{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:04:42Z","timestamp":1777928682371,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T00:00:00Z","timestamp":1515542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100005918","name":"Christian Medical College, Vellore","doi-asserted-by":"publisher","award":["Fluid research grant"],"award-info":[{"award-number":["Fluid research grant"]}],"id":[{"id":"10.13039\/501100005918","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Deflazacort (DFZ), an oxazoline derivative of prednisolone (PDN), has a dose equivalence of 1.2:1 (mg) to PDN. No study to date has compared adverse effects and efficacy of high doses of DFZ as against high-dose PDN in systemic lupus erythematosus (SLE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To compare adverse effects of high dose DFZ and PDN in SLE patients, especially in terms of cushingoid features and gain in body weight, 3 and 6 months after initiation of these agents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In both the steroid arms, the following outcome parameters were assessed at 3 and 6 months: (a) cushingoid features by Cushing's Severity Index (CSI) (b) hirsutism by modified Ferriman Gallwey score (c) weight gain by difference (\u0394, delta) of weight (in kilograms).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients on PDN had 1.6\u2009kg (3.2%) and 2\u2009kg (5.1%) higher median weight gain as compared to those on DFZ at 3 and 6 months respectively (\u2009 p\u2009=\u20090.012 and 0.001). PDN caused 10% and 22.2% higher increment in median hirsutism scores as compared to DFZ at 3 months and 6 months follow-up, respectively (\u2009 p\u2009=\u20090.004 and 0.002). PDN caused 100% higher increase in median CSI scores than DFZ at 6 months (\u2009 p\u2009=\u20090.03). There was no significant difference by generalized estimation equation between the groups with respect to changes in SLEDAI, renal SLEDAI, anti-dsDNA titres and C3\/C4 levels. There were two serious infections (requiring hospitalization\/intravenous antibiotics) in the PDN group, while none in the DFZ group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Comparable intake and tapering of high dose DFZ and PDN in active SLE revealed 2-fold less weight gain, 2.5-fold less hirsutism and 1.5-fold lower cushingoid severity index as well as lower glycaemic elevation in the DFZ group as compared to PDN group. Both had similar efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0961203317751854","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T02:06:59Z","timestamp":1515722819000},"page":"890-898","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Head to head comparison of adverse effects and efficacy between high dose deflazacort and high dose prednisolone in systemic lupus erythematosus: a prospective cohort study"],"prefix":"10.1177","volume":"27","author":[{"given":"A","family":"Ganapati","sequence":"first","affiliation":[{"name":"Department of Clinical Immunology and Rheumatology, Christian Medical College, Vellore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Ravindran","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Rheumatology, Christian Medical College, Vellore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"David","sequence":"additional","affiliation":[{"name":"Department of Medicine II, Christian Medical College, Vellore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Christian Medical College, Vellore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Jeyaseelan","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Christian Medical College, Vellore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Jeyaseelan","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Christian Medical College, Vellore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Danda","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and 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