{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:36:27Z","timestamp":1790847387341,"version":"4.1.0"},"reference-count":15,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2016,1,27]],"date-time":"2016-01-27T00:00:00Z","timestamp":1453852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this multicenter study in a large childhood-onset systemic lupus erythematosus (cSLE) population was to assess the herpes zoster infection (HZI) prevalence, demographic data, clinical manifestations, laboratory findings, treatment, and outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective multicenter cohort study (Brazilian cSLE group) was performed in ten Pediatric Rheumatology services in S\u00e3o Paulo State, Brazil, and included 852 cSLE patients. HZI was defined according to the presence of acute vesicular-bullous lesions on erythematous\/edematous base, in a dermatomal distribution. Post-herpetic neuralgia was defined as persistent pain after one month of resolution of lesions in the same dermatome. Patients were divided in two groups for the assessment of current lupus manifestations, laboratory findings, and treatment: patients with HZI (evaluated at the first HZI) and patients without HZI (evaluated at the last visit).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The frequency of HZI in cSLE patients was 120\/852 (14%). Hospitalization occurred in 73 (61%) and overlap bacterial infection in 16 (13%). Intravenous or oral aciclovir was administered in 113\/120 (94%) cSLE patients at HZI diagnosis. None of them had ophthalmic complication or death. Post-herpetic neuralgia occurred in 6\/120 (5%). After Holm\u2013Bonferroni correction for multiple comparisons, disease duration (1.58 vs 4.41 years, p\u2009&lt;\u20090.0001) was significantly lower in HZI cSLE patients compared to those without HZI. Nephritis (37% vs 18%, p\u2009&lt;\u20090.0001), lymphopenia (32% vs 17%, p\u2009&lt;\u20090.0001) prednisone (97% vs 77%, p\u2009&lt;\u20090.0001), cyclophosphamide (20% vs 5%, p\u2009&lt;\u20090.0001) and SLE Disease Activity Index 2000 (6.0 (0\u201335) vs 2 (0\u201345), p\u2009&lt;\u20090.0001) were significantly higher in the former group. The logistic regression model showed that four independent variables were associated with HZI: disease duration\u2009&lt;\u20091 year (OR 2.893 (CI 1.821\u20134.597), p\u2009&lt;\u20090.0001), lymphopenia &lt;1500\/mm\n                      <jats:sup>3<\/jats:sup>\n                      (OR 1.931 (CI 1.183\u20133.153), p\u2009=\u20090.009), prednisone (OR 6.723 (CI 2.072\u201321.815), p\u2009=\u20090.002), and cyclophosphamide use (OR 4.060 (CI 2.174\u20137.583), p\u2009&lt;\u20090.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HZI is an early viral infection in cSLE with a typical dermatomal distribution. Lymphopenia and immunosuppressive treatment seem to be major factors underlying this complication in spite of a benign course.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0961203315627203","type":"journal-article","created":{"date-parts":[[2016,1,28]],"date-time":"2016-01-28T20:38:49Z","timestamp":1454013529000},"page":"754-759","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":37,"title":["Herpes zoster infection in childhood-onset systemic lupus erythematosus patients: a large multicenter study"],"prefix":"10.1177","volume":"25","author":[{"given":"J C O A","family":"Ferreira","sequence":"first","affiliation":[{"name":"Pediatric Rheumatology Unit, Faculdade de Medicina da Universidade de S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H H","family":"Marques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M P L","family":"Ferriani","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology Unit, Faculdade de Medicina da Universidade de S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N W S","family":"Gormezano","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology Unit, Faculdade de Medicina da Universidade de S\u00e3o Paulo, Brazil"},{"name":"Division of Rheumatology, Faculdade de Medicina da Universidade de S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M T","family":"Terreri","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology Unit, Universidade Federal de S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R M","family":"Pereira","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Faculdade de Medicina da Universidade de S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C S","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology Unit, S\u00e3o Paulo State University (UNESP), Faculdade de Medicina de Botucatu, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L M","family":"Campos","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology Unit, Faculdade de Medicina da Universidade de S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Bugni","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology Unit, Universidade Federal de S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E M","family":"Okuda","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology Unit, Irmandade da Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Marini","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology Unit, State University of Campinas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G S","family":"Pileggi","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology Unit, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C M","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology Unit, Hospital Infantil Darcy Vargas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Bonf\u00e1","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Faculdade de Medicina da Universidade de S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C A","family":"Silva","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology Unit, Faculdade de Medicina da Universidade de S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,1,27]]},"reference":[{"key":"bibr1-0961203315627203","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000756"},{"key":"bibr2-0961203315627203","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000226841.03751.1f"},{"key":"bibr3-0961203315627203","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2006005000110"},{"key":"bibr4-0961203315627203","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2013.08.009"},{"key":"bibr5-0961203315627203","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"bibr6-0961203315627203","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21757"},{"key":"bibr7-0961203315627203","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199904)42:4<599::AID-ANR2>3.0.CO;2-F"},{"key":"bibr8-0961203315627203","doi-asserted-by":"publisher","DOI":"10.1177\/0961203309106917"},{"key":"bibr9-0961203315627203","doi-asserted-by":"publisher","DOI":"10.1542\/peds.114.S2.555"},{"key":"bibr10-0961203315627203","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002231"},{"key":"bibr11-0961203315627203","first-page":"S1","volume":"39","author":"National Kidney Foundation","year":"2002","journal-title":"Am J Kidney Dis"},{"key":"bibr12-0961203315627203","first-page":"288","volume":"29","author":"Gladman DD","year":"2002","journal-title":"J Rheumatol"},{"key":"bibr13-0961203315627203","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780390303"},{"key":"bibr14-0961203315627203","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.1999.00490.x"},{"key":"bibr15-0961203315627203","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0b013e3181d52ed7"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203315627203","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0961203315627203","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203315627203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:16:36Z","timestamp":1777677396000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0961203315627203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,27]]},"references-count":15,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1177\/0961203315627203"],"URL":"https:\/\/doi.org\/10.1177\/0961203315627203","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,27]]}}}