{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:04:34Z","timestamp":1791576274933,"version":"4.3.4"},"reference-count":52,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2016,7,19]],"date-time":"2016-07-19T00:00:00Z","timestamp":1468886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Systemic lupus erythematosus (SLE) is associated with elevated levels of S100A8\/A9, pro-inflammatory proteins mainly secreted by activated polymorphonuclear neutrophils (PMNs). The underlying mechanisms for increased S100A8\/A9 levels and their relation to the clinical phenotype have not been carefully investigated. We assessed S100A8\/A9 and S100A12 levels in SLE patient sera in relation to disease activity, clinical phenotype, presence of anti-dsDNA antibodies and ability to promote phagocytosis of necrotic cells (NCs) by PMNs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Serum levels of S100A8\/A9 and S100A12 were measured by ELISA in paired samples of 100 SLE patients at time points of higher and lower disease activity. Serum-mediated phagocytosis of NCs by PMNs was analysed by flow cytometry. Clinical data were recorded at time points of blood sampling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Serum levels of S100A8\/A9 and S100A12 were increased in SLE patients with high disease activity compared to paired samples at low disease activity ( p\u2009=\u20090.01 and p\u2009=\u20090.008, respectively). Elevated levels of S100A8\/A9 were particularly seen in patients with anti-dsDNA antibodies ( p\u2009=\u20090.01) and glomerulonephritis before treatment ( p\u2009=\u20090.02). Immunosuppressive therapy was associated with a reduction of S100A8\/A9 serum levels ( p\u2009=\u20090.002). The ability of serum to support phagocytosis of NCs by PMNs was related to increased S100A8\/A9 levels ( p\u2009=\u20090.01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Elevated serum levels of S100A8\/A9 may be used to monitor disease activity and response to treatment in SLE patients, especially in patients with glomerulonephritis. S100A12 may be a marker of disease activity in SLE. Increased S100A8\/A9 levels may reflect immune-pathological processes involving phagocytosis of immune complexes by PMNs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0961203316655208","type":"journal-article","created":{"date-parts":[[2016,7,12]],"date-time":"2016-07-12T21:53:27Z","timestamp":1468360407000},"page":"139-149","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":60,"title":["Pro-inflammatory S100 proteins are associated with glomerulonephritis and anti-dsDNA antibodies in systemic lupus erythematosus"],"prefix":"10.1177","volume":"26","author":[{"given":"H","family":"Tyd\u00e9n","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Division of Rheumatology, Lund University and Sk\u00e5ne University Hospital, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Lood","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Division of Rheumatology, Lund University and Sk\u00e5ne University Hospital, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Gullstrand","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Division of Rheumatology, Lund University and Sk\u00e5ne University Hospital, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"J\u00f6nsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Division of Rheumatology, Lund University and Sk\u00e5ne University Hospital, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Ivars","sequence":"additional","affiliation":[{"name":"Department of Experimental Medical Science, Immunology Group, Lund University, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Leanderson","sequence":"additional","affiliation":[{"name":"Department of Experimental Medical Science, Immunology Group, Lund University, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A A","family":"Bengtsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Division of Rheumatology, Lund University and Sk\u00e5ne University Hospital, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,7,19]]},"reference":[{"key":"bibr1-0961203316655208","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200001)43:1<76::AID-ANR10>3.0.CO;2-I"},{"key":"bibr2-0961203316655208","doi-asserted-by":"publisher","DOI":"10.1084\/jem.179.4.1317"},{"key":"bibr3-0961203316655208","doi-asserted-by":"publisher","DOI":"10.1191\/096120398678919804"},{"key":"bibr4-0961203316655208","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199807)41:7<1241::AID-ART15>3.0.CO;2-H"},{"key":"bibr5-0961203316655208","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-200209000-00003"},{"key":"bibr6-0961203316655208","first-page":"25","volume":"23","author":"Hargraves MM","year":"1948","journal-title":"Proc Staff Meet Mayo Clin"},{"key":"bibr7-0961203316655208","doi-asserted-by":"publisher","DOI":"10.1172\/JCI103805"},{"key":"bibr8-0961203316655208","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199808)41:8<1446::AID-ART15>3.0.CO;2-6"},{"key":"bibr9-0961203316655208","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.111511"},{"key":"bibr10-0961203316655208","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200002)43:2<420::AID-ANR24>3.0.CO;2-Z"},{"key":"bibr11-0961203316655208","doi-asserted-by":"publisher","DOI":"10.1080\/08916930310001630325"},{"key":"bibr12-0961203316655208","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(03)00062-0"},{"key":"bibr13-0961203316655208","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.14.9496"},{"key":"bibr14-0961203316655208","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12986-8"},{"key":"bibr15-0961203316655208","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-008-0097-7"},{"key":"bibr16-0961203316655208","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00380"},{"key":"bibr17-0961203316655208","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000639"},{"key":"bibr18-0961203316655208","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092385"},{"key":"bibr19-0961203316655208","doi-asserted-by":"publisher","DOI":"10.1038\/nm1638"},{"key":"bibr20-0961203316655208","doi-asserted-by":"publisher","DOI":"10.1038\/ncprheum0531"},{"key":"bibr21-0961203316655208","doi-asserted-by":"publisher","DOI":"10.1038\/nri1594"},{"key":"bibr22-0961203316655208","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80801-6"},{"key":"bibr23-0961203316655208","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keg385"},{"key":"bibr24-0961203316655208","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.6.847"},{"key":"bibr25-0961203316655208","doi-asserted-by":"publisher","DOI":"10.1002\/art.20631"},{"key":"bibr26-0961203316655208","doi-asserted-by":"publisher","DOI":"10.1177\/096120339300200108"},{"key":"bibr27-0961203316655208","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.081302"},{"key":"bibr28-0961203316655208","doi-asserted-by":"publisher","DOI":"10.1186\/ar3314"},{"key":"bibr29-0961203316655208","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2015.06.025"},{"key":"bibr30-0961203316655208","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket263"},{"key":"bibr31-0961203316655208","first-page":"288","volume":"29","author":"Gladman DD","year":"2002","journal-title":"J Rheumatol"},{"key":"bibr32-0961203316655208","doi-asserted-by":"publisher","DOI":"10.1002\/art.21625"},{"key":"bibr33-0961203316655208","doi-asserted-by":"publisher","DOI":"10.3109\/03009742.2013.799224"},{"key":"bibr34-0961203316655208","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/17.11.1909"},{"key":"bibr35-0961203316655208","doi-asserted-by":"publisher","DOI":"10.3109\/00365513.2010.543143"},{"key":"bibr36-0961203316655208","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00443.x"},{"key":"bibr37-0961203316655208","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780251101"},{"key":"bibr38-0961203316655208","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.53.3.259"},{"key":"bibr39-0961203316655208","doi-asserted-by":"publisher","DOI":"10.1007\/BF02205555"},{"key":"bibr40-0961203316655208","doi-asserted-by":"publisher","DOI":"10.1177\/0961203315598015"},{"key":"bibr41-0961203316655208","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.9.5837"},{"key":"bibr42-0961203316655208","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203923"},{"key":"bibr43-0961203316655208","doi-asserted-by":"publisher","DOI":"10.1159\/000233593"},{"key":"bibr44-0961203316655208","doi-asserted-by":"publisher","DOI":"10.1080\/08916930400022954"},{"key":"bibr45-0961203316655208","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.36.25291"},{"key":"bibr46-0961203316655208","first-page":"280","volume":"14","author":"Camussi G","year":"1980","journal-title":"Clin Nephrol"},{"key":"bibr47-0961203316655208","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0902199"},{"key":"bibr48-0961203316655208","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-013-0375-7"},{"key":"bibr49-0961203316655208","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205365"},{"key":"bibr50-0961203316655208","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3001201"},{"key":"bibr51-0961203316655208","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2011.132"},{"key":"bibr52-0961203316655208","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3001180"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203316655208","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0961203316655208","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203316655208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:17:12Z","timestamp":1777677432000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0961203316655208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,19]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1177\/0961203316655208"],"URL":"https:\/\/doi.org\/10.1177\/0961203316655208","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,19]]}}}