{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T22:31:02Z","timestamp":1783636262620,"version":"3.55.0"},"reference-count":31,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T00:00:00Z","timestamp":1546560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of this paper is to analyse whether digital capillary morphology, analysed by nailfold videocapillaroscopy (NVC), and the number of circulating CD3\u2009+\u2009CD31\u2009+\u2009CXCR4\u2009+\u2009lymphocytes (angiogenic T cells) could be markers of endothelial dysfunction (ED) in systemic lupus erythematosus (SLE) without cardiovascular disease (CVD) and CV risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Nineteen consecutive SLE patients, according to Systemic Lupus International Collaborating Clinics Classification Criteria, with a disease duration less than five years, low disease activity, without CVD and CV risk factors (diabetes, chronic renal disease, uncontrolled systemic arterial hypertension, smoking, hypercholesterolemia, obesity), statin or beta-blocker use were enrolled. Each patient and sex- and age-matched healthy control (HC) underwent Doppler echocardiogram, an endothelial function study by peripheral arterial tonometry technique, NVC and peripheral blood immunophenotyping.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>SLE ED+ more frequently showed NVC abnormalities compared with HCs ( p\u2009&lt;\u20090.0001) in terms of minor alterations ( p\u2009=\u20090.017), lower capillary numbers ( p\u2009=\u20090.0035) and major alterations. SLE ED\u2009+\u2009showed a higher rate of CD3\u2009+\u2009CD31\u2009+\u2009CXCR4\u2009+\u2009lymphocytes compared with SLE ED\u2013 and with HCs. NVC\u2009+\u2009SLE showed a significantly reduced rate of total CD3\u2009+\u2009cells, but a higher rate and absolute number of CD3\u2009+\u2009CD31\u2009+\u2009CXCR4\u2009+\u2009, compared with NVC\u2013 SLE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>NVC alterations are frequent in SLE without any CV risk factors and CVD. They are associated with ED and increased circulating CD3\u2009+\u2009CD31\u2009+\u2009CXCR4\u2009+\u2009lymphocytes. These findings demonstrate a clear microvascular perturbation in patients with short disease duration, low disease activity and no CV risk factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0961203318821161","type":"journal-article","created":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T08:43:30Z","timestamp":1546591410000},"page":"210-216","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Relationship between endothelial dysfunction, videocapillaroscopy and circulating CD3+CD31+CXCR4+ lymphocytes in systemic lupus erythematosus without cardiovascular risk factors"],"prefix":"10.1177","volume":"28","author":[{"given":"I","family":"Cavazzana","sequence":"first","affiliation":[{"name":"Rheumatology and Clinical Immunology Unit, ASST-Spedali Civili of Brescia, Brescia, 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