{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:46:29Z","timestamp":1780472789760,"version":"3.54.1"},"reference-count":12,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2016,11,12]],"date-time":"2016-11-12T00:00:00Z","timestamp":1478908800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Cutaneous manifestations of pediatric systemic lupus erythematosus cause significant morbidity. Lenalidomide, a thalidomide analogue, has shown promise treating cutaneous lupus erythematosus in adults. Our objective was to evaluate lenalidomide\u2019s efficacy and safety in treating refractory cutaneous manifestations of pediatric systemic lupus erythematosus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective chart review of 10 adolescents who received lenalidomide for recalcitrant cutaneous lupus erythematosus. Information was gathered at drug initiation and 6-month follow-up. The Wilcoxon matched-pairs signed-rank test was used to assess change in quantitative parameters of disease activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nine subjects were girls and six were African-American. Indications for lenalidomide treatment included alopecia, nasal and oral ulcers, extensive malar rash, discoid lesions, bullous lesions, panniculitis, cutaneous vasculitis, and Raynaud\u2019s phenomenon with digital ulcerations. Within 6 months, all patients demonstrated complete or near resolution based on physician report. Prednisone dose decreased from a mean 23.5\u2009mg (SD\u00b1\u200913.3) to 12.25\u2009mg (SD\u00b1\u20099.2) ( P=\u20090.008). Sedimentation rate decreased from a mean 29\u2009mm\/hour (SD\u00b1\u200931.5) to 17\u2009mm\/hour (SD\u00b1\u200918.1) ( P=\u20090.004). Lenalidomide was well tolerated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Lenalidomide is an effective and safe treatment for a spectrum of dermatological conditions in pediatric systemic lupus erythematosus. Its use may allow a reduction in prednisone dose and decreased disfigurement. Prospective study is needed to clarify lenalidomide\u2019s role in treating cutaneous manifestations of systemic lupus erythematosus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0961203316676377","type":"journal-article","created":{"date-parts":[[2016,11,11]],"date-time":"2016-11-11T20:26:35Z","timestamp":1478895995000},"page":"646-649","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Lenalidomide for refractory cutaneous manifestations of pediatric systemic lupus erythematosus"],"prefix":"10.1177","volume":"26","author":[{"given":"E Y","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Pediatrics, The University of North Carolina at Chapel Hill, Chapel Hill, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L E","family":"Schanberg","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Duke University Medical Center, Durham, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E C","family":"Wershba","sequence":"additional","affiliation":[{"name":"Phoenix Children\u2019s Medical Group, Phoenix, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C E","family":"Rabinovich","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Duke University Medical Center, Durham, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,11,12]]},"reference":[{"key":"bibr1-0961203316676377","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200304070-00002"},{"key":"bibr2-0961203316676377","doi-asserted-by":"publisher","DOI":"10.2165\/11310780-000000000-00000"},{"key":"bibr3-0961203316676377","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.06.018"},{"key":"bibr4-0961203316676377","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.06.017"},{"key":"bibr5-0961203316676377","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200304060-00002"},{"key":"bibr6-0961203316676377","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02445.x"},{"key":"bibr7-0961203316676377","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2009.30"},{"key":"bibr8-0961203316676377","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.01.015"},{"key":"bibr9-0961203316676377","doi-asserted-by":"publisher","DOI":"10.1186\/ar4111"},{"key":"bibr10-0961203316676377","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.11.007"},{"key":"bibr11-0961203316676377","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06747.x"},{"key":"bibr12-0961203316676377","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2011.05974.x"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203316676377","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0961203316676377","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203316676377","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:17:35Z","timestamp":1777677455000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0961203316676377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,12]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1177\/0961203316676377"],"URL":"https:\/\/doi.org\/10.1177\/0961203316676377","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,12]]}}}