{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T23:00:45Z","timestamp":1781305245731,"version":"3.54.1"},"reference-count":12,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2017,3,29]],"date-time":"2017-03-29T00:00:00Z","timestamp":1490745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to investigate the clinical features of acute acalculous cholecystitis (AAC) in patients with systemic lupus erythematosus (SLE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>SLE patients with AAC hospitalized in the Peking Union Medical College Hospital (PUMCH) from January 2001 to September 2015 were retrospectively analyzed. Their medical records were systematically reviewed. The diagnosis of AAC was based on clinical manifestations and confirmed by radiologic findings including a distended gallbladder with thickened wall, pericholecystic fluid and absence of gallstones.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 8411 hospitalized SLE patients in PUMCH, 13 (0.15%) were identified to have SLE-AAC. Eleven (84.6%) of them were female, with a mean age of 30.1\u2009\u00b1\u20098.6 years. AAC was the initial manifestation of SLE in four (30.8%) cases. Eleven (84.6%) patients complained of fever and abdominal pain, four (30.8%) had positive Murphy\u2019s sign and six (46.2%) had elevated liver enzymes. The median SLE Disease Activity Index was 8.0 (range 0\u201320.0) at the time of AAC. Other affected organs in SLE-AAC included kidney (11, 84.6%) and hematologic system (11, 84.6%), followed by mucocutaneous (seven, 53.8%), musculoskeletal (seven, 53.8%) and neuropsychiatric (two, 15.4%) systems. All patients received treatment of glucocorticoids and immunosuppressants but none underwent surgical intervention. During a median follow-up of 28 months (range, 2\u2013320 months), 12 cases (92.4%) responded to treatment with no relapse and one patient (7.6%) died of septic shock.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study suggests that AAC is a relatively uncommon and underestimated gastrointestinal involvement of SLE that is often associated with active disease. For patients with AAC in SLE, treatment with aggressive glucocorticoids could result in a good prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0961203317699288","type":"journal-article","created":{"date-parts":[[2017,3,30]],"date-time":"2017-03-30T01:28:02Z","timestamp":1490837282000},"page":"1101-1105","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Acute acalculous cholecystitis in patients with systemic lupus erythematosus: A unique form of disease flare"],"prefix":"10.1177","volume":"26","author":[{"given":"H","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Clinical Immunology Center, The Ministry of Education Key Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Bian","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Clinical Immunology Center, The Ministry of Education Key Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Clinical Immunology Center, The Ministry of Education Key Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Clinical Immunology Center, The Ministry of Education Key Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Clinical Immunology Center, The Ministry of Education Key Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,3,29]]},"reference":[{"key":"bibr1-0961203317699288","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2005.04.002"},{"key":"bibr2-0961203317699288","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-014-1267-6"},{"key":"bibr3-0961203317699288","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.286.6361.251"},{"key":"bibr4-0961203317699288","doi-asserted-by":"publisher","DOI":"10.1191\/096120398678920154"},{"key":"bibr5-0961203317699288","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/40.6.709"},{"key":"bibr6-0961203317699288","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2002.17.1.61"},{"key":"bibr7-0961203317699288","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-003-0766-6"},{"key":"bibr8-0961203317699288","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-006-0021-x"},{"key":"bibr9-0961203317699288","doi-asserted-by":"publisher","DOI":"10.1177\/0961203308098587"},{"key":"bibr10-0961203317699288","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbr.2014.03.028"},{"key":"bibr11-0961203317699288","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"bibr12-0961203317699288","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199807)41:7<1318::AID-ART24>3.0.CO;2-K"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203317699288","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0961203317699288","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203317699288","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:18:05Z","timestamp":1777677485000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0961203317699288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,29]]},"references-count":12,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1177\/0961203317699288"],"URL":"https:\/\/doi.org\/10.1177\/0961203317699288","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,29]]}}}