{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T02:19:13Z","timestamp":1782785953775,"version":"3.54.5"},"reference-count":26,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T00:00:00Z","timestamp":1513209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The objectives of this paper are to look at the prevalence of neuropsychiatric manifestations and assess their impact on quality of life in North Indian lupus patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study included consecutive patients with systemic lupus erythematosus (SLE) who were older than 18 years and met the SLICC 2012 criteria. A diagnosis of a neuropsychiatric syndrome was made as per ACR 1999 definitions. Manifestations occurring at any point in time after the diagnosis of SLE were considered if a reliable history and medical records were available. Quality of life was assessed by EuroQol-5D questionnaire. Means were compared by student t test for normally distributed data. Comparison of quality of life between groups was performed by the Kruskal\u2013Wallis test and Mann\u2013Whitney U test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This study included 101 patients of SLE with mean (\u00b1SD) age of 32.3\u2009\u00b1\u200910.0 years and a majority ( n\u2009=\u200992) were females. Mean (\u00b1SD) age of diagnosis of SLE was 27.8\u2009\u00b1\u20099.2 years and disease duration (after diagnosis) was 4.6\u2009\u00b1\u20094.5 years. Thirty-three patients had neuropsychiatric manifestations with a total of 42 events. The most common manifestation was headache (10%) followed by anxiety disorder (5%) and peripheral neuropathy (9%). Other NPSLE syndromes observed in the study are seizure (4%), cognitive dysfunction (4%), depression (4%), acute confusional state (2%), autonomic neuropathy (2%), movement disorder (1%), and mononeuritis multiplex (1%). On comparing the groups of NPSLE, nephritis, and neither, there was a significant difference in mobility, self-care, pain, and worry. On post hoc test, there was a significant difference between the NPSLE and neither group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Neuropsychiatric manifestations significantly affect quality of life in North Indian SLE patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0961203317747720","type":"journal-article","created":{"date-parts":[[2017,12,16]],"date-time":"2017-12-16T01:45:15Z","timestamp":1513388715000},"page":"688-693","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Neuropsychiatric manifestations are not uncommon in Indian lupus patients and negatively affect quality of life"],"prefix":"10.1177","volume":"27","author":[{"given":"H","family":"Muhammed","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Goyal","sequence":"additional","affiliation":[{"name":"Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Lal","sequence":"additional","affiliation":[{"name":"Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Dhir","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,12,14]]},"reference":[{"key":"bibr1-0961203317747720","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60128-8"},{"key":"bibr2-0961203317747720","unstructured":"Wallace DJ, Hahn B (eds)\n                      Dubois\u2019 lupus erythematosus\n                      . 7th ed. Philadelphia: Lippincott Williams & Wilkins, 2007."},{"key":"bibr3-0961203317747720","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2005.01.007"},{"key":"bibr4-0961203317747720","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.106351"},{"key":"bibr5-0961203317747720","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-015-0269-8"},{"key":"bibr6-0961203317747720","doi-asserted-by":"publisher","DOI":"10.1002\/art.34473"},{"key":"bibr7-0961203317747720","doi-asserted-by":"crossref","unstructured":"The American College of Rheumatology nomenclature and case definitions for neuropsychiatric lupus syndromes.\n                      Arthritis Rheum\n                      1999; 42: 599\u2013608.","DOI":"10.1002\/1529-0131(199904)42:4<599::AID-ANR2>3.0.CO;2-F"},{"key":"bibr8-0961203317747720","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.2002.00819.x"},{"key":"bibr9-0961203317747720","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051135"},{"key":"bibr10-0961203317747720","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8510(90)90421-9"},{"key":"bibr11-0961203317747720","doi-asserted-by":"publisher","DOI":"10.1002\/art.23566"},{"key":"bibr12-0961203317747720","doi-asserted-by":"publisher","DOI":"10.1177\/0961203306070990"},{"key":"bibr13-0961203317747720","doi-asserted-by":"publisher","DOI":"10.1177\/0961203307085671"},{"key":"bibr14-0961203317747720","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.3.496"},{"key":"bibr15-0961203317747720","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.8.1214"},{"key":"bibr16-0961203317747720","first-page":"985","volume":"30","author":"Sanna G","year":"2003","journal-title":"J Rheumatol"},{"key":"bibr17-0961203317747720","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000058904.94330.A7"},{"key":"bibr18-0961203317747720","first-page":"766","volume":"28","author":"Mok CC","year":"2001","journal-title":"J Rheumatol"},{"key":"bibr19-0961203317747720","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh384"},{"key":"bibr20-0961203317747720","doi-asserted-by":"publisher","DOI":"10.5402\/2012\/989218"},{"key":"bibr21-0961203317747720","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-008-0921-1"},{"key":"bibr22-0961203317747720","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780210103"},{"key":"bibr23-0961203317747720","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh624"},{"key":"bibr24-0961203317747720","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2011.04.001"},{"key":"bibr25-0961203317747720","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/93.3.169"},{"key":"bibr26-0961203317747720","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.138792"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203317747720","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0961203317747720","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203317747720","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:19:16Z","timestamp":1777677556000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0961203317747720"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,14]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1177\/0961203317747720"],"URL":"https:\/\/doi.org\/10.1177\/0961203317747720","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,14]]}}}