{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:02:52Z","timestamp":1777928572657,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2015,11,3]],"date-time":"2015-11-03T00:00:00Z","timestamp":1446508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:p>\n                    We have previously reported the one-year outcomes of 16 children with severe proliferative lupus nephritis (LN) who were treated using a multi-targeted induction protocol based on intravenous (IV) pulse methylprednisolone (MP), mycophenolate mofetil (MMF) and cyclosporine (CSA). This study examined the long-term renal outcomes of these 16 children, followed up for a median duration of 9.2 years (range 5.8\u201314.2 years). Primary treatment outcome was complete renal remission. Secondary outcomes included patient and renal survival as well as relapse-free and event-free survival. All patients achieved complete renal remission within 24 months (median 8.7 months, range 4.0\u201324.0 months). Comparing clinical and laboratory parameters at induction and last follow-up, respectively, Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) score (25.4\u2009\u00b1\u20098.7 vs 0.4\u2009\u00b1\u20090.8), serum complement C3 (47\u2009\u00b1\u200921 vs 107\u2009\u00b1\u200927\u2009mg\/dL), estimated glomerular filtration rate (eGFR) (72\u2009\u00b1\u200957 vs 109.7\u2009\u00b1\u200943\u2009ml\/min\/1.73m\n                    <jats:sup>2<\/jats:sup>\n                    ) and urine protein (6.97\u2009\u00b1\u20097.09 vs 0.2\u2009\u00b1\u20090.02\u2009g\/day\/1.73m\n                    <jats:sup>2<\/jats:sup>\n                    ) improved significantly ( p\u2009&lt;\u20090.05). Kaplan\u2013Meier survival analysis showed a cumulative ten-year renal relapse-free survival of 73.3% when considering relapses with severe proteinuria &gt;1\u2009g\/day\/1.73m\n                    <jats:sup>2<\/jats:sup>\n                    . Cumulative probability that hospitalization would not be required was 93.8% at one year, and 71.4% at ten years. Our multi-targeted protocol for induction and maintenance therapy in Asian children with severe proliferative LN resulted in good long-term patient survival and renal preservation, with a good safety profile.\n                  <\/jats:p>","DOI":"10.1177\/0961203315615220","type":"journal-article","created":{"date-parts":[[2015,11,4]],"date-time":"2015-11-04T20:17:50Z","timestamp":1446668270000},"page":"399-406","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":31,"title":["Long-term outcomes with multi-targeted immunosuppressive protocol in children with severe proliferative lupus nephritis"],"prefix":"10.1177","volume":"25","author":[{"given":"E","family":"Aragon","sequence":"first","affiliation":[{"name":"Shaw-NKF-NUH Children\u2019s Kidney Centre, Khoo Teck Puat-National University Children\u2019s Medical Institute, National University Health System, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L P","family":"Resontoc","sequence":"additional","affiliation":[{"name":"Shaw-NKF-NUH Children\u2019s Kidney Centre, Khoo Teck Puat-National University Children\u2019s Medical Institute, National University Health System, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y H","family":"Chan","sequence":"additional","affiliation":[{"name":"Biostatistics Unit, Yong Loo Lin School of Medicine, National University of Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y W","family":"Lau","sequence":"additional","affiliation":[{"name":"Shaw-NKF-NUH Children\u2019s Kidney Centre, Khoo Teck Puat-National University Children\u2019s Medical Institute, National University Health System, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P H","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Singapore General Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H L","family":"Loh","sequence":"additional","affiliation":[{"name":"Department of Pathology, Singapore General Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K H","family":"Ng","sequence":"additional","affiliation":[{"name":"Shaw-NKF-NUH Children\u2019s Kidney Centre, Khoo Teck Puat-National University Children\u2019s Medical Institute, National University Health System, Singapore"},{"name":"Department of Pediatrics Yong Loo Lin School of Medicine, National University of Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H K","family":"Yap","sequence":"additional","affiliation":[{"name":"Shaw-NKF-NUH Children\u2019s Kidney Centre, Khoo Teck Puat-National University Children\u2019s Medical Institute, National University Health System, Singapore"},{"name":"Department of Pediatrics Yong Loo Lin School of Medicine, National University of Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,11,3]]},"reference":[{"key":"bibr1-0961203315615220","doi-asserted-by":"publisher","DOI":"10.1007\/s004670050034"},{"key":"bibr2-0961203315615220","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(87)90645-0"},{"key":"bibr3-0961203315615220","first-page":"625","volume":"15","author":"Mitjavila F","year":"1997","journal-title":"Clin Exp Rheumatol"},{"key":"bibr4-0961203315615220","first-page":"163","volume":"23","author":"Lee BW","year":"1987","journal-title":"Aust Paediatr 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