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The link between systemic lupus erythematosus (SLE) and hypertrophic pachymeningitis (HP) is extremely rare, with only six other cases reported in the literature. We, however, report the first case of SLE pachymeningitis presenting with multiple cranial nerve palsies. The patient showed good response to steroids and cyclophosphamide therapy. One should maintain a high index of suspicion to make the diagnosis in patients with SLE presenting with neurological dysfunction. Prompt therapy prevents long-term neurological sequelae.<\/jats:p>","DOI":"10.1177\/0961203319862867","type":"journal-article","created":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T06:20:24Z","timestamp":1563862824000},"page":"1154-1157","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["SLE pachymeningitis and multiple cranial nerve palsies: a case report and review of the literature"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4152-0868","authenticated-orcid":false,"given":"T J","family":"John","sequence":"first","affiliation":[{"name":"Division of Cardiology, Stellenbosch University & Tygerberg Academic Hospital, Cape Town, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"John","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, Department of Medicine, Stellenbosch University & Tygerberg Academic Hospital, Cape Town, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"du Plessis","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Stellenbosch University & Tygerberg Academic Hospital, Cape Town, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Manie","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Stellenbosch University & Tygerberg Academic Hospital, Cape Town, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,7,23]]},"reference":[{"key":"bibr1-0961203319862867","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.160457"},{"key":"bibr2-0961203319862867","doi-asserted-by":"publisher","DOI":"10.4081\/reumatismo.2013.248"},{"key":"bibr3-0961203319862867","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000113748.53023.B7"},{"key":"bibr4-0961203319862867","first-page":"103","volume":"1","author":"Larbi T","year":"2015","journal-title":"Lupus (Los Angel)"},{"key":"bibr5-0961203319862867","doi-asserted-by":"publisher","DOI":"10.2177\/jsci.30.55"},{"key":"bibr6-0961203319862867","first-page":"78","volume":"33","author":"Okano R","year":"1993","journal-title":"Rinsho Shinkeigaku [Clin Neurol]"},{"key":"bibr7-0961203319862867","doi-asserted-by":"publisher","DOI":"10.1177\/0961203313517155"},{"key":"bibr8-0961203319862867","doi-asserted-by":"publisher","DOI":"10.2169\/naika.101.2055"},{"key":"bibr9-0961203319862867","first-page":"119","volume":"15","author":"Yu W","year":"2012","journal-title":"Xianggang Fang She Ke Yi Xue Za Zhi [Hong Kong J Radiol]"},{"key":"bibr10-0961203319862867","doi-asserted-by":"publisher","DOI":"10.5692\/clinicalneurol.49.594"},{"key":"bibr11-0961203319862867","first-page":"119","volume":"24","author":"Lee YC","year":"2003","journal-title":"AJNR Am J Neuroradiol"},{"key":"bibr12-0961203319862867","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2006.11.020"},{"key":"bibr13-0961203319862867","doi-asserted-by":"publisher","DOI":"10.3342\/ceo.2011.4.3.155"},{"key":"bibr14-0961203319862867","first-page":"45","volume":"50","author":"Prabhakar S","year":"2002","journal-title":"Neurol India"},{"key":"bibr15-0961203319862867","doi-asserted-by":"publisher","DOI":"10.1053\/berh.2002.0259"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203319862867","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0961203319862867","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203319862867","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:21:11Z","timestamp":1777677671000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0961203319862867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,23]]},"references-count":15,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1177\/0961203319862867"],"URL":"https:\/\/doi.org\/10.1177\/0961203319862867","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,23]]}}}