{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:06:16Z","timestamp":1777928776196,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T00:00:00Z","timestamp":1560816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study was to: (a) screen a large group of unselected patients with juvenile systemic lupus erythematosus for anti-aquaporin 4 antibodies (AQP4-Ab); (b) identify clinical and laboratory predictors of the presence of AQP4-Ab positivity in juvenile systemic lupus erythematosus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sera from 90 patients with juvenile systemic lupus erythematosus were tested for the presence of AQP4-Ab using a cell-based assay. Demographics, clinical and immunological features, treatment received were summarized. Fisher\u2019s exact test was used to identify clinical predictors of positivity for AQP4-Ab.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Five of 90 (5.5%) patients tested positive for AQP4-Ab, all of which had neurological involvement, mainly transverse myelitis and optic neuritis. AQP4-Ab-positive patients were more likely to have neurological symptoms ( P\u2009=\u20090.002), less likely to experience dermatological manifestations ( P\u2009=\u20090.045), and less likely to have detectable anti-dsDNA antibodies ( P\u2009=\u20090.022). These patients were also more likely to have received anti-epileptic ( P\u2009=\u20090.023) and anti-coagulant ( P\u2009=\u20090.007) drugs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The findings of this study indicate that some patients with juvenile systemic lupus erythematosus develop antibodies against aquaporin-4 and may be at risk of developing a neurological clinical phenotype. We suggest that all juvenile systemic lupus erythematosus patients should be systematically screened for the presence of AQP4-Ab and this may help identify a high risk for neurological involvement in juvenile systemic lupus erythematosus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0961203319855125","type":"journal-article","created":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T02:06:01Z","timestamp":1560909961000},"page":"1243-1249","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Aquaporin-4 IgG antibody-related disorders in patients with juvenile systemic lupus erythematosus"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9615-460X","authenticated-orcid":false,"given":"E","family":"Moraitis","sequence":"first","affiliation":[{"name":"Infection, Inflammation and Rheumatology Section, UCL GOS Institute of Child Health, London, UK"},{"name":"Rheumatology Unit, Great Ormond Street Hospital NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Stathopoulos","sequence":"additional","affiliation":[{"name":"Medical School, University College of London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Hong","sequence":"additional","affiliation":[{"name":"Infection, Inflammation and Rheumatology Section, UCL GOS Institute of Child Health, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Al-Obaidi","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Great Ormond Street Hospital NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Mankad","sequence":"additional","affiliation":[{"name":"Neuroradiology Department, Great Ormond Street Hospital NHS Foundation Trust, London, UK"},{"name":"UCL GOS Institute of Child Health, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Hacohen","sequence":"additional","affiliation":[{"name":"Neurology Department, Great Ormond Street Hospital NHS Foundation Trust, London, UK"},{"name":"Department of Neuroinflammation, UCL Institute of Neurology, London, UK"},{"name":"Department of Clinical Neuroscience, UCL GOS Institute of Child Health, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Sen","sequence":"additional","affiliation":[{"name":"Arthritis Research UK, Centre for Adolescent Rheumatology at UCL, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Hemingway","sequence":"additional","affiliation":[{"name":"Neurology Department, Great Ormond Street Hospital NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Eleftheriou","sequence":"additional","affiliation":[{"name":"Infection, Inflammation and Rheumatology Section, UCL GOS Institute of Child Health, London, UK"},{"name":"Rheumatology Unit, Great Ormond Street Hospital NHS Foundation Trust, London, UK"},{"name":"Arthritis Research UK, Centre for Adolescent Rheumatology at UCL, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,6,18]]},"reference":[{"key":"bibr1-0961203319855125","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-63432-0.00021-9"},{"key":"bibr2-0961203319855125","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2017.09.013"},{"key":"bibr3-0961203319855125","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3468"},{"key":"bibr4-0961203319855125","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2015.10.007"},{"key":"bibr5-0961203319855125","doi-asserted-by":"crossref","unstructured":"Asgari N, Jarius S, Laustrup H,\n                      et\u00a0al\n                      . Aquaporin-4-autoimmunity in patients with systemic lupus erythematosus: a predominantly population-based study.\n                      Mult Scler\n                      2018; 24(3): 331\u2013339. 1352458517699791.","DOI":"10.1177\/1352458517699791"},{"key":"bibr6-0961203319855125","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000314832.24682.c6"},{"key":"bibr7-0961203319855125","doi-asserted-by":"publisher","DOI":"10.1177\/0961203316644333"},{"key":"bibr8-0961203319855125","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"bibr9-0961203319855125","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318248dec1"},{"key":"bibr10-0961203319855125","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001729"},{"key":"bibr11-0961203319855125","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31825644ff"},{"key":"bibr12-0961203319855125","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2017.1269168"}],"updated-by":[{"DOI":"10.1177\/0961203320911356","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T00:00:00Z","timestamp":1583712000000}}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203319855125","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0961203319855125","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203319855125","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:21:02Z","timestamp":1777677662000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0961203319855125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,18]]},"references-count":12,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1177\/0961203319855125"],"URL":"https:\/\/doi.org\/10.1177\/0961203319855125","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,18]]}}}