{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:04:23Z","timestamp":1792008263770,"version":"4.4.0"},"reference-count":33,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T00:00:00Z","timestamp":1395705600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of this paper is to evaluate ovarian reserve in primary antiphospholipid syndrome (PAPS) women and the association between ovarian reserve tests and clinical and laboratorial parameters, and anti-corpus luteum antibody (anti-CoL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We screened 85 female patients between 18 to 40 years old with APS. Of these, 67 patients were excluded because of association with other autoimmune diseases ( n\u2009=\u200942), contraindication or unwillingness to stop hormonal contraceptive ( n\u2009=\u200921), current pregnancy or breastfeeding ( n\u2009=\u20093) and previous ovarian surgery ( n\u2009=\u20091). Therefore, a cross-sectional study was conducted in 18 PAPS patients and 24 healthy women. They were evaluated at early follicular phase with measurement of follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol, and anti-M\u00fcllerian hormone (AMH) and sonographic antral follicle count (AFC). Serum measurement of anti-CoL was determined by immunoblot analysis. All analyses were performed after at least six months from the last intake of hormonal contraceptive and resumption of menstruation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean age was comparable in PAPS and controls (33.0\u2009\u00b1\u20095.0 vs. 30.4\u2009\u00b1\u20097.0 years; p\u2009=\u20090.19). Regarding ovarian reserve tests, the frequencies of low AFC (\u226410) (56% vs. 22%, p\u2009=\u20090.04) and very low AFC (\u22645) (37% vs. 9%, p\u2009=\u20090.04) were significantly higher in PAPS patients than controls. Trends of higher frequencies of reduced (&lt;1.0\u2009ng\/ml), low (&lt;0.5\u2009ng\/ml) and negligible (&lt;0.2\u2009ng\/ml) AMH levels were found in PAPS patients ( p\u2009=\u20090.08, p\u2009=\u20090.07 and p\u2009=\u20090.07, respectively). FSH, LH and estradiol were similar in patients and controls. There was no association between low ovarian reserve and specific types of antiphospholipid antibodies. Anti-CoL was solely observed in PAPS patients (11% vs. 0%; p\u2009=\u20090.177) and was not related to ovarian reserve tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Women suffering from PAPS possessed reduced ovarian reserve, with prevalence greater than 50%.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0961203314529468","type":"journal-article","created":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T22:49:08Z","timestamp":1395787748000},"page":"862-867","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":39,"title":["Ovarian reserve in women with primary antiphospholipid syndrome"],"prefix":"10.1177","volume":"23","author":[{"given":"LYS","family":"Yamakami","sequence":"first","affiliation":[{"name":"Department of Gynecology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PC","family":"Serafini","sequence":"additional","affiliation":[{"name":"Department of Gynecology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DB","family":"de Araujo","sequence":"additional","affiliation":[{"name":"Division of Rheumatology"},{"name":"Department of Rheumatology, Hospital do Servidor P\u00fablico Estadual de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Bonf\u00e1","sequence":"additional","affiliation":[{"name":"Division of Rheumatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EP","family":"Leon","sequence":"additional","affiliation":[{"name":"Division of Rheumatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EC","family":"Baracat","sequence":"additional","affiliation":[{"name":"Department of Gynecology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CA","family":"Silva","sequence":"additional","affiliation":[{"name":"Division of Rheumatology"},{"name":"Pediatric Rheumatology Unit, Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,3,25]]},"reference":[{"key":"bibr1-0961203314529468","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199907)42:7<1309::AID-ANR1>3.0.CO;2-F"},{"key":"bibr2-0961203314529468","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e3282a4a65f"},{"key":"bibr3-0961203314529468","doi-asserted-by":"publisher","DOI":"10.1210\/er.2009-0006"},{"key":"bibr4-0961203314529468","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.09.036"},{"key":"bibr5-0961203314529468","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.04.060"},{"key":"bibr6-0961203314529468","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0b013e32833b6c70"},{"key":"bibr7-0961203314529468","doi-asserted-by":"publisher","DOI":"10.3109\/13697137.2011.642426"},{"key":"bibr8-0961203314529468","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem105"},{"key":"bibr9-0961203314529468","doi-asserted-by":"publisher","DOI":"10.1177\/0961203310383300"},{"key":"bibr10-0961203314529468","unstructured":"Almeida PM. 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