{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T19:35:22Z","timestamp":1788118522398,"version":"build-2803163510"},"reference-count":34,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2018,1,4]],"date-time":"2018-01-04T00:00:00Z","timestamp":1515024000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Hypertension (HTN) is prevalent in patients with systemic lupus erythematosus (SLE) and causes early cardiovascular aging and progression of renal and cardiac disease. The aim of this longitudinal retrospective study was to evaluate the prevalence of HTN, the follow-up blood pressure trends, and risk factors for HTN in a population-based cohort with childhood-onset SLE (cSLE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Demographic and clinical data of consecutive visits from the baseline to the last visit were extracted from electronic medical records of patients with cSLE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 110 patients with cSLE were identified with a median follow-up duration of 29.5 months; 19% had lupus nephritis (LN) at diagnosis. Further, 29% and 23% had HTN and preHTN at the baseline visit. Compared to those without HTN, patients with HTN had higher disease activity, obesity, more frequent LN, and lower eGFR. In multivariate analysis, the presence of LN, obesity, and high extra-renal disease activity were independent predictors of HTN at baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>While HTN is a known feature of LN, HTN is common and persistent in cSLE without LN, with about one-third of patients having uncontrolled elevated blood pressure almost three years after the onset of lupus. In addition to LN, obesity and high overall disease activity were independent predictors of HTN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0961203317751061","type":"journal-article","created":{"date-parts":[[2018,1,5]],"date-time":"2018-01-05T00:23:27Z","timestamp":1515111807000},"page":"657-664","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Blood pressure control over time in childhood-onset systemic lupus erythematous"],"prefix":"10.1177","volume":"27","author":[{"given":"P O","family":"Avar Aydin","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Cincinnati Children's Hospital, Cincinnati, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Shan","sequence":"additional","affiliation":[{"name":"Peking Union Medical College Hospital, Peking, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H I","family":"Brunner","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Cincinnati Children's Hospital, Cincinnati, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M M","family":"Mitsnefes","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Cincinnati Children's Hospital, Cincinnati, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,1,4]]},"reference":[{"key":"bibr1-0961203317751061","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21757"},{"key":"bibr2-0961203317751061","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2009.12.012"},{"key":"bibr3-0961203317751061","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000317"},{"key":"bibr4-0961203317751061","doi-asserted-by":"publisher","DOI":"10.1002\/art.21955"},{"key":"bibr5-0961203317751061","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20122"},{"key":"bibr6-0961203317751061","doi-asserted-by":"publisher","DOI":"10.1191\/0961203305lu2238oa"},{"key":"bibr7-0961203317751061","doi-asserted-by":"publisher","DOI":"10.1177\/0003319715613917"},{"key":"bibr8-0961203317751061","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.059311"},{"key":"bibr9-0961203317751061","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.303697"},{"key":"bibr10-0961203317751061","doi-asserted-by":"publisher","DOI":"10.1177\/1753944716637807"},{"key":"bibr11-0961203317751061","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.190009"},{"key":"bibr12-0961203317751061","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2014.05.001"},{"key":"bibr13-0961203317751061","first-page":"493","volume":"30","author":"Al-Herz A","year":"2003","journal-title":"J Rheumatol"},{"key":"bibr14-0961203317751061","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"bibr15-0961203317751061","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00443.x"},{"key":"bibr16-0961203317751061","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1984.75"},{"key":"bibr17-0961203317751061","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008030287"},{"key":"bibr18-0961203317751061","first-page":"288","volume":"29","author":"Gladman DD","year":"2002","journal-title":"J Rheumatol"},{"key":"bibr19-0961203317751061","doi-asserted-by":"publisher","DOI":"10.3345\/kjp.2011.54.11.463"},{"issue":"2","key":"bibr20-0961203317751061","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1542\/peds.114.2.S2.555","volume":"114","author":"National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents","year":"2004","journal-title":"Pediatrics"},{"key":"bibr21-0961203317751061","first-page":"1","volume":"11","author":"Kuczmarski RJ","year":"2002","journal-title":"Vital Health Stat"},{"issue":"5","key":"bibr22-0961203317751061","first-page":"S213","volume":"128","author":"Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents; 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