{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:02:33Z","timestamp":1777928553454,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"13","license":[{"start":{"date-parts":[[2015,6,5]],"date-time":"2015-06-05T00:00:00Z","timestamp":1433462400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:p>Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder that affects a variety of organ systems. Anti-dsDNA Abs and complement factors have been used as indicators of lupus activity for more than 50 years. A novel indicator of activation in SLE is reported in this paper. Anti-collagen type II (CII) Ab was obviously elevated in patients with SLE compared to those patients with ankylosing spondylitis (AS) and healthy controls (HCs). Anti-CII-Ab-positive patients with SLE showed significantly higher levels of serum IgG and higher titers of ANA but lower levels of C3 and C4 than controls. A positive correlation was demonstrated between anti-CII Ab and serum IgG in SLE patients ( r\u2009=\u20090.50, p\u2009&lt;\u20090.0001). The negative correlations of anti-CII Ab with C3 and C4 were observed in SLE patients ( r\u2009=\u2009\u20130.36, p\u2009=\u20090.0013; r\u2009=\u2009\u20130.37, p\u2009=\u20090.0006, respectively). The reduced anti-CII Ab level was accompanied by decreased level of serum IgG and increased levels of C3 and C4 after regular treatment. Therefore, anti-CII Ab could be a novel indicator for monitoring activity of SLE.<\/jats:p>","DOI":"10.1177\/0961203315588970","type":"journal-article","created":{"date-parts":[[2015,6,5]],"date-time":"2015-06-05T21:55:32Z","timestamp":1433541332000},"page":"1370-1376","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Anti-CII antibody as a novel indicator to assess disease activity in systemic lupus erythematosus"],"prefix":"10.1177","volume":"24","author":[{"given":"C","family":"He","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, 302 Hospital of PLA, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,6,5]]},"reference":[{"key":"bibr1-0961203315588970","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071297"},{"key":"bibr2-0961203315588970","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.117200"},{"key":"bibr3-0961203315588970","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199805073381906"},{"key":"bibr4-0961203315588970","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.32.8.826"},{"key":"bibr5-0961203315588970","doi-asserted-by":"publisher","DOI":"10.1016\/S0174-173X(82)80009-5"},{"key":"bibr6-0961203315588970","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780331006"},{"key":"bibr7-0961203315588970","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780391015"},{"key":"bibr8-0961203315588970","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199910)42:10<2085::AID-ANR8>3.0.CO;2-Z"},{"key":"bibr9-0961203315588970","doi-asserted-by":"publisher","DOI":"10.1186\/ar3825"},{"key":"bibr10-0961203315588970","first-page":"575","volume":"27","author":"Kim WU","year":"2000","journal-title":"J Rheumatol"},{"key":"bibr11-0961203315588970","unstructured":"Wallace DJ. 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