{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:59:48Z","timestamp":1792803588241,"version":"4.5.0"},"reference-count":100,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T00:00:00Z","timestamp":1560902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:p>Sj\u00f6gren syndrome is a systemic autoimmune disease that principally affects women between the fourth and sixth decades of life who present with sicca symptomatology caused by dryness of the main mucosal surfaces. The clinical spectrum of Sj\u00f6gren syndrome extends from dryness to systemic involvement. Since 1978, Sj\u00f6gren syndrome has been closely associated with an enhanced risk of lymphoma, one of the most severe complications a patient may develop. Primary Sj\u00f6gren syndrome patients have a 10\u201344-fold greater risk of lymphoma than healthy individuals, higher than that reported for systemic lupus erythematosus and rheumatoid arthritis. The close link between lymphoma and Sj\u00f6gren syndrome is clearly exemplified by the very specific type of lymphoma arising in Sj\u00f6gren syndrome patients, mainly low-grade B-cell lymphomas (predominantly a marginal zone histological type) with primary extranodal involvement of the major salivary glands (overwhelmingly parotid), with a primordial role of cryoglobulinemic-related markers (both clinical and immunological). The most recent studies support a higher number of risk factors detected in an individual leads to a higher lymphoma risk. A close follow-up of high-risk groups with longitudinal assessments of all known risk factors, including cryoglobulin-related markers and EULAR Sj\u00f6gren's syndrome disease activity index measurement in particular, is mandatory.<\/jats:p>","DOI":"10.1177\/0961203319857132","type":"journal-article","created":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T09:40:26Z","timestamp":1560937226000},"page":"923-936","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":91,"title":["Prognostic markers of lymphoma development in primary Sj\u00f6gren syndrome"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0075-4454","authenticated-orcid":false,"given":"S","family":"Retamozo","sequence":"first","affiliation":[{"name":"Instituto de Investigaciones en Ciencias de la Salud (INICSA), Universidad Nacional de C\u00f3rdoba (UNC), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), C\u00f3rdoba, Argentina"},{"name":"Instituto Universitario de Ciencias Biom\u00e9dicas de C\u00f3rdoba (IUCBC), C\u00f3rdoba, Argentina"},{"name":"Laboratory of Autoimmune Diseases Josep Font, IDIBAPS-CELLEX, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Brito-Zer\u00f3n","sequence":"additional","affiliation":[{"name":"Laboratory of Autoimmune Diseases Josep Font, IDIBAPS-CELLEX, Barcelona, Spain"},{"name":"Department of Medicine, Hospital CIMA-Sanitas, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Ramos-Casals","sequence":"additional","affiliation":[{"name":"Laboratory of Autoimmune Diseases Josep Font, IDIBAPS-CELLEX, Barcelona, Spain"},{"name":"Department of Autoimmune Diseases, ICMiD, Barcelona, Spain"},{"name":"Department of Medicine, University of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,6,19]]},"reference":[{"key":"bibr1-0961203319857132","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.47"},{"key":"bibr2-0961203319857132","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e3821"},{"key":"bibr3-0961203319857132","doi-asserted-by":"publisher","DOI":"10.1002\/art.20176"},{"key":"bibr4-0961203319857132","doi-asserted-by":"publisher","DOI":"10.1002\/art.21675"},{"key":"bibr5-0961203319857132","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-018-3515-2"},{"key":"bibr6-0961203319857132","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206418"},{"key":"bibr7-0961203319857132","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.20.2337"},{"key":"bibr8-0961203319857132","first-page":"477","volume-title":"Sj\u00f6gren\u2019s Syndrome. 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