{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:03:40Z","timestamp":1790949820112,"version":"4.1.0"},"reference-count":16,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2018,5,17]],"date-time":"2018-05-17T00:00:00Z","timestamp":1526515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000960","name":"American College of Rheumatology Research and Education Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000960","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008741","name":"European League Against Rheumatism","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008741","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The European League Against Rheumatism and the American College of Rheumatology jointly embarked on a new classification criteria for systemic lupus erythematosus (SLE) project. Its first phase involved generation of a broad set of items potentially useful for classification of SLE. This study was undertaken to add the patient perspective to an expert Delphi approach and an early patient cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A national cross-sectional study was conducted. A self-report questionnaire was published in the \u201cSchmetterling\u201d (Butterfly), the quarterly journal of the German SLE patient association. Individuals with SLE were asked to anonymously complete the questionnaire, which asked for demographic details, organ manifestations, autoantibodies and symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 339 completed questionnaires out of 2498 were returned, a response rate of 13.6%; 83.2% reported they were ANA positive and 81.7% reported joint, 66.1% skin and 33.0% renal involvement. For the time before and in the first year after their SLE diagnosis, the majority reported fatigue (89.4%), joint pain (86.7%), photosensitivity (79.4%) and myalgia (76.1%). Of interest, more than half of the patients reported fever as an early symptom (53.7%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>For a Caucasian European SLE patient population, the overall characteristics suggest meaningful representation. While many symptoms were reported as expected, the high percentage of patients reporting fever and the significant number of patients with unexpected gastrointestinal complaints are of particular interest. These data add to the information on early SLE symptoms informing the development process of new SLE classification criteria.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0961203318776093","type":"journal-article","created":{"date-parts":[[2018,5,17]],"date-time":"2018-05-17T10:03:36Z","timestamp":1526551416000},"page":"1431-1436","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":72,"title":["Early symptoms of systemic lupus erythematosus (SLE) recalled by 339 SLE patients"],"prefix":"10.1177","volume":"27","author":[{"given":"N","family":"Leuchten","sequence":"first","affiliation":[{"name":"Department of Medicine III, University Medical Center Carl Gustav Carus, Technische Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Milke","sequence":"additional","affiliation":[{"name":"Department of Medicine III, University Medical Center Carl Gustav Carus, Technische Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Winkler-Rohlfing","sequence":"additional","affiliation":[{"name":"Lupus Erythematodes Selbsthilfegemeinschaft e.V., Wuppertal, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Daikh","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California, San Francisco, USA"},{"name":"Department of Veterans Affairs Medical Center, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"D\u00f6rner","sequence":"additional","affiliation":[{"name":"Department of Medicine, Rheumatology, and Clinical Immunology, Charit\u00e9 Universit\u00e4tsmedizin and Deutsches Rheuma-Forschungszentrum, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S R","family":"Johnson","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Toronto Western Hospital, University of Toronto, Toronto, Canada"},{"name":"Mount Sinai Hospital, Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Aringer","sequence":"additional","affiliation":[{"name":"Department of Medicine III, University Medical Center Carl Gustav Carus, Technische Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,5,17]]},"reference":[{"key":"bibr1-0961203318776093","doi-asserted-by":"publisher","DOI":"10.1002\/art.34473"},{"key":"bibr2-0961203318776093","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"bibr3-0961203318776093","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780251101"},{"key":"bibr4-0961203318776093","doi-asserted-by":"publisher","DOI":"10.1177\/0961203313512883"},{"key":"bibr5-0961203318776093","unstructured":"Hoyer BF, Schmajuk G, Aringer M, et\u00a0al. Multi-center Delphi exercise reveals important key items in classifying SLE.\n                      2015 ACR\/ARHP Annual Meeting Abstract Supplement\n                      .\n                      Arthritis Rheum\n                      2015, #746 (abstract)."},{"key":"bibr6-0961203318776093","unstructured":"Mosca M, Touma Z, Costenbader KH, et\u00a0al. How do patients with newly diagnosed SLE present? a multicenter cohort analysis to inform the development of new classification criteria for SLE.\n                      2015 ACR\/ARHP Annual Meeting Abstract Supplement\n                      .\n                      Arthritis Rheum\n                      2015, #2948 (abstract)."},{"key":"bibr7-0961203318776093","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.135129"},{"key":"bibr8-0961203318776093","doi-asserted-by":"publisher","DOI":"10.1177\/0961203310377090"},{"key":"bibr9-0961203318776093","doi-asserted-by":"publisher","DOI":"10.1002\/art.24165"},{"key":"bibr10-0961203318776093","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199303000-00005"},{"key":"bibr11-0961203318776093","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000267"},{"key":"bibr12-0961203318776093","doi-asserted-by":"crossref","unstructured":"Leuchten N, Hoyer A, Brinks R, et\u00a0al. Performance of antinuclear antibodies for classifying systemic lupus erythematosus: a systematic literature review and meta-regression of diagnostic data.\n                      Arthritis Care Res (Hoboken)\n                      2018; 70: 428\u2013438.","DOI":"10.1002\/acr.23292"},{"key":"bibr13-0961203318776093","doi-asserted-by":"crossref","unstructured":"Touma Z, Costenbader KH, Johnson SR, et\u00a0al. Do patients with SLE at onset differ from mimickers? a comparison of clinical and serological manifestations in a multicenter cohort to inform the development of new classification criteria for SLE.\n                      EULAR Congress 2016\n                      .\n                      Ann Rheum Dis\n                      2016, p.558 (abstract).","DOI":"10.1136\/annrheumdis-2016-eular.4437"},{"key":"bibr14-0961203318776093","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000091181.93122.55"},{"key":"bibr15-0961203318776093","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2017.01.010"},{"key":"bibr16-0961203318776093","doi-asserted-by":"publisher","DOI":"10.1177\/0961203309103870"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203318776093","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0961203318776093","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203318776093","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:19:44Z","timestamp":1777677584000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0961203318776093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,17]]},"references-count":16,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1177\/0961203318776093"],"URL":"https:\/\/doi.org\/10.1177\/0961203318776093","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,17]]}}}