{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:01:16Z","timestamp":1777928476938,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2013,12,19]],"date-time":"2013-12-19T00:00:00Z","timestamp":1387411200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:p>The case presented describes a high-risk pregnancy of a woman with systemic lupus erythematosus (SLE) with multiple lesions of central nervous system (CNS), vasculitis, secondary epilepsy and antiphospholipid syndrome (APS). At gestational age 28 weeks and 3 days the pregnancy was urgently terminated via caesarean section and an extremely hypotrophic immature newborn with a birth weight of 580\u2009g was born. The high disease activity in the mother at the time of conception and the histologically proven chronic placental insufficiency due to APS are presumably the causes for the extensive hypotrophy of the neonate. The significant comorbidity of the newborn, including respiratory distress syndrome, bronchopulmonary dysplasia, necrotizing enterocolitis, osteopathy of prematurity, transient hypothyroidism and hypocortisolism, vesicoureteral reflux, and hypertonic-hyperexcitation syndrome complicated his three-month stay in NICU. A positive titre of transplacentally transferred anticardiolipin and anti-\u03b22 glycoprotein antibody was detected in the child and persisted through the following 30 months. During the three-year follow-up, significantly delayed neuropsychological development with microcephaly (\u22124 SD) and short stature of the child was observed. Finally, the authors discuss possible causes of neuropsychological consequences in children of mothers with SLE and APS and emphasize the need for long-term monitoring and specialized care to improve development of these children.<\/jats:p>","DOI":"10.1177\/0961203313517406","type":"journal-article","created":{"date-parts":[[2013,12,20]],"date-time":"2013-12-20T00:21:23Z","timestamp":1387498883000},"page":"313-318","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Extremely hypotrophic newborn of mother with systemic lupus erythematosus and antiphospholipid syndrome"],"prefix":"10.1177","volume":"23","author":[{"given":"A","family":"Mockova","sequence":"first","affiliation":[{"name":"Department of Neonatology, Faculty of Medicine in Pilsen and University Hospital, Charles University in Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Dortova","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Faculty of Medicine in Pilsen and University Hospital, Charles University in Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Dort","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Faculty of Medicine in Pilsen and University Hospital, Charles University in Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Nahlovsky","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Faculty of Medicine in Pilsen and University Hospital, Charles University in Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Korecko","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine in Pilsen and University Hospital, University in Pilsen, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z","family":"Ulcova-Gallova","sequence":"additional","affiliation":[{"name":"Department of Reproductive Immunology, Genetic Pilsen Inc., Pilsen, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,12,19]]},"reference":[{"key":"bibr1-0961203313517406","doi-asserted-by":"publisher","DOI":"10.1191\/0961203306lu2274rr"},{"key":"bibr2-0961203313517406","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2011.11.010"},{"key":"bibr3-0961203313517406","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq376"},{"key":"bibr4-0961203313517406","volume-title":"Bayley Scales of Infant Development","author":"Bayley N","year":"1993","edition":"2"},{"key":"bibr5-0961203313517406","doi-asserted-by":"publisher","DOI":"10.1586\/eci.12.36"},{"key":"bibr6-0961203313517406","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-001-0776-z"},{"key":"bibr7-0961203313517406","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(84)80435-7"},{"key":"bibr8-0961203313517406","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(74)80109-5"},{"key":"bibr9-0961203313517406","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21888"},{"key":"bibr10-0961203313517406","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)81115-2"},{"key":"bibr11-0961203313517406","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.01753.x"},{"key":"bibr12-0961203313517406","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200306000-00031"},{"key":"bibr13-0961203313517406","doi-asserted-by":"publisher","DOI":"10.3109\/14767050903414492"},{"key":"bibr14-0961203313517406","doi-asserted-by":"publisher","DOI":"10.1177\/0961203306072382"},{"key":"bibr15-0961203313517406","doi-asserted-by":"publisher","DOI":"10.1177\/0961203306071005"},{"key":"bibr16-0961203313517406","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-201167"},{"key":"bibr17-0961203313517406","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.137281"},{"key":"bibr18-0961203313517406","doi-asserted-by":"publisher","DOI":"10.1177\/0961203308089326"},{"key":"bibr19-0961203313517406","doi-asserted-by":"publisher","DOI":"10.1002\/art.23311"},{"key":"bibr20-0961203313517406","doi-asserted-by":"publisher","DOI":"10.1080\/17402520500217844"},{"key":"bibr21-0961203313517406","doi-asserted-by":"publisher","DOI":"10.1191\/0961203304lu2018oa"},{"key":"bibr22-0961203313517406","doi-asserted-by":"publisher","DOI":"10.1177\/0961203309354542"},{"key":"bibr23-0961203313517406","doi-asserted-by":"crossref","unstructured":"Abisror N, Mekinian A, Lachassinne E, et\u00a0al. Autism spectrum disorders in babies born to mothers with antiphospholipid syndrome.\n                      Semin Arthritis Rheum.\n                      Epub ahead of print 30 July 2013. 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