faisal Specialist Hospital and Research Centre, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A Al","family":"Shaikh","sequence":"additional","affiliation":[{"name":"Department of Medicine, King Faisal Specialist Hospital and Research Centre, Saudi 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