{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:11:25Z","timestamp":1780470685543,"version":"3.54.1"},"reference-count":43,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2016,2,4]],"date-time":"2016-02-04T00:00:00Z","timestamp":1454544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aims of this study were to analyze the pulmonary function of childhood-onset systemic lupus erythematosus (cSLE) patients and to identify possible correlations between the high-resolution computed chest tomography (HRCT) score, disease activity, disease cumulative damage, and the participants\u2019 quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty cSLE patients, median age: 14.1 years (range: 7.4\u201317.9), underwent spirometry and plethysmography. Carbon monoxide diffusing capacity (DLCO), HRCT, disease activity, disease cumulative damage, and quality of life were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Pulmonary abnormalities were evident in 19\/40 (47.5%) cSLE patients according to spirometry\/DLCO. Forced expired volume in one second (FEV\n                      <jats:sub>1<\/jats:sub>\n                      %) was the parameter most affected (30%). The HRCT showed some abnormality in 22\/30 patients (73%), which were minimal in 43%. Signs of airway affects were found in 50%. Twelve patients were hospitalized due to cSLE-related pulmonary complications before the study began (median discharge: 2.1 years earlier). Total lung capacity (TLC%), vital capacity (VC%), forced vital capacity (FVC%), and FEV\n                      <jats:sub>1<\/jats:sub>\n                      % were significantly lower in the group with hospitalization compared to the group without hospitalization ( p\u2009=\u20090.0025, p\u2009=\u20090.0022, p\u2009=\u20090.0032, and p\u2009=\u20090.0004, respectively). Of note, DLCO was positively correlated with disease duration ( r\u2009=\u2009+0.4; p\u2009=\u20090.01). The HRCT-score was negatively correlated with FEV\n                      <jats:sub>1<\/jats:sub>\n                      \/VC ( r\u2009=\u2009\u22120.63; p\u2009=\u20090.0002), FEV\n                      <jats:sub>1<\/jats:sub>\n                      ( r\u2009=\u2009\u22120.54; p\u2009=\u20090.018), FEF\n                      <jats:sub>25%\u201375%<\/jats:sub>\n                      ( r\u2009=\u2009\u22120.67; p\u2009&lt;\u20090.0001), and HRCT-score was positively correlated with resistance ( r\u2009=\u2009+0.49; p\u2009=\u20090.0056).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Almost half of patients with cSLE had subclinical pulmonary abnormalities, especially airway abnormalities. The cSLE-related pulmonary complications seem to determine long-term functional damage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0961203316629554","type":"journal-article","created":{"date-parts":[[2016,2,5]],"date-time":"2016-02-05T20:32:45Z","timestamp":1454704365000},"page":"645-651","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Subclinical pulmonary abnormalities in childhood-onset systemic lupus erythematosus patients"],"prefix":"10.1177","volume":"25","author":[{"given":"C S","family":"Veiga","sequence":"first","affiliation":[{"name":"Pediatric Pulmonology Unit, Instituto da Crian\u00e7a do Hospital das Cl\u00ednicas, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D S","family":"Coutinho","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology Unit, Instituto da Crian\u00e7a do Hospital das Cl\u00ednicas, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C M A","family":"Nakaie","sequence":"additional","affiliation":[{"name":"Pediatric Pulmonology Unit, Instituto da Crian\u00e7a do Hospital das Cl\u00ednicas, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L M A","family":"Campos","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology Unit, Instituto da Crian\u00e7a do Hospital das Cl\u00ednicas, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Radiology, Instituto da Crian\u00e7a do Hospital das Cl\u00ednicas, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, 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