{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T13:08:48Z","timestamp":1793797728959,"version":"4.6.1"},"reference-count":44,"publisher":"SAGE Publications","issue":"13","license":[{"start":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T00:00:00Z","timestamp":1571184000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Consejo Nacional de Cienciay Tecnolog\u00eda","award":["255941, SEP-Ciencia B\u00e1sica 2015"],"award-info":[{"award-number":["255941, SEP-Ciencia B\u00e1sica 2015"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to analyze the expression of the high mobility group box-1 (HMGB1) protein in neutrophil extracellular traps (NETs) of patients with lupus nephritis (LN) and its association with clinical and histopathological features of the disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty-three patients with biopsy-confirmed LN and 14 systemic lupus erythematosus (SLE) patients with active disease (SLE Disease Activity Index (SLEDAI) score\u2009\u2265\u20096) and no evidence of LN were included. Clinical and laboratory features were recorded. NETs and the expression of HMGB1 were assessed by confocal microscopy, and serum HMGB1 levels were measured by ELISA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In comparison to patients without kidney disease, patients with LN had a higher expression of HMGB1 in spontaneous (57 vs. 30.4; p\u2009=\u20090.027) and lipopolysaccharide (LPS)-induced (55.8 vs. 24.9; p\u2009=\u20090.005) NETs. We found a positive correlation between serum HMGB1 and the expression of HMGB1 in LPS-induced NETs ( r\u2009=\u20090.447, p\u2009=\u20090.017). The expression of HMGB1 in spontaneous NETs correlated with SLEDAI score ( r\u2009=\u20090.514, p\u2009=\u20090.001), anti-dsDNA antibodies ( r\u2009=\u20090.467, p\u2009=\u20090.004), the rate of glomerular filtration descent ( r\u2009=\u20090.543, p\u2009=\u20090.001), and diverse histopathological components of active nephritis in the kidney biopsy, such as the activity index ( r\u2009=\u20090.581, p\u2009=\u20090.004), fibrinoid necrosis ( r\u2009=\u20090.603, p\u2009=\u20090.002), and cellular crescents ( r\u2009=\u20090.486, p\u2009=\u20090.019).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with SLE, NETs are a source of extracellular HMGB1. The expression of HMGB1 in NETs is higher among patients with LN, which correlates with clinical and histopathological features of active nephritis and suggest a possible role of this alarmin in the pathophysiology of kidney damage in SLE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0961203319883936","type":"journal-article","created":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T01:57:11Z","timestamp":1571277431000},"page":"1549-1557","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":42,"title":["Neutrophil extracellular traps are a source of extracellular HMGB1 in lupus nephritis: associations with clinical and histopathological features"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5762-4469","authenticated-orcid":false,"given":"L P","family":"Whittall-Garc\u00eda","sequence":"first","affiliation":[{"name":"Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Torres-Ruiz","sequence":"additional","affiliation":[{"name":"Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico"},{"name":"Emergency Medicine Department, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Zentella-Dehesa","sequence":"additional","affiliation":[{"name":"Department of Genomic Medicine and Environmental Toxicology, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Tapia-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Microscopy Unit, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Alcocer-Varela","sequence":"additional","affiliation":[{"name":"Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Mendez-Huerta","sequence":"additional","affiliation":[{"name":"Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"G\u00f3mez-Mart\u00edn","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico"},{"name":"Flow Cytometry Unit, Red de Apoyo a la Investigaci\u00f3n. Coordinaci\u00f3n de Investigaci\u00f3n Cient\u00edfica, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,10,16]]},"reference":[{"key":"bibr1-0961203319883936","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.135186"},{"key":"bibr2-0961203319883936","doi-asserted-by":"publisher","DOI":"10.1016\/j.reuma.2010.11.001"},{"key":"bibr3-0961203319883936","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100450"},{"key":"bibr4-0961203319883936","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3001201"},{"key":"bibr5-0961203319883936","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2011.132"},{"key":"bibr6-0961203319883936","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-018-0039-z"},{"key":"bibr7-0961203319883936","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.05.057"},{"key":"bibr8-0961203319883936","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201719"},{"key":"bibr9-0961203319883936","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092385"},{"key":"bibr10-0961203319883936","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2011.222"},{"key":"bibr11-0961203319883936","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-009-9485-7"},{"key":"bibr12-0961203319883936","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20120189"},{"key":"bibr13-0961203319883936","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5179"},{"key":"bibr14-0961203319883936","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1212662"},{"key":"bibr15-0961203319883936","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2008.08.007"},{"key":"bibr16-0961203319883936","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090663"},{"key":"bibr17-0961203319883936","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2015.01.023"},{"key":"bibr18-0961203319883936","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2015.0082"},{"key":"bibr19-0961203319883936","doi-asserted-by":"publisher","DOI":"10.1186\/ar3747"},{"key":"bibr20-0961203319883936","doi-asserted-by":"publisher","DOI":"10.1186\/ar4015"},{"key":"bibr21-0961203319883936","doi-asserted-by":"publisher","DOI":"10.1177\/0961203316644331"},{"key":"bibr22-0961203319883936","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0856-2"},{"key":"bibr23-0961203319883936","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics5020219"},{"key":"bibr24-0961203319883936","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-010-1636-6"},{"key":"bibr25-0961203319883936","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-44379-w"},{"key":"bibr26-0961203319883936","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/41.9.1040"},{"key":"bibr27-0961203319883936","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"bibr28-0961203319883936","doi-asserted-by":"publisher","DOI":"10.1002\/art.34473"},{"key":"bibr29-0961203319883936","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20572"},{"key":"bibr30-0961203319883936","doi-asserted-by":"publisher","DOI":"10.1016\/j.conctc.2018.100309"},{"key":"bibr31-0961203319883936","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2017.85"},{"key":"bibr32-0961203319883936","doi-asserted-by":"publisher","DOI":"10.1002\/cpim.16"},{"key":"bibr33-0961203319883936","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204837"},{"key":"bibr34-0961203319883936","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2016.71"},{"key":"bibr35-0961203319883936","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.12433"},{"key":"bibr36-0961203319883936","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.53.2570"},{"key":"bibr37-0961203319883936","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1203301"},{"key":"bibr38-0961203319883936","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12951"},{"key":"bibr39-0961203319883936","doi-asserted-by":"publisher","DOI":"10.1186\/ar3332"},{"key":"bibr40-0961203319883936","doi-asserted-by":"publisher","DOI":"10.1038\/ni1457"},{"key":"bibr41-0961203319883936","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2015.04.013"},{"key":"bibr42-0961203319883936","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.24071"},{"key":"bibr43-0961203319883936","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900742"},{"key":"bibr44-0961203319883936","doi-asserted-by":"crossref","unstructured":"van Dam LS, Kraaij T, Kamerling SWA, et\u00a0al. Neutrophil extracellular trap formation is intrinsically distinct in ANCA-associated vasculitis and systemic lupus erythematosus.\n                      Arthritis Rheumatol\n                      . Epub ahead of print 16 July 2019 2019. 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