{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:02:43Z","timestamp":1777928563299,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2015,9,7]],"date-time":"2015-09-07T00:00:00Z","timestamp":1441584000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Technetium-99m (Tc-99m) thyroid scintigraphy is a well known diagnostic tool that shows the entire gland in a single image. We aimed to evaluate its additive diagnostic value in subclinical autoimmune thyroid disease (S-AITD) in systemic lupus erythematosus (SLE) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We investigated 100 systemic lupus erythematosus (SLE) patients without overt thyroid involvement (eight men and 92 women; mean age 40\u00b16.5 years) and 50 age and sex matched controls. All were subjected to thyroid evaluation using anti-thyroglobulin (anti-TG) and anti-thyroid peroxidase (anti-TPO) antibodies; hormones (FT3; FT4 and TSH) and Tc-99m thyroid scintigraphy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>14\/100 (14%) and none (0%) were positive for S-AITD in SLE and control groups, respectively ( P\u2009=\u20090.0001). They were classified by thyroid scintigraphy and hormonal profile into 2\/14 Hashimoto; 10\/14 atrophic thyroiditis and 2\/14 Graves' disease. Anti-TPO was elevated in 12 SLE cases, while anti-TG was elevated in only 2\/14 ( P\u2009=\u20090.0001). Thyroid scintigraphy showed statistically significant associations with FT4, TSH and anti-TPO.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Tc-99m thyroid scintigraphy may have an additional diagnostic role in S-AITD among SLE patients, with an impact on patient management. This potential needs to be further evaluated in a larger series on a multicenter basis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0961203315603137","type":"journal-article","created":{"date-parts":[[2015,9,7]],"date-time":"2015-09-07T22:09:51Z","timestamp":1441663791000},"page":"155-161","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Technetium-99m thyroid scan; does it have a diagnostic aid in sub-clinical auto-immune thyroid disease in systemic lupus erythematosus patients?"],"prefix":"10.1177","volume":"25","author":[{"given":"A","family":"Amin","sequence":"first","affiliation":[{"name":"Nuclear Medicine Department, Faculty of Medicine, Cairo University, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Alkemary","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Faculty of Medicine, Cairo University, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Abdo","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Faculty of Medicine, Cairo University, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Salama","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Department, Faculty of Medicine, Cairo University, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,9,7]]},"reference":[{"key":"bibr1-0961203315603137","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.1.70"},{"key":"bibr2-0961203315603137","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199607113350206"},{"key":"bibr3-0961203315603137","doi-asserted-by":"publisher","DOI":"10.3923\/jms.2006.654.657"},{"key":"bibr4-0961203315603137","first-page":"88","volume":"12","author":"Porkodi R","year":"2004","journal-title":"J Indian Rheumatol Assoc"},{"key":"bibr5-0961203315603137","first-page":"1","volume":"11","author":"Zakeri Z","year":"2010","journal-title":"Shiraz E-Med J"},{"key":"bibr6-0961203315603137","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.080725"},{"key":"bibr7-0961203315603137","doi-asserted-by":"publisher","DOI":"10.3923\/tmr.2012.25.33"},{"key":"bibr8-0961203315603137","doi-asserted-by":"publisher","DOI":"10.3889\/MJMS.1857-5773.2009.0059"},{"key":"bibr9-0961203315603137","first-page":"229","volume":"1","author":"Miller FW","year":"1993","journal-title":"Thyroid"},{"key":"bibr10-0961203315603137","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)80741-3"},{"key":"bibr11-0961203315603137","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5257.909"},{"key":"bibr12-0961203315603137","first-page":"321","volume":"14","author":"Scofield RH","year":"1996","journal-title":"Clin Exp Rheumatol"},{"key":"bibr13-0961203315603137","doi-asserted-by":"publisher","DOI":"10.1136\/ard.48.5.424"},{"key":"bibr14-0961203315603137","first-page":"66","volume-title":"Endocrine system","author":"Ziessman HA","year":"2014","edition":"4"},{"key":"bibr15-0961203315603137","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"bibr16-0961203315603137","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-47953-6"},{"key":"bibr17-0961203315603137","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-010-8245-8"},{"key":"bibr18-0961203315603137","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2009.02.007"},{"key":"bibr19-0961203315603137","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.080725"},{"key":"bibr20-0961203315603137","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8529(05)70189-4"},{"key":"bibr21-0961203315603137","unstructured":"Braverman LE, Utiger RD. 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