{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T22:58:49Z","timestamp":1784674729128,"version":"3.55.0"},"reference-count":37,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2015,1,20]],"date-time":"2015-01-20T00:00:00Z","timestamp":1421712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The objective of this paper is to describe renal outcomes in a group of Egyptian patients with lupus nephritis and to identify variable prognostic factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>The records of 135 patients (129 females, six males) with biopsy-proven lupus nephritis seen between 1999 and 2011 at Kasr Al-Aini Hospital, Cairo University, were reviewed and included in a retrospective analysis. Biopsies were classified according to the WHO classification. Renal outcomes were defined according to the Renal Subcommittee of Renal Insufficiency of the American College of Rheumatology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean follow-up period was 55.64\u2009\u00b1\u200925.68 (range 4\u2013156) months. Thirty-nine patients (29.9%) developed an adverse final outcome. This composite outcome, defined as persistent elevation of serum creatinine\u2009\u2265\u20091.2\u2009mg\/dl, chronic renal insufficiency, end-stage renal disease or death, was seen in 12 (8.9%), seven (5.2%), three (2.2%) and 17 (12.6%) patients, respectively. The overall patient survival was 93.5% and 87.5% at five and 10 years, respectively. Factors associated with an adverse outcome included male gender ( p\u2009=\u20090.037), hypertension at nephritis onset ( p\u2009=\u20090.001), serum creatinine \u22651.2\u2009mg\/dl ( p\u2009&lt;\u20090.001), urinary casts ( p\u2009=\u20090.006), anticardiolipin antibodies ( p\u2009=\u20090.03), class IV nephritis ( p\u2009&lt;\u20090.001), hyaline thrombosis (0.003), glomerular sclerosis ( p\u2009=\u20090.002), tubular atrophy( p\u2009&lt;\u20090.001), interstitial fibrosis ( p\u2009&lt;\u20090.001) and a higher chronicity index ( p\u2009=\u20090.006). Time-dependent factors associated with an adverse outcome included failure to achieve remission within the first year, uncontrolled hypertension, persistently low C3 and development of flares ( p\u2009=\u20090.003,\u2009&lt;\u20090.001, = 0.004, = 0.003, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The association of several adverse prognostic factors with the development of poor renal outcome has been confirmed in this study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0961203314567751","type":"journal-article","created":{"date-parts":[[2015,1,21]],"date-time":"2015-01-21T21:47:26Z","timestamp":1421876846000},"page":"331-338","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":32,"title":["Renal outcomes among Egyptian lupus nephritis patients: a retrospective analysis of 135 cases from a single centre"],"prefix":"10.1177","volume":"24","author":[{"given":"G A","family":"Mahmoud","sequence":"first","affiliation":[{"name":"Rheumatology and Rehabilitation Department, Faculty of Medicine, Cairo University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H S","family":"Zayed","sequence":"additional","affiliation":[{"name":"Rheumatology and Rehabilitation Department, Faculty of Medicine, Cairo University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S A","family":"Ghoniem","sequence":"additional","affiliation":[{"name":"Rheumatology and Rehabilitation Department, Faculty of Medicine, Cairo University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,1,20]]},"reference":[{"key":"bibr1-0961203314567751","doi-asserted-by":"publisher","DOI":"10.1177\/0961203310376522"},{"key":"bibr2-0961203314567751","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e31827f4ee3"},{"key":"bibr3-0961203314567751","doi-asserted-by":"publisher","DOI":"10.1191\/0961203305lu2057oa"},{"key":"bibr4-0961203314567751","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1994.70"},{"key":"bibr5-0961203314567751","doi-asserted-by":"publisher","DOI":"10.1191\/096120399678847605"},{"key":"bibr6-0961203314567751","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000243"},{"key":"bibr7-0961203314567751","doi-asserted-by":"publisher","DOI":"10.1177\/096120339500400206"},{"key":"bibr8-0961203314567751","first-page":"251","volume":"68","author":"Franco C","year":"2010","journal-title":"Bull NYU Hosp Jt Dis"},{"key":"bibr9-0961203314567751","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1996.528"},{"key":"bibr10-0961203314567751","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V13142"},{"key":"bibr11-0961203314567751","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfl159"},{"key":"bibr12-0961203314567751","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm245"},{"key":"bibr13-0961203314567751","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2010.01290.x"},{"key":"bibr14-0961203314567751","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"bibr15-0961203314567751","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780390303"},{"key":"bibr16-0961203314567751","unstructured":"Churg J, Bernstein J, Glassock RJ. Renal disease: Classification and atlas of glomerular disease, Tokyo: Igaku-Shoin, 1995, pp. 151\u2013179."},{"key":"bibr17-0961203314567751","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000091181.93122.55"},{"key":"bibr18-0961203314567751","doi-asserted-by":"publisher","DOI":"10.1177\/0961203309106831"},{"key":"bibr19-0961203314567751","doi-asserted-by":"publisher","DOI":"10.1191\/096120399678847605"},{"key":"bibr20-0961203314567751","doi-asserted-by":"publisher","DOI":"10.2147\/IJNRD.S34299"},{"key":"bibr21-0961203314567751","doi-asserted-by":"publisher","DOI":"10.1177\/0961203311415560"},{"key":"bibr22-0961203314567751","doi-asserted-by":"publisher","DOI":"10.1191\/0961203303lu340oa"},{"key":"bibr23-0961203314567751","first-page":"31","volume":"31","author":"Moon SJ","year":"2013","journal-title":"Clin Exp Rheumatol"},{"key":"bibr24-0961203314567751","doi-asserted-by":"publisher","DOI":"10.1177\/0961203310392422"},{"key":"bibr25-0961203314567751","doi-asserted-by":"publisher","DOI":"10.1177\/0961203311404912"},{"key":"bibr26-0961203314567751","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/604892"},{"key":"bibr27-0961203314567751","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.revmed.2004.09.003","volume":"26","author":"B\u00e9ji S","year":"2005","journal-title":"Rev Med Interne"},{"key":"bibr28-0961203314567751","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(00)70262-9"},{"key":"bibr29-0961203314567751","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2003.09.011"},{"key":"bibr30-0961203314567751","first-page":"727","volume":"22","author":"Kammoun K","year":"2011","journal-title":"Saudi J Kidney Dis Transpl"},{"key":"bibr31-0961203314567751","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20441"},{"key":"bibr32-0961203314567751","doi-asserted-by":"publisher","DOI":"10.1002\/art.20433"},{"key":"bibr33-0961203314567751","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken019"},{"key":"bibr34-0961203314567751","doi-asserted-by":"publisher","DOI":"10.1002\/art.20666"},{"key":"bibr35-0961203314567751","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00490109"},{"key":"bibr36-0961203314567751","doi-asserted-by":"publisher","DOI":"10.5858\/133.2.233"},{"key":"bibr37-0961203314567751","doi-asserted-by":"publisher","DOI":"10.1191\/096120398678920749"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203314567751","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0961203314567751","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203314567751","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:15:33Z","timestamp":1777677333000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0961203314567751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,20]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1177\/0961203314567751"],"URL":"https:\/\/doi.org\/10.1177\/0961203314567751","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,20]]}}}