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This compound is effective in a wide range of clinical conditions other than primary immunodeficiency, including autoimmune diseases, inflammatory disorders, infections, organ transplantation, and possibly supportive therapy for cancer. Systemic corticosteroids remain the gold standard treatment for many autoimmune diseases, but their long-term use is associated with complications in diverse organs and systems. Osteoporosis, osteonecrosis, cardiovascular disease, infections, and cancer have been associated with this treatment. Therefore, physicians are occasionally forced to withdraw the treatment with steroids. Biological agents may represent a good alternative, but in addition to being very expensive, these agents may have serious side effects. This review aimed to cover the major advances in the use of IVIg as a steroid-sparing agent in some relevant autoimmune diseases.<\/jats:p>","DOI":"10.1177\/0961203317696589","type":"journal-article","created":{"date-parts":[[2017,3,9]],"date-time":"2017-03-09T23:46:11Z","timestamp":1489103171000},"page":"1015-1022","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Intravenous immunoglobulin: a biological corticosteroid-sparing agent in some autoimmune conditions"],"prefix":"10.1177","volume":"26","author":[{"given":"A","family":"Watad","sequence":"first","affiliation":[{"name":"Department of Medicine \u2018B\u2019, Sheba Medical Center, Israel"},{"name":"Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Israel"},{"name":"Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Amital","sequence":"additional","affiliation":[{"name":"Department of Medicine \u2018B\u2019, Sheba Medical Center, Israel"},{"name":"Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Israel"},{"name":"Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Shoenfeld","sequence":"additional","affiliation":[{"name":"Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Israel"},{"name":"Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,3,9]]},"reference":[{"key":"bibr1-0961203317696589","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.12.007"},{"key":"bibr2-0961203317696589","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2012.12.002"},{"key":"bibr3-0961203317696589","doi-asserted-by":"publisher","DOI":"10.1159\/000368585"},{"key":"bibr4-0961203317696589","doi-asserted-by":"publisher","DOI":"10.1016\/j.rcl.2015.09.009"},{"key":"bibr5-0961203317696589","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61302-7"},{"key":"bibr6-0961203317696589","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2013.08.003"},{"key":"bibr7-0961203317696589","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.11.014"},{"key":"bibr8-0961203317696589","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2196"},{"key":"bibr9-0961203317696589","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2011.04.010"},{"key":"bibr10-0961203317696589","doi-asserted-by":"publisher","DOI":"10.1159\/000069447"},{"key":"bibr11-0961203317696589","doi-asserted-by":"publisher","DOI":"10.1080\/08916930500059633"},{"key":"bibr12-0961203317696589","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-014-8615-z"},{"key":"bibr13-0961203317696589","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-12-4598"},{"key":"bibr14-0961203317696589","unstructured":"Katchan V, David P, Shoenfeld Y. An idiopathic thrombocytopenic purpura with polyneuropathy.\n                      Immunol Res.\n                      Epub ahead of print 18 July 2016. 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Successful treatment with intravenous high-dose immunoglobulin for cardiomyopathy in dermatomyositis complicated with rapid progressive interstitial pneumonia.\n                      Int J Rheum Dis.\n                      Epub ahead of print 7 October 2015. 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Intravenous immunoglobulin: pharmacological properties and use in polyneuropathies.\n                      Expert Opin Drug Metab Toxicol.\n                      Epub ahead of print 22 August 2016. 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