{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T22:45:53Z","timestamp":1789771553831,"version":"4.0.1"},"reference-count":21,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2016,10,31]],"date-time":"2016-10-31T00:00:00Z","timestamp":1477872000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of this study was to describe the demographic, clinical, and immunological manifestations of systemic lupus erythematosus (SLE) in male patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross-sectional, multicenter study was carried out of 3651 patients (353 men, 9.7%, and 3298 women, 90.2%) diagnosed with SLE, included in the Spanish Rheumatology Society SLE Registry (RELESSER).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mean ages (18\u201392 years) of symptom onset were 37 (SD 17) years (men) and 32 (SD 14) years (women). Male\/female ratio was 1\/9. Age of onset of symptoms and age at diagnosis were higher in men than in women ( p\u2009&lt;\u20090.001). Males were diagnosed earlier than females (p\u2009=\u20090.04) and had more cardiovascular comorbidities ( p\u2009&lt;\u20090.001). Two hundred and thirty-six males (68%) with SLE required hospitalization in comparison with 1713 females (53%) ( p\u2009&lt;\u20090.001). During follow-up, 208 patients died: 30 men (9.3%) and 178 women (5.9%) ( p\u2009=\u20090.02). As regards clinical manifestations, loss of weight ( p\u2009=\u20090.01), lymphadenopathies ( p\u2009=\u20090.02), and splenomegaly ( p\u2009=\u20090.02) were more common in male patients. Female patients were more likely to have inflammatory rash, alopecia, and arthritis ( p\u2009&lt;\u20090.05). As for lung involvement, men with SLE had more pleural fibrosis ( p\u2009&lt;\u20090.001) and pulmonary embolism ( p\u2009=\u20090.01). However, Raynaud\u2019s phenomenon was more common in women (35%) than in men (23.7%) ( p\u2009&lt;\u20090.001); lupus nephritis was more common in men, being present in 155 (44.8%) of males versus 933 (29%) of females ( p\u2009&lt;\u20090.001). Multivariate analysis showed that SLE patients with a high Charlson index (more than 3 points) and age\u2009&gt;\u200950 years had a higher mortality (odds ratios 3.6 and 2.1, respectively). Furthermore, SLE patients who developed pulmonary hemorrhage, pulmonary hypertension, psychiatric involvement, complement deficiency, and hemophagocytic syndrome also had higher mortality, regardless of gender.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with SLE over the age of 50 years have an increased risk of mortality. In Caucasians, age at diagnosis and symptom onset is higher in men than in women. The diagnostic delay is shorter in men. Male SLE patients present more cardiovascular comorbidities, and also more serositis, adenopathies, splenomegaly, renal involvement, convulsion, thrombosis, and lupus anticoagulant positivity than women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0961203316673728","type":"journal-article","created":{"date-parts":[[2016,10,31]],"date-time":"2016-10-31T20:49:43Z","timestamp":1477946983000},"page":"698-706","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":60,"title":["Systemic lupus erythematosus in Spanish males: a study of the Spanish Rheumatology Society Lupus Registry (RELESSER) cohort"],"prefix":"10.1177","volume":"26","author":[{"given":"A","family":"Riveros Frutos","sequence":"first","affiliation":[{"name":"Rheumatology Department, Germans Trias i Pujol University Hospital, Badalona, Spain"},{"name":"Medicine Department, UAB, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Casas","sequence":"additional","affiliation":[{"name":"Preventive Department, Germans Trias i Pujol University Hospital, Badalona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"R\u00faa-Figueroa","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Doctor Negr\u00edn University Hospital of Gran Canaria, Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F J","family":"L\u00f3pez-Longo","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Gregorio Mara\u00f1\u00f3n University Hospital, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Calvo-Al\u00e9n","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Sierrallana Hospital, Torrelavega, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Galindo","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Doce de Octubre University Hospital, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Fern\u00e1ndez-Nebro","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Carlos Haya University Hospital, M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J M","family":"Pego-Reigosa","sequence":"additional","affiliation":[{"name":"Rheumatology Department, University Hospital Complex Instituto de Investigaci\u00f3n Biom\u00e9dica de Vigo (IBIV), Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Oliv\u00e9 Marqu\u00e9s","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Germans Trias i Pujol University Hospital, Badalona, 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