{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:03:04Z","timestamp":1777928584305,"version":"3.51.4"},"reference-count":50,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2016,2,27]],"date-time":"2016-02-27T00:00:00Z","timestamp":1456531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with systemic lupus erythematosus (SLE) have a higher risk for cardiovascular disease (CVD), not fully explained by the conventional risk factors. These patients have endothelial dysfunction (ED) as an early process of atherosclerosis, which can be reversed with therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the effect of ezetimibe plus pravastatin on endothelial function in patients with SLE after 12 months of treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>An open study, before and after, which assessed the effect of ezetimibe plus pravastatin treatment, was performed. Twenty two patients (21 women and one man) with diagnosis of SLE were studied, with a mean age 40\u2009\u00b1\u20095 years. Endothelial dysfunction was evaluated using vascular ultrasound of the brachial artery in order to measure the flow-mediated vasodilation (FMV) basal and after 12 months of treatment with pravastatin 40\u2009mg\/day plus ezetimibe 10\u2009mg\/day. In addition, a lipid profile: total cholesterol (TC), HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), and serum C-reactive protein (CRP), was done.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found a basal FMV of 7.58% and 18.22% after 12 months of treatment, with an improvement of 10.64 points 95% CI (7.58\u201313.58), p\u2009&lt;\u20090.001. TC decreased from 201.3\u2009\u00b1\u200958.9\u2009mg\/dL to 158.06\u2009\u00b1\u200950.13\u2009mg\/dL ( p\u2009&lt;\u20090.01); LDL-C from 125.78\u2009\u00b1\u200944.4\u2009mg\/dL to 78.8\u2009\u00b1\u200932.9\u2009mg\/dL ( p\u2009&lt;\u20090.001); HDL-C increased from 49.0\u2009\u00b1\u200916.8\u2009mg\/dL to 52.2\u2009\u00b1\u200913.8\u2009mg\/dL ( p\u2009=\u20090.077). The basal and final concentrations of CRP were 4.49 and 2.8, respectively, with a mean decrease of 2.11\u2009mg\/dL, 95% CI (0.908\u20133.32), p\u2009&lt;\u20090.002. Both drugs were well tolerated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Ezetimibe plus pravastatin significantly improved FMV in patients with SLE, decreasing ED and the lipid profile. This treatment ameliorated an early process of atherosclerosis and a risk factor for CVD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0961203316631631","type":"journal-article","created":{"date-parts":[[2016,2,28]],"date-time":"2016-02-28T21:03:30Z","timestamp":1456693410000},"page":"741-748","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of ezetimibe plus pravastatin on endothelial dysfunction in patients with systemic lupus erythematosus"],"prefix":"10.1177","volume":"25","author":[{"given":"O","family":"Vera-Lastra","sequence":"first","affiliation":[{"name":"Internal Medicine Department, Hospital de Especialidades \u201cDr Antonio Fraga Mouret\u201d, Centro M\u00e9dico Nacional La Raza, Instituto Mexicano del Seguro Social, Mexico City, Mexico"},{"name":"Postgraduate Studies Division, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"M\u00e9ndez-Flores","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital de Especialidades \u201cDr Antonio Fraga Mouret\u201d, Centro M\u00e9dico Nacional La Raza, Instituto Mexicano del Seguro Social, Mexico City, Mexico"},{"name":"Postgraduate Studies Division, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M P","family":"Cruz-Dominguez","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital de Especialidades \u201cDr Antonio Fraga Mouret\u201d, Centro M\u00e9dico Nacional La Raza, Instituto Mexicano del Seguro Social, Mexico City, Mexico"},{"name":"Postgraduate Studies Division, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Medina","sequence":"additional","affiliation":[{"name":"Clinical Research Unit, Hospital de Especialidades \u201cDr Antonio Fraga Mouret\u201d, Centro M\u00e9dico Nacional La Raza, Instituto Mexicano del Seguro Social, Mexico City, Mexico"},{"name":"Postgraduate Studies Division, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Calder\u00f3n-Aranda","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital de Especialidades \u201cDr Antonio Fraga Mouret\u201d, Centro M\u00e9dico Nacional La Raza, Instituto Mexicano del Seguro Social, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L J","family":"Jara","sequence":"additional","affiliation":[{"name":"Direction of Education and Research, Hospital de Especialidades \u201cDr Antonio Fraga Mouret\u201d, Centro M\u00e9dico Nacional La Raza, Instituto Mexicano del Seguro Social, Mexico City, Mexico"},{"name":"Postgraduate Studies Division, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,2,27]]},"reference":[{"key":"bibr1-0961203316631631","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200110)44:10<2331::AID-ART395>3.0.CO;2-I"},{"key":"bibr2-0961203316631631","doi-asserted-by":"publisher","DOI":"10.2174\/157340308784245775"},{"key":"bibr3-0961203316631631","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009122"},{"key":"bibr4-0961203316631631","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199901)42:1<51::AID-ANR7>3.0.CO;2-D"},{"key":"bibr5-0961203316631631","first-page":"288","volume":"30","author":"Bruce IN","year":"2003","journal-title":"J Rheumatol"},{"key":"bibr6-0961203316631631","doi-asserted-by":"crossref","unstructured":"Sincer \u0110, Kurto\u011flu E, Y\u0131lmaz \u00c7o\u015fkun F, et\u00a0al. 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