{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:35:33Z","timestamp":1791858933576,"version":"4.3.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2016,10,23]],"date-time":"2016-10-23T00:00:00Z","timestamp":1477180800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:p>Juvenile systemic lupus erythematosus (JSLE) is a complex multisystemic autoimmune disorder of unknown cause. It accounts for about one in five cases of SLE. The tendency for SLE to run a fulminant course when it starts in childhood has made JSLE a potentially more severe disease than adult SLE. Reports of JSLE from sub-Saharan Africa are scanty in spite of the increasing reports of adult SLE. We conducted a 4-year retrospective study of JSLE cases seen at the Lagos State University Teaching Hospital between January 2010 and December 2014. Out of the 12 patients studied, eight were girls and four were boys. All patients had positive antinuclear antibody and extractable nuclear antibody tests. Anti-dsDNA antibody was positive in 10 patients. Eight patients had renal disease while four patients had neuropsychiatric manifestations. Haematological abnormalities and constitutional symptoms were present in all patients. Patients were treated with pulse methylprednisolone, oral prednisolone, hydroxychloroquine and azathioprine. Three patients also received rituximab. In conclusion, JSLE exists in Nigeria and exhibits clinical and immunological characteristics similar to its pattern in other parts of the world. It is, however, diagnosed late and is possibly being underdiagnosed as there is no paediatric rheumatologist in the country.<\/jats:p>","DOI":"10.1177\/0961203316672927","type":"journal-article","created":{"date-parts":[[2016,10,22]],"date-time":"2016-10-22T20:17:43Z","timestamp":1477167463000},"page":"329-333","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Juvenile systemic lupus erythematosus in Nigeria"],"prefix":"10.1177","volume":"26","author":[{"given":"O O","family":"Adelowo","sequence":"first","affiliation":[{"name":"Department of Medicine, Lagos State University Teaching Hospital, Ikeja, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B H","family":"Olaosebikan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Lagos State University Teaching Hospital, Ikeja, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B A","family":"Animashaun","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Lagos State University Teaching Hospital, Ikeja, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R O","family":"Akintayo","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Ilorin Teaching Hospital, Ilorin, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,10,23]]},"reference":[{"key":"bibr1-0961203316672927","first-page":"1981","volume":"23","author":"Malleson P","year":"1996","journal-title":"J Rheumatol"},{"key":"bibr2-0961203316672927","doi-asserted-by":"publisher","DOI":"10.1177\/0961203315584413"},{"key":"bibr3-0961203316672927","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-4-13"},{"key":"bibr4-0961203316672927","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21757"},{"key":"bibr5-0961203316672927","first-page":"S474","volume":"7","author":"Manzi S","year":"2001","journal-title":"Am J Manag Care"},{"key":"bibr6-0961203316672927","first-page":"274","volume":"38","author":"Cabral M","year":"2013","journal-title":"Acta Reumatol Port"},{"key":"bibr7-0961203316672927","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-014-2841-6"},{"key":"bibr8-0961203316672927","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780251101"},{"key":"bibr9-0961203316672927","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199904)42:4<599::AID-ANR2>3.0.CO;2-F"},{"key":"bibr10-0961203316672927","doi-asserted-by":"publisher","DOI":"10.1586\/eci.09.29"},{"key":"bibr11-0961203316672927","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(02)00015-7"},{"key":"bibr12-0961203316672927","first-page":"777","volume":"99","author":"Olowu W","year":"2007","journal-title":"J Natl Med Assoc"},{"key":"bibr13-0961203316672927","first-page":"365","volume":"24","author":"Tavangar-Rad F","year":"2014","journal-title":"Iran J Pediatr"},{"key":"bibr14-0961203316672927","first-page":"1168","volume":"17","author":"el-Garf A","year":"1990","journal-title":"J Rheumatol"},{"key":"bibr15-0961203316672927","doi-asserted-by":"publisher","DOI":"10.1186\/1546-0096-10-38"},{"key":"bibr16-0961203316672927","doi-asserted-by":"publisher","DOI":"10.1007\/BF00197521"},{"key":"bibr17-0961203316672927","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/34.9.866"},{"key":"bibr18-0961203316672927","doi-asserted-by":"publisher","DOI":"10.1177\/0961203307084297"},{"key":"bibr19-0961203316672927","doi-asserted-by":"publisher","DOI":"10.1177\/0961203315606983"},{"key":"bibr20-0961203316672927","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-009-1139-6"},{"key":"bibr21-0961203316672927","doi-asserted-by":"publisher","DOI":"10.1186\/ar4256"},{"key":"bibr22-0961203316672927","doi-asserted-by":"publisher","DOI":"10.1177\/0961203312443421"},{"key":"bibr23-0961203316672927","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-1640"},{"key":"bibr24-0961203316672927","doi-asserted-by":"publisher","DOI":"10.1136\/ard.40.4.325"},{"key":"bibr25-0961203316672927","first-page":"497","volume":"91","author":"Gedalia A","year":"1999","journal-title":"J Natl Med Assoc"},{"key":"bibr26-0961203316672927","doi-asserted-by":"publisher","DOI":"10.4103\/1319-2442.152493"},{"key":"bibr27-0961203316672927","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20179"},{"key":"bibr28-0961203316672927","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21779"},{"key":"bibr29-0961203316672927","unstructured":"European League Against Rheumatism. Air pollution exposure may worsen lupus in children: not just a respiratory and cardiovascular issue.\n                      Science Daily\n                      , 9 June 2016. www.sciencedaily.com\/releases\/2016\/06\/160609115429.htm."}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203316672927","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0961203316672927","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203316672927","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:17:33Z","timestamp":1777677453000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0961203316672927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,23]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1177\/0961203316672927"],"URL":"https:\/\/doi.org\/10.1177\/0961203316672927","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,23]]}}}