{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:03:32Z","timestamp":1777928612588,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2016,8,20]],"date-time":"2016-08-20T00:00:00Z","timestamp":1471651200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease. However, the exact mechanism underlying SLE-related osteopenia and osteoporosis in patients newly diagnosed with SLE remains unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>60 male subjects with SLE aged 20\u201330 years were enrolled. Serum osteocalcin was examined as a marker of bone formation and type I collagen degradation products (\u03b2-crosslaps) as markers of bone resorption. Lumbar spine (L1-L4) and total hip bone mineral density (BMD) were determined by dual energy X-ray absorption (DXA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 60 subjects with SLE at the time of diagnosis, the cohort showed a significant reduction of osteocalcin (12.62\u2009\u00b1\u20092.16\u2009ng\/mL), and serum \u03b2-crosslaps level (992.6\u2009\u00b1\u2009162.6\u2009pg\/mL) was markedly elevated. Univariate correlation analyses revealed negative correlations between osteocalcin and SLEDAI, dsDNA antibody and \u03b2-crosslaps. A positive correlation was also observed between osteocalcin and C3, C4, 25-OH vitamin D, BMD L1\u2013L4 and BMD total hip (see Table 3). Osteocalcin and \u03b2-crosslaps were strongly associated with SLE disease activity by multiple stepwise logistic regression analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Osteocalcin was negatively associated with SLE disease activity, and \u03b2-crosslaps was positively associated with SLE disease activity, suggesting SLE disease activity itself directly contributed to the development of SLE-associated osteopenia and osteoporosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0961203316664596","type":"journal-article","created":{"date-parts":[[2016,8,13]],"date-time":"2016-08-13T20:38:34Z","timestamp":1471120714000},"page":"289-293","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Assessment of bone mineral density and bone metabolism in young male adults recently diagnosed with systemic lupus erythematosus in China"],"prefix":"10.1177","volume":"26","author":[{"given":"Qinyue","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Respiratory, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, China"},{"name":"Critical Care Medicine, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shufang","family":"Wu","sequence":"additional","affiliation":[{"name":"Center for Translational Medicine, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongzhi","family":"Sun","sequence":"additional","affiliation":[{"name":"Key Laboratory of Environment and Genes Related to Diseases, Medical School of Xi\u2019an Jiaotong University, Xi\u2019an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"He","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Respiratory, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,8,20]]},"reference":[{"key":"bibr1-0961203316664596","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-012-2389-1"},{"key":"bibr2-0961203316664596","doi-asserted-by":"publisher","DOI":"10.1136\/ard.59.4.308"},{"key":"bibr3-0961203316664596","doi-asserted-by":"publisher","DOI":"10.1177\/0961203313502861"},{"key":"bibr4-0961203316664596","first-page":"45","volume":"76","author":"Korczowska I","year":"2003","journal-title":"Yale J Biol 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