{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:02:44Z","timestamp":1777928564109,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2015,9,7]],"date-time":"2015-09-07T00:00:00Z","timestamp":1441584000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:p>Renal tubular acidosis (RTA) is a rare complication of renal involvement of systemic lupus erythematosus (SLE). We describe a 24-year-old male with type IV lupus nephropathy as a presenting manifestation of SLE. He presented with improvement of renal function following induction therapy with three pulses of methylprednisolone and 500\u2009mg biweekly pulses of cyclophosphamide. However, a week after the first pulse of cyclophosphamide, the patient presented with a significant increase in legs edema and severe hyperkalemia. Type IV RTA associated with hyporeninemic hypoaldosteronism was suspected in the presence of metabolic acidosis with a normal anion gap, severe hyperkalemia without worsening renal function, and urinary pH of 5. RTA was confirmed with a transtubular potassium concentration gradient of 2 and low levels of plasma aldosterone, renin, angiotensin II, and cortisol. Intravenous bicarbonate, high-dose furosemide, and fludrocortisone were administered with normalization of potassium levels and renal function.<\/jats:p>","DOI":"10.1177\/0961203315603143","type":"journal-article","created":{"date-parts":[[2015,9,7]],"date-time":"2015-09-07T22:09:51Z","timestamp":1441663791000},"page":"307-309","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Renal tubular acidosis type IV as a complication of lupus nephritis"],"prefix":"10.1177","volume":"25","author":[{"given":"C","family":"S\u00e1nchez-Marcos","sequence":"first","affiliation":[{"name":"Department of Autoimmune Diseases, Hospital Cl\u00ednic, Barcelona, Catalonia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Renal Transplantation, Hospital Cl\u00ednic, Barcelona, Catalonia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Prieto-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Autoimmune Diseases, Hospital Cl\u00ednic, Barcelona, Catalonia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Hern\u00e1ndez-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Autoimmune Diseases, Hospital Cl\u00ednic, Barcelona, Catalonia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Espinosa","sequence":"additional","affiliation":[{"name":"Department of Autoimmune Diseases, Hospital Cl\u00ednic, Barcelona, Catalonia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,9,7]]},"reference":[{"key":"bibr1-0961203315603143","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201940"},{"key":"bibr2-0961203315603143","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh705"},{"key":"bibr3-0961203315603143","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2013.10.013"},{"key":"bibr4-0961203315603143","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-014-2993-3"},{"key":"bibr5-0961203315603143","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2009.02311.x"},{"key":"bibr6-0961203315603143","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c130042"},{"key":"bibr7-0961203315603143","doi-asserted-by":"publisher","DOI":"10.5414\/CNP69306"},{"key":"bibr8-0961203315603143","first-page":"e1","volume":"52","author":"Gera C","year":"2011","journal-title":"Singapore Med J"},{"key":"bibr9-0961203315603143","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2004.07.049"},{"key":"bibr10-0961203315603143","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-5-114"},{"key":"bibr11-0961203315603143","first-page":"73","volume":"8","author":"Akin D","year":"2014","journal-title":"Iran J Kidney Dis"},{"key":"bibr12-0961203315603143","first-page":"560","volume":"28","author":"Lim TK","year":"1987","journal-title":"Singapore Med J"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203315603143","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0961203315603143","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203315603143","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:16:12Z","timestamp":1777677372000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0961203315603143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,7]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1177\/0961203315603143"],"URL":"https:\/\/doi.org\/10.1177\/0961203315603143","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,7]]}}}