{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:19:34Z","timestamp":1791231574978,"version":"4.1.0"},"reference-count":46,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T00:00:00Z","timestamp":1532044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["1K12HD085816"],"award-info":[{"award-number":["1K12HD085816"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Preterm delivery for preeclampsia or placental insufficiency (PREPI) is a clinical criterion for antiphospholipid syndrome (APS), but no prior prospective studies have used the international classification criteria for APS. Our objective is to determine the proportion of women with PREPI who test positive for aPL using international criteria for antiphospholipid antibody (aPL) assays.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a prospective, case-control study of 148 women delivered\u2009&lt;\u200936 weeks because of PREPI compared to 148 controls. PREPI cases delivered\u2009&lt;\u200936 weeks were compared to matched controls. Cases and controls were tested for aPL. Demographic variables were compared with chi-squared and Wilcoxon-rank-sum statistics. Rates of\u2009+\u2009aPL were compared using adjusted odds ratios (aORs) for maternal body mass index (BMI) and Caucasian race. Positive aPL (+aPL) was defined as lupus anticoagulant (LA), anticardiolipin (aCL) immunoglobulin G (IgG) (GPL) or immunoglobulin M (IgM) (MPL)\u2009\u2265\u200940, or anti-\u03b22-glycoprotein I (a\u03b22GPI) IgG (SGU) or IgM (SMU)\u2009\u2265\u200940.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Controls were more likely to be Caucasian (87% vs 70%, p\u2009=\u20090.006) and had lower BMIs (BMI 26 vs 33, p\u2009&lt;\u20090.001). Positive aPL were found more commonly in cases than controls (11.5% vs 1.4%, aOR 8.9 (95% CI 1.9\u201341.4)). In\u2009+\u2009aPL cases, 76% had\u2009+\u2009LA, 41% had\u2009+\u2009aCL, and 24% had\u2009+\u2009a\u03b22GPI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Women requiring early delivery for PREPI are more likely to have aPL (and thus APS) than controls. This is the first prospective study using both obstetric definitions and laboratory criteria in accordance with APS international criteria.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0961203318787035","type":"journal-article","created":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T08:40:21Z","timestamp":1532076021000},"page":"1903-1910","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":42,"title":["Antiphospholipid antibodies in women with severe preeclampsia and placental insufficiency: a case-control study"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7431-3451","authenticated-orcid":false,"given":"K J","family":"Gibbins","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A E","family":"Tebo","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Utah School of Medicine, Salt Lake City; UT ARUP Laboratories, Salt Lake City, UT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S K","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D W","family":"Branch","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Intermountain Healthcare Department of Maternal Fetal Medicine, Salt Lake City, UT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,7,20]]},"reference":[{"key":"bibr1-0961203318787035","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.01753.x"},{"key":"bibr2-0961203318787035","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2008.11.001"},{"key":"bibr3-0961203318787035","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2009.10.005"},{"key":"bibr4-0961203318787035","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.03747.x"},{"key":"bibr5-0961203318787035","first-page":"1108","volume":"78","author":"Polzin WJ","year":"1991","journal-title":"Obstet Gynecol"},{"key":"bibr6-0961203318787035","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181fe02ec"},{"key":"bibr7-0961203318787035","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2011.02.006"},{"key":"bibr8-0961203318787035","first-page":"541","volume":"73","author":"Branch DW","year":"1989","journal-title":"Obstet Gynecol"},{"key":"bibr9-0961203318787035","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(95)00247-O"},{"key":"bibr10-0961203318787035","first-page":"294","volume":"102","author":"Lee R","year":"2003","journal-title":"Obstet Gynecol"},{"key":"bibr11-0961203318787035","first-page":"29","volume":"97","author":"Dreyfus M","year":"2001","journal-title":"Obstet Gynecol"},{"key":"bibr12-0961203318787035","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1996.tb00143.x"},{"key":"bibr13-0961203318787035","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.07.032"},{"key":"bibr14-0961203318787035","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000188979.74172.4d"},{"key":"bibr15-0961203318787035","first-page":"37","volume":"73","author":"Faden D","year":"1997","journal-title":"Obstet Gynecol"},{"key":"bibr16-0961203318787035","doi-asserted-by":"publisher","DOI":"10.1080\/01443610120113247"},{"key":"bibr17-0961203318787035","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(91)90348-U"},{"key":"bibr18-0961203318787035","first-page":"45","volume":"96","author":"Kupferminc MJ","year":"2000","journal-title":"Obstet Gynecol"},{"key":"bibr19-0961203318787035","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1993.tb15105.x"},{"issue":"5","key":"bibr20-0961203318787035","first-page":"753","volume":"97","author":"Alfirevic Z","year":"2001","journal-title":"Obstet Gynecol"},{"key":"bibr21-0961203318787035","doi-asserted-by":"publisher","DOI":"10.1159\/000009930"},{"key":"bibr22-0961203318787035","first-page":"197","volume":"29","author":"Mello G","year":"1999","journal-title":"Haemostasis"},{"key":"bibr23-0961203318787035","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(91)90222-D"},{"key":"bibr24-0961203318787035","first-page":"105","volume":"85","author":"Moodley J","year":"1995","journal-title":"S Afr Med J"},{"key":"bibr25-0961203318787035","doi-asserted-by":"publisher","DOI":"10.3109\/00016349209006228"},{"key":"bibr26-0961203318787035","first-page":"126","volume":"48","author":"Wharfe G","year":"1999","journal-title":"West Indian Med J"},{"key":"bibr27-0961203318787035","doi-asserted-by":"publisher","DOI":"10.1093\/HUMREP\/11.3.509"},{"key":"bibr28-0961203318787035","doi-asserted-by":"publisher","DOI":"10.1177\/096120339500400506"},{"key":"bibr29-0961203318787035","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1993.tb15319.x"},{"key":"bibr30-0961203318787035","first-page":"97","volume":"70","author":"Uncu G","year":"1996","journal-title":"Obstet Gynecol"},{"key":"bibr31-0961203318787035","doi-asserted-by":"publisher","DOI":"10.1016\/S0188-4409(02)00367-3"},{"key":"bibr32-0961203318787035","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70608-3"},{"key":"bibr33-0961203318787035","doi-asserted-by":"publisher","DOI":"10.1159\/000263951"},{"key":"bibr34-0961203318787035","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.02.003"},{"key":"bibr35-0961203318787035","doi-asserted-by":"crossref","unstructured":"American College of Obstetricians and Gynecologists. 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