{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T10:07:21Z","timestamp":1788516441742,"version":"build-2803163510"},"reference-count":38,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2015,12,24]],"date-time":"2015-12-24T00:00:00Z","timestamp":1450915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study was to explore whether the interferon ( IFN)-\u03b3 +874 T\/A polymorphism plays a role in modifying the risk of autoimmune diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A meta-analysis was conducted on the association between the IFN-\u03b3 +874 T\/A polymorphism and autoimmune diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eighteen studies with a total of 2952 patients and 3832 controls were included in the meta-analysis. The meta-analysis revealed no association between autoimmune diseases and the IFN-\u03b3 +874 T allele in all study subjects (odds ratio (OR)=1.023, 95% confidence interval (CI)\u2009=\u20090.894\u20131.171, p\u2009=\u20090.738), but stratification by ethnicity indicated an association between the IFN-\u03b3 +874 T allele and autoimmune diseases in Latin American subjects (OR\u2009=\u20090.780, 95% CI\u2009=\u20090.629\u20130.953, p\u2009=\u20090.015). Meta-analysis also revealed an association between autoimmune diseases and the IFN-\u03b3 +874 T\/A polymorphism in Caucasian and Middle Eastern subjects under a dominant inheritance model (OR\u2009=\u20090.686, 95% CI\u2009=\u20090.489\u20130.964, p\u2009=\u20090.003; OR\u2009=\u20091.414, 95% CI\u2009=\u20091.102\u20131.813, p\u2009=\u20090.006). Meta-analysis by autoimmune disease type indicated an association between ITP and the IFN-\u03b3 +874 T allele (OR\u2009=\u20091.753, 95% CI\u2009=\u20091.228\u20132.503, p\u2009=\u20090.002), but not for vasculitis, vitiligo, and auto-immune thyroid disease. Meta-analysis also showed a significant association between the IFN-\u03b3 +874 T\/A polymorphism and systemic lupus erythematosus (SLE) under the dominant model (OR\u2009=\u20091.668, 95% CI\u2009=\u20091.114\u20132.497, p\u2009=\u20090.013).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This meta-analysis indicates that the IFN-\u03b3 +874 T\/A polymorphism may play a significant role in modifying the risk of autoimmune diseases in Caucasian, Latin American, and Middle Eastern subjects, and in particular shows that the IFN-\u03b3 +874 T\/A polymorphism is associated with increased genetic susceptibility to idiopathic thrombocytopenic purpura and SLE.<\/jats:p>\n                  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