{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:09:34Z","timestamp":1787018974896,"version":"build-2736575974"},"reference-count":21,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2017,10,23]],"date-time":"2017-10-23T00:00:00Z","timestamp":1508716800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Our previous research suggested that anti-galectin-3 antibody was highly associated with the development of lupus skin lesions in systemic lupus erythematosus (SLE). In this study we aimed to investigate the involvement of galectin-3 in SLE skin damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study consisted of 49 patients with SLE, 16 with dermatomyositis and 11 with systemic scleroderma and 20 healthy controls. Galectin-3 was examined by ELISA and immunohistochemical staining in serum and skin, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Serum galectin-3 was significantly higher in patients with SLE than in those with dermatomyositis ( P\u2009&lt;\u20090.01), systemic scleroderma ( P\u2009&lt;\u20090.001) and healthy controls ( P\u2009&lt;\u20090.001); however, it was comparable between SLE patients with and without skin lesions ( P\u2009=\u20090.2010 and was not correlated with cutaneous disease activity ( r\u2009=\u2009\u22120.020, P\u2009=\u20090.93) or damage score ( r\u2009=\u2009\u22120.380, P\u2009=\u20090.09). Galectin-3 expression was reduced in epidermis in lesional skin from patients with SLE, dermatomyositis and systemic scleroderma compared to healthy controls ( P\u2009=\u20090.0055), whereas it was comparable among diseases ( P\u2009&gt;\u20090.05). As for subtypes of skin lesions in SLE, galectin-3 expression was lower in chronic cutaneous lupus erythematosus than in acute cutaneous lupus erythematosus ( P\u2009=\u20090.0439).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Serum galectin-3 is unlikely to play a role in the pathogenesis of lupus skin damage, but can be a potential biomarker for the measurement of SLE disease activity. Galectin-3 is greatly reduced in patients with lupus lesions compared with healthy controls, which may contribute to the recruitment of inflammatory cells in the skin.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0961203317736144","type":"journal-article","created":{"date-parts":[[2017,10,23]],"date-time":"2017-10-23T13:38:22Z","timestamp":1508765902000},"page":"621-627","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["The involvement of galectin-3 in skin injury in systemic lupus erythematosus patients"],"prefix":"10.1177","volume":"27","author":[{"given":"Z","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Dermatology, Sun Yat-sen Memorial Hospital, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Sun Yat-sen Memorial Hospital, Guangzhou, China"},{"name":"Institute of Dermatology, Guangzhou Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Sun Yat-sen Memorial Hospital, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Sun Yat-sen Memorial Hospital, Guangzhou, China"},{"name":"Department of Dermatology, Guangzhou Red Cross Hospital, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Sun Yat-sen Memorial Hospital, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Sun Yat-sen Memorial Hospital, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,10,23]]},"reference":[{"key":"bibr1-0961203317736144","first-page":"305","volume":"9","author":"Krzeslak A","year":"2004","journal-title":"Cell Mol Biol Lett"},{"key":"bibr2-0961203317736144","doi-asserted-by":"publisher","DOI":"10.1002\/art.11287"},{"key":"bibr3-0961203317736144","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03941.x"},{"key":"bibr4-0961203317736144","first-page":"S41","volume":"25","author":"Lee YJ","year":"2007","journal-title":"Clin Exp Rheumatol"},{"key":"bibr5-0961203317736144","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-013-2346-8"},{"key":"bibr6-0961203317736144","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)00637-X"},{"key":"bibr7-0961203317736144","doi-asserted-by":"publisher","DOI":"10.1177\/0961203308094361"},{"key":"bibr8-0961203317736144","doi-asserted-by":"publisher","DOI":"10.1002\/art.38891"},{"key":"bibr9-0961203317736144","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"bibr10-0961203317736144","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2005.01.003"},{"key":"bibr11-0961203317736144","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780350606"},{"key":"bibr12-0961203317736144","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2007.00117.x"},{"key":"bibr13-0961203317736144","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502132920706"},{"key":"bibr14-0961203317736144","doi-asserted-by":"crossref","unstructured":"Subcommittee for Scleroderma Criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee. Preliminary criteria for the classification of systemic sclerosis (scleroderma)\n                      Arthritis Rheum\n                      1980; 23: 581\u2013590.","DOI":"10.1002\/art.1780230510"},{"key":"bibr15-0961203317736144","doi-asserted-by":"publisher","DOI":"10.1177\/0961203313513820"},{"key":"bibr16-0961203317736144","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000000781"},{"key":"bibr17-0961203317736144","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-14-136"},{"key":"bibr18-0961203317736144","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.114.218370"},{"key":"bibr19-0961203317736144","doi-asserted-by":"publisher","DOI":"10.1038\/35055582"},{"key":"bibr20-0961203317736144","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.4.1813"},{"key":"bibr21-0961203317736144","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.4.2466"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203317736144","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0961203317736144","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203317736144","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:19:07Z","timestamp":1777677547000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0961203317736144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,23]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1177\/0961203317736144"],"URL":"https:\/\/doi.org\/10.1177\/0961203317736144","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,23]]}}}