{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:02:52Z","timestamp":1777928572753,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2015,11,18]],"date-time":"2015-11-18T00:00:00Z","timestamp":1447804800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate if patients with Primary Antiphospholipid Syndrome (PAPS) with venous and\/or arterial thrombosis without traditional coronary artery disease (CAD) risk factors develop early atherosclerotic vascular damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>27 female patients with PAPS (Sidney criteria) and 27 age, body mass index (BMI), and sex matched controls were consecutively selected. Exclusion criteria were: black race, age \u226555 years, traditional cardiovascular risk factors, other thrombophilias or connective tissue diseases, corticosteroids use and pregnancy. All subjects underwent Pulse Wave Velocity (PWV) and Echo-Tracking (ET), both in carotidal bed, to analyse vascular functional properties.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Age ( p\u2009=\u20090.92) and BMI ( p\u2009=\u20090.91) were comparable in both groups. PAPS patients and controls had similar PWV (9.07\u2009\u00b1\u20091.08\u2009m\/s vs 9.42\u2009\u00b1\u20091.47\u2009m\/s, p\u2009=\u20090.34) as well as echo tracking parameters such as intima-media thickness (683\u2009\u00b1\u2009171\u2009\u00b5m vs 636\u2009\u00b1\u2009140\u2009\u00b5m, p\u2009=\u20090.52), carotideal diameter ( p\u2009=\u20090.26), distensibility ( p\u2009=\u20090.92), compliance coefficients ( p\u2009=\u20090.36) and elastic modulus ( p\u2009=\u20090.78). Patients with exclusively venous thrombosis showed lower PWV than patients with arterial thrombosis (8.55\u2009\u00b1\u20090.70\u2009m\/s vs 9.56\u2009\u00b1\u20090.94\u2009m\/s, p\u2009=\u20090.01), but no difference regarding intima-media thickness (683\u2009\u00b1\u2009171\u2009\u00b5m vs 636\u2009\u00b1\u2009140\u2009\u00b5m, p\u2009=\u20090.52) was observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with PAPS do not seem to be at higher risk of developing premature atherosclerosis. Patients who suffered exclusively venous thrombosis seem to be at lower risk than those with exclusively arterial events. Other studies need to confirm our findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0961203315617841","type":"journal-article","created":{"date-parts":[[2016,1,11]],"date-time":"2016-01-11T14:57:39Z","timestamp":1452524259000},"page":"472-478","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Primary antiphospholipid syndrome: absence of premature atherosclerosis in patients without traditional coronary artery disease risk factors"],"prefix":"10.1177","volume":"25","author":[{"given":"D","family":"Andrade","sequence":"first","affiliation":[{"name":"Rheumatology Division, S\u00e3o Paulo University, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Bortolotto","sequence":"additional","affiliation":[{"name":"Heart Institute of S\u00e3o Paulo University, S\u00e3o Paulo, 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