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However, autoimmune disorders and siliconomas with granulomatous reactions after silicone implant rupture have been described. We report cases of four women who developed systemic disorders following rupture of silicone breast implants resulting in lymph node and thoracic silicone infiltration. The symptoms in these cases, including arthralgia, myalgia, generalized weakness, severe fatigue, sleeping disturbances, cognitive impairment, memory loss, irritable bowel syndrome, and weight loss, clearly match the criteria of the recently defined autoimmune\/inflammatory syndrome induced by adjuvants (ASIA).<\/jats:p>","DOI":"10.1177\/0961203314562622","type":"journal-article","created":{"date-parts":[[2015,3,23]],"date-time":"2015-03-23T07:20:52Z","timestamp":1427095252000},"page":"463-468","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":39,"title":["Severe ASIA syndrome associated with lymph node, thoracic, and pulmonary silicone infiltration following breast implant rupture: experience with four cases"],"prefix":"10.1177","volume":"24","author":[{"given":"G","family":"Nesher","sequence":"first","affiliation":[{"name":"Department of Internal Medicine A, Shaare Zedek Medical Center and the Hebrew University Medical School, Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Soriano","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Rheumatology, Campus Bio-Medico University, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Shlomai","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Sheba Medical Center, Tel Hashomer, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Iadgarov","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hasharon Hospital \u2013 Rabin Medical Center, Israel"},{"name":"Sackler School of Medicine, Tel Aviv University, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T R","family":"Shulimzon","sequence":"additional","affiliation":[{"name":"The Pulmonary Institute, Sheba Medical Center, Tel Hashomer, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Borella","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology, University of Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Dicker","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hasharon Hospital \u2013 Rabin Medical Center, Israel"},{"name":"Sackler School of Medicine, Tel Aviv University, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Shoenfeld","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine, Tel Aviv University, Israel"},{"name":"The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,3,23]]},"reference":[{"key":"bibr1-0961203314562622","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199811000-00017"},{"key":"bibr2-0961203314562622","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4741.2009.00765.x"},{"key":"bibr3-0961203314562622","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2008.03196.x"},{"key":"bibr4-0961203314562622","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199205000-00029"},{"key":"bibr5-0961203314562622","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.4.537"},{"key":"bibr6-0961203314562622","doi-asserted-by":"publisher","DOI":"10.1177\/0961203309347795"},{"key":"bibr7-0961203314562622","first-page":"196","volume":"31","author":"Asherson RA","year":"2004","journal-title":"J Rheumatol"},{"key":"bibr8-0961203314562622","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-007-0659-1"},{"key":"bibr9-0961203314562622","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2010.07.006"},{"key":"bibr10-0961203314562622","first-page":"121","volume":"9","author":"Blum A","year":"2007","journal-title":"Isr Med Assoc J"},{"key":"bibr11-0961203314562622","first-page":"1003","volume":"12","author":"Vaamonde R","year":"1997","journal-title":"Histol Histopathol"},{"key":"bibr12-0961203314562622","first-page":"616","volume":"275","author":"Hennekens CH","year":"1996","journal-title":"A retrospective cohort study. 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