{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T17:37:32Z","timestamp":1783705052301,"version":"3.55.0"},"reference-count":47,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T00:00:00Z","timestamp":1532044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Bio & Medical Technology Development Program of the NRF funded by the Korean government","award":["MSIT(NRF-2017M3A9B4050335)"],"award-info":[{"award-number":["MSIT(NRF-2017M3A9B4050335)"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aims to identify the factors associated with the development and mortality of pulmonary hypertension (PH) in systemic lupus erythematosus (SLE) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a prospective study of SLE patients in a single tertiary center. PH was defined as a systolic pulmonary arterial pressure \u226530\u2009mmHg on transthoracic echocardiography. We assessed potential associated factors contributing to the development and mortality of PH in SLE patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 1110 patients with SLE, 48 patients were identified to have PH. Multivariable analysis indicated that pleuritis or pericarditis (odds ratio (OR)\u2009=\u20094.62), anti-RNP antibody (OR\u2009=\u20092.42), interstitial lung disease (ILD) (OR\u2009=\u20098.34) and cerebro-cardiovascular disease (OR\u2009=\u200913.37) were independently associated with the development of PH in SLE. Subgroup analysis among patients with PH demonstrated that there were no statistically significant factors associated with PH mortality in SLE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The prevalence of PH was 4.3% in our cohort. There were significant associations with pleuritis or pericarditis, anti-RNP antibody, ILD, and cerebro-cardiovascular disease in SLE, which may contribute to the development of PH. However, there were no statistically significant factors associated with PH mortality in SLE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0961203318788163","type":"journal-article","created":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T08:40:21Z","timestamp":1532076021000},"page":"1769-1777","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Factors associated with development and mortality of pulmonary hypertension in systemic lupus erythematosus patients"],"prefix":"10.1177","volume":"27","author":[{"given":"J S","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y B","family":"Joo","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, St Vincent's Hospital, Catholic University of Korea, Suwon, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Won","sequence":"additional","affiliation":[{"name":"Clinical Research Center for Rheumatoid Arthritis, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Lee","sequence":"additional","affiliation":[{"name":"Clinical Research Center for Rheumatoid Arthritis, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hanyang University Hospital, Seoul, Republic of 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