{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:04:23Z","timestamp":1792008263740,"version":"4.4.0"},"reference-count":40,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2017,8,18]],"date-time":"2017-08-18T00:00:00Z","timestamp":1503014400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The main aim of this study was to investigate the ovarian reserve, menstruation, and lymphocyte subpopulation in systemic lupus erythematosus (SLE) patients of childbearing age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We enrolled 40 SLE patients of childbearing age and 40 age-matched healthy controls. Anti-M\u00fcllerian hormone (AMH) was tested by electrochemiluminescence, and lymphocyte subsets were tested by flow cytometry. Menstruation situation was obtained by interview.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The AMH level of the SLE group was significantly lower than that of the control group ( p\u2009&lt;\u20090.001), which was negatively correlated with erythrocyte sedimentation rate (ESR ( r\u2009=\u2009\u22120.316, p\u2009=\u20090.047)) and disease activity (SLEDAI ( r\u2009=\u2009\u22120.338, p\u2009=\u20090.033)). The AMH concentration of SLE patients with normal menstruation was higher than those with abnormal menstruation ( p\u2009&lt;\u20090.001). The percentages of CD4\n                      <jats:sup>+<\/jats:sup>\n                      T lymphocytes and NK (natural killer) cells in the SLE group were significantly lower than those in the control group ( p\u2009&lt;\u20090.001). However, the percentages of B cells and CD8\n                      <jats:sup>+<\/jats:sup>\n                      T lymphocytes in the SLE group were higher than those in the control group ( p\u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Decreased AMH and high incidence of abnormal menstruation indicated that autoimmunity activities of SLE can impair the ovarian reserve of female patients. Lymphocytes in SLE patients were in a state of disorder.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0961203317726378","type":"journal-article","created":{"date-parts":[[2017,8,18]],"date-time":"2017-08-18T09:38:22Z","timestamp":1503049102000},"page":"445-453","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":29,"title":["Preliminary study on the changes of ovarian reserve, menstruation, and lymphocyte subpopulation in systemic lupus erythematosus (SLE) patients of childbearing age"],"prefix":"10.1177","volume":"27","author":[{"given":"H","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology, Tangdu Hospital of The Fourth Military Medical University, Xi'an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Tangdu Hospital of The 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