{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:04:09Z","timestamp":1777928649942,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2017,6,7]],"date-time":"2017-06-07T00:00:00Z","timestamp":1496793600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:p>Diffuse alveolar haemorrhage (DAH) is a rare life-threatening complication of systemic lupus erythematosus (SLE), associated with high mortality rates. It usually occurs in patients with an established diagnosis of SLE. It has been reported as the initial presentation of SLE in 11\u221220% of cases. It occurs most frequently in females.<\/jats:p>\n                  <jats:p>We describe the case of a child, aged 14 years, with fever, asthenia, haemoptysis, dyspnea, anaemia, increased inflammatory markers, positivity to ANA, nDNA, direct Coombs tests, anticardiolipin antibodies and complement factors consumption. Computed tomography (CTscan) of the chest showed bilateral pulmonary alveolar infiltrates. He also developed renal involvement with nephritis later in the course of the disease. He was started on the treatment approved by the Euro Lupus Protocol for critical patients. After starting Mycophenolate Mofetil the clinical and radiological features were improved as was the survival outcome.<\/jats:p>","DOI":"10.1177\/0961203317713144","type":"journal-article","created":{"date-parts":[[2017,6,8]],"date-time":"2017-06-08T01:46:23Z","timestamp":1496886383000},"page":"507-510","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Diffuse alveolar haemorrage as initial presentation of systemic lupus erythematosus: a case report"],"prefix":"10.1177","volume":"27","author":[{"given":"M E","family":"Cucuzza","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S D","family":"Marino","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Schiavone","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Smilari","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Filosco","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Barone","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,6,7]]},"reference":[{"key":"bibr1-0961203317713144","doi-asserted-by":"publisher","DOI":"10.1177\/0961203315605365"},{"issue":"1","key":"bibr2-0961203317713144","doi-asserted-by":"crossref","first-page":"e19","DOI":"10.1016\/j.lpm.2010.11.004","volume":"40","author":"Torre O","year":"2011","journal-title":"Presse Med"},{"key":"bibr3-0961203317713144","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2003.09.006"},{"key":"bibr4-0961203317713144","doi-asserted-by":"crossref","unstructured":"Imran TF, Yick F, Verma S, Estiverne C, Ogbonnaya-Odor C, Thiruvarudsothy S,\n                      et al\n                      . Lupus nephritis: an update.\n                      Clin Exp Nephrol\n                      2016; 20(1): 1\u201313.","DOI":"10.1007\/s10157-015-1179-y"},{"key":"bibr5-0961203317713144","doi-asserted-by":"publisher","DOI":"10.2174\/157339809787354065"},{"key":"bibr6-0961203317713144","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-9684(15)31553-4"},{"key":"bibr7-0961203317713144","doi-asserted-by":"crossref","unstructured":"Shao WH, Shu DH, Zhen Y, Hilliard B, Priest SO, Cesaroni M,\n                      et al\n                      . Prion-like aggregation of mitochondrial antiviral signaling protein in lupus patients is associated with increased levels of Type I interferon.\n                      Arthritis Rheumatol\n                      2016; 68(11): 269722707.","DOI":"10.1002\/art.39733"},{"key":"bibr8-0961203317713144","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm701"},{"key":"bibr9-0961203317713144","doi-asserted-by":"crossref","unstructured":"Claridge S, Das P, Dorling A, Robson MG. Plasmapheresis as rescue therapy for systemic lupus erthyematosus-associated diffuse alveolar haemorrhage.\n                      BMJ Case Rep\n                      2011; 15.","DOI":"10.1136\/bcr.02.2011.3893"},{"key":"bibr10-0961203317713144","doi-asserted-by":"publisher","DOI":"10.1186\/cc5132"},{"key":"bibr11-0961203317713144","doi-asserted-by":"crossref","unstructured":"Petri M, Orbai AM, Alarc\u0153n, Gordon C, Merrill JT, Fortin PR,\n                      et al\n                      . Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus.\n                      Arthritis Rheum\n                      2012; 64(8): 2677\u20132686.","DOI":"10.1002\/art.34473"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203317713144","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0961203317713144","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203317713144","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:18:20Z","timestamp":1777677500000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0961203317713144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,7]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1177\/0961203317713144"],"URL":"https:\/\/doi.org\/10.1177\/0961203317713144","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,7]]}}}