{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:06:21Z","timestamp":1777928781025,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2019,9,7]],"date-time":"2019-09-07T00:00:00Z","timestamp":1567814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Guangzhou Scientific Project","award":["201803010042"],"award-info":[{"award-number":["201803010042"]}]},{"name":"Guangdong Technology Project","award":["2017A020215148"],"award-info":[{"award-number":["2017A020215148"]}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2018A0303130294"],"award-info":[{"award-number":["2018A0303130294"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81601403"],"award-info":[{"award-number":["81601403"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81603435"],"award-info":[{"award-number":["81603435"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the fetal adverse pregnancy outcomes (APOs) and the predictive value of umbilical arterial Doppler ultrasonography in the third trimester in pregnant women with lupus nephritis (LN).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study enrolling 203 LN patients from 2007 to 2017 was performed. Ultrasonic parameters were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fetal APOs occurred in 103 patients (103\/203, 50.7%). Sixty-six pregnancies (66\/203, 32.5%) ended with preterm births. The incidence rate of intrauterine growth restriction (IUGR) was 18.2% (37\/203). Fetal distress was noted in 23 pregnancies (23\/203, 11.3%). All the Doppler parameters elevated in patients with IUGR, fetal distress, and composite conditions. Resistance index (RI) indicated the highest risk of IUGR and composite APOs. The cutoff values were 0.66 and 0.67, respectively. Sensitivities were 51.4% and 33.7%, and specificities were 87.4% and 92.1%. Peak velocity of the umbilical arteries at end-systole (Vmax, abbreviated as S) to that at end-diastole (Vmin, abbreviated as D) (S\/D) ratio was also a best predictor for IUGR, with the optimal cutoff value of 2.88. Sensitivity and specificity were comparable with RI. Pulsatility index (PI) over 0.84 was an ideal indicator for fetal distress with an optimal combination of sensitivity (89.5%) and specificity (51.6%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Fetal complications were frequent in patients with LN. Umbilical arterial Doppler ultrasonography was a useful measure to predict late IUGR, fetal distress, and the composite APOs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0961203319873702","type":"journal-article","created":{"date-parts":[[2019,9,7]],"date-time":"2019-09-07T12:47:17Z","timestamp":1567860437000},"page":"1312-1319","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Umbilical arterial Doppler ultrasonography predicts late pregnancy outcomes in patients with lupus nephritis: a multicenter study from southern China"],"prefix":"10.1177","volume":"28","author":[{"given":"D","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Rheumatology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, South China University of Technology, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1757-572X","authenticated-orcid":false,"given":"M","family":"Lao","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"},{"name":"Department of Geriatrics, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, South China University of Technology, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,9,7]]},"reference":[{"key":"bibr1-0961203319873702","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.12441211"},{"key":"bibr2-0961203319873702","doi-asserted-by":"publisher","DOI":"10.1159\/000430458"},{"key":"bibr3-0961203319873702","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.100997"},{"key":"bibr4-0961203319873702","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00240110"},{"key":"bibr5-0961203319873702","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn348"},{"key":"bibr6-0961203319873702","doi-asserted-by":"publisher","DOI":"10.1177\/0961203315572715"},{"key":"bibr7-0961203319873702","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2016.06.016"},{"key":"bibr8-0961203319873702","doi-asserted-by":"publisher","DOI":"10.1177\/0961203312456893"},{"key":"bibr9-0961203319873702","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.6.599"},{"key":"bibr10-0961203319873702","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.06.038"},{"key":"bibr11-0961203319873702","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.22025"},{"key":"bibr12-0961203319873702","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0b013e3181fbb5f5"},{"key":"bibr13-0961203319873702","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"bibr14-0961203319873702","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780350606"},{"key":"bibr15-0961203319873702","first-page":"1056","volume":"95","author":"Obstetrics and Gynecology Section of the Chinese Medical Association","year":"2015","journal-title":"Natl Med J China"},{"key":"bibr16-0961203319873702","doi-asserted-by":"publisher","DOI":"10.1177\/0961203310388445"},{"key":"bibr17-0961203319873702","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1097\/01.AOG.0000437382.03963.88","volume":"122","author":"American College of Obstetricians and Gynecologists' Task Force on Hypertension in Pregnancy. 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