{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:09:39Z","timestamp":1787314179583,"version":"build-2736575974"},"reference-count":49,"publisher":"SAGE Publications","issue":"13","license":[{"start":{"date-parts":[[2017,3,22]],"date-time":"2017-03-22T00:00:00Z","timestamp":1490140800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The objectives of this study were to examine the demographic and clinical features associated with the occurrence of pleuropulmonary manifestations, the predictive factors of their occurrence and their impact on mortality in systemic lupus erythematosus (SLE) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>The association of pleuropulmonary manifestations with demographic and clinical features, the predictive factors of their occurrence and their impact on mortality were examined in GLADEL patients by appropriate univariable and multivariable analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At least one pleuropulmonary manifestation occurred in 421 of the 1480 SLE patients (28.4%), pleurisy being the most frequent (24.0%). Age at SLE onset \u226530 years (OR 1.42; 95% CI 1.10\u20131.83), the presence of lower respiratory tract infection (OR 3.19; 95% CI 2.05\u20134.96), non-ischemic heart disease (OR 3.17; 95% CI 2.41\u20134.18), ischemic heart disease (OR 3.39; 95% CI 2.08\u20135.54), systemic (OR 2.00; 95% CI 1.37\u20132.91), ocular (OR 1.58; 95% CI 1.16\u20132.14) and renal manifestations (OR 1.44; 95% CI 1.09\u20131.83) were associated with pleuropulmonary manifestations, whereas cutaneous manifestations were negatively associated (OR 0.47; 95% CI 0.29\u20130.76). Non-ischemic heart disease (HR 2.24; 95% CI 1.63\u20133.09), SDI scores \u22651 (OR 1.54; 95% CI 1.10\u20132.17) and anti-La antibody positivity (OR 2.51; 95% CI 1.39\u20134.57) independently predicted their subsequent occurrence. Cutaneous manifestations were protective of the subsequent occurrence of pleuropulmonary manifestations (HR 0.62; 95% CI 0.43\u20130.90). Pleuropulmonary manifestations independently contributed a decreased survival (HR: 2.79 95% CI 1.80\u20134.31).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Pleuropulmonary manifestations are frequent in SLE, particularly pleuritis. Older age, respiratory tract infection, cardiac, systemic and renal involvement were associated with them, whereas cutaneous manifestations were negatively associated. Cardiac compromise, SDI scores \u22651 and anti-La positivity at disease onset were predictive of their subsequent occurrence, whereas cutaneous manifestations were protective. They independently contributed to a decreased survival in these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0961203317699284","type":"journal-article","created":{"date-parts":[[2017,3,23]],"date-time":"2017-03-23T01:01:51Z","timestamp":1490230911000},"page":"1368-1377","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":36,"title":["Pleuropulmonary involvement in patients with systemic lupus erythematosus from a Latin American inception cohort (GLADEL)"],"prefix":"10.1177","volume":"26","author":[{"given":"M J","family":"Haye Salinas","sequence":"first","affiliation":[{"name":"Servicio de Reumatolog\u00eda, Hospital Privado, Centro M\u00e9dico de C\u00f3rdoba, C\u00f3rdoba, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Caeiro","sequence":"additional","affiliation":[{"name":"Servicio de Reumatolog\u00eda, Hospital Privado, Centro M\u00e9dico de C\u00f3rdoba, C\u00f3rdoba, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Saurit","sequence":"additional","affiliation":[{"name":"Servicio de Reumatolog\u00eda, Hospital Privado, Centro M\u00e9dico de C\u00f3rdoba, C\u00f3rdoba, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Alvarellos","sequence":"additional","affiliation":[{"name":"Servicio de Reumatolog\u00eda, Hospital Privado, Centro M\u00e9dico de C\u00f3rdoba, C\u00f3rdoba, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Wojdyla","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, GLADEL, Rosario, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H R","family":"Scherbarth","sequence":"additional","affiliation":[{"name":"Servicio de Reumatolog\u00eda, Hospital Interzonal General de Agudos \u201cDr. Oscar Alende\u201d Mar del Plata, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A C","family":"de O e Silva","sequence":"additional","affiliation":[{"name":"Servi\u00e7o da Reumatolog\u00eda, Facultad de de Medicina, Universida de Federal de Goias, Goiania, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J C","family":"Tavares Brenol","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Reumatolog\u00eda, Hospital da Clinicas da Porto Alegre, Universidade Federal do Rio Grande do Sul, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L T","family":"Lavras Costallat","sequence":"additional","affiliation":[{"name":"Divisao de Reumatolog\u00eda, Faculdade de Ciencias Medicas, Universidade Estadual da Campinas, Campinas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O J","family":"Neira","sequence":"additional","affiliation":[{"name":"Secci\u00f3n Reumatolog\u00eda, Hospital del Salvador, Facultad de Medicina, Universidad de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Iglesias Gamarra","sequence":"additional","affiliation":[{"name":"Servicio de Reumatolog\u00eda, Hospital San Juan de Dios, Facultad de Medicina, Universidad Nacional, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"V\u00e1squez","sequence":"additional","affiliation":[{"name":"Servicio de Reumatolog\u00eda, Universidad de Antioquia, Hospital Universitario, Fundaci\u00f3n San Vicente, Medellin, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G A","family":"Reyes Llerena","sequence":"additional","affiliation":[{"name":"Servicio de Reumatolog\u00eda, Centro de Investigaciones M\u00e9dico Quir\u00fargicas (CIMEQ), La Habana, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L A","family":"Barile-Fabris","sequence":"additional","affiliation":[{"name":"Departamento de Reumatologia, Hospital de Especialidades \u201cBernardo Sep\u00falveda\u201d, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano de Seguro Social, M\u00e9xico D.F. M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L H","family":"Silveira","sequence":"additional","affiliation":[{"name":"Departamento de Reumatolog\u00eda, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, M\u00e9xico D.F. 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