{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T02:40:58Z","timestamp":1793932858928,"version":"4.8.0"},"reference-count":15,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T00:00:00Z","timestamp":1569283200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000069","name":"NIAMS","doi-asserted-by":"crossref","award":["R01AR060849"],"award-info":[{"award-number":["R01AR060849"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p>Signal transducer and activator of transcription (STAT) 3 is a regulator of T-cell responses to external stimuli, such as pro-inflammatory cytokines and chemokines. We have previously shown that STAT3 is activated (phosphorylated) at high levels in systemic lupus erythematosus (SLE) T cells and mediates chemokine-induced migration and T:B cell interactions. Stattic, a small molecular STAT3 inhibitor, can partially ameliorate lupus nephritis in mice. To understand the role of STAT3 better in T-cell pathophysiology in lupus nephritis and its potential as a treatment target, we silenced its expression in T cells using a cd4-driven CRE-Flox model. We found that lupus-prone mice that do not express STAT3 in T cells did not develop lymphadenopathy, splenomegaly, or glomerulonephritis. Moreover, the production of anti-dsDNA antibodies was decreased in these mice compared to controls. To dissect the mechanism, we also used a nephrotoxic serum model of nephritis. In this model, T cell\u2013specific silencing of STAT3 resulted in amelioration of nephrotoxic serum-induced kidney damage. Taken together, our results suggest that in mouse models of autoimmune nephritis, T cell\u2013specific silencing of STAT3 can hamper their ability to help B cells to produce autoantibodies and induce cell tissue infiltration. We propose that STAT3 inhibition in T cells represents a novel approach in the treatment of SLE and lupus nephritis in particular.<\/jats:p>","DOI":"10.1177\/0961203319877242","type":"journal-article","created":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T20:54:58Z","timestamp":1569358498000},"page":"1468-1472","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":32,"title":["T cell\u2013specific STAT3 deficiency abrogates lupus nephritis"],"prefix":"10.1177","volume":"28","author":[{"given":"N","family":"Yoshida","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Beth Israel Deaconess Medical Center, Division of Rheumatology, Boston, USA"},{"name":"Harvard Medical School, Boston, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"He","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Beth Israel Deaconess Medical Center, Division of Rheumatology, Boston, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7652-3826","authenticated-orcid":false,"given":"V C","family":"Kyttaris","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Beth Israel Deaconess Medical Center, Division of Rheumatology, Boston, USA"},{"name":"Harvard Medical School, Boston, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,9,24]]},"reference":[{"key":"bibr1-0961203319877242","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3731"},{"key":"bibr2-0961203319877242","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1100359"},{"key":"bibr3-0961203319877242","doi-asserted-by":"publisher","DOI":"10.1177\/0961203307088307"},{"key":"bibr4-0961203319877242","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-8411(03)00121-5"},{"key":"bibr5-0961203319877242","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.4049\/jimmunol.130.6.2651","volume":"130","author":"Linker-Israeli M","year":"1983","journal-title":"J Immunol"},{"key":"bibr6-0961203319877242","doi-asserted-by":"publisher","DOI":"10.1080\/08916930601095148"},{"key":"bibr7-0961203319877242","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2015.04.004"},{"key":"bibr8-0961203319877242","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80005-9"},{"key":"bibr9-0961203319877242","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.90213.2008"},{"key":"bibr10-0961203319877242","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C600321200"},{"key":"bibr11-0961203319877242","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700418"},{"key":"bibr12-0961203319877242","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0801920"},{"key":"bibr13-0961203319877242","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32167-6"},{"key":"bibr14-0961203319877242","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2007.06.006"},{"key":"bibr15-0961203319877242","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31363-1"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203319877242","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0961203319877242","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203319877242","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:21:20Z","timestamp":1777677680000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0961203319877242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,24]]},"references-count":15,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1177\/0961203319877242"],"URL":"https:\/\/doi.org\/10.1177\/0961203319877242","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,24]]}}}