{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:06:30Z","timestamp":1777928790293,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"14","license":[{"start":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T00:00:00Z","timestamp":1572825600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"ENABLE grant through the Duke University Private Diagnostic Clinic (PDC) and Department of Medicine"},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL118049"],"award-info":[{"award-number":["R01 HL118049"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Duke University CTSA","award":["UL1TR002553"],"award-info":[{"award-number":["UL1TR002553"]}]},{"DOI":"10.13039\/100000980","name":"Arthritis Foundation","doi-asserted-by":"publisher","award":["Arthritis Investigator Award"],"award-info":[{"award-number":["Arthritis Investigator Award"]}],"id":[{"id":"10.13039\/100000980","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Women with lupus have an increased risk of preeclampsia and preterm birth, and aspirin 81\u2009mg\/day is recommended as a preventative measure for preeclampsia. This pilot study quantified the association between a 60-gene aspirin response signature (ARS) gene expression with preterm birth and preeclampsia risk among women with lupus taking aspirin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The analysis included 48 RNA samples from 23 pregnancies in the Duke Autoimmunity Pregnancy Registry. RNA was isolated from peripheral blood, and quantitative polymerase chain reaction was performed for ARS genes. The primary outcome was poor pregnancy outcome (preeclampsia or preterm birth). Gene expression was modeled as a response to presence or absence of a poor pregnancy outcome using linear regression models, stratified by trimester.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 23 pregnancies, nine delivered preterm and four had preeclampsia. Expression of PBX1 and MMD was higher in the second trimester among patients who experienced a poor pregnancy outcome compared to those who did not. However, in a global test of all ARS genes, we identified no association between expression of ARS genes and poor pregnancy outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our pilot study identified two candidate genes that are reflective of the platelet function response to aspirin. Further work is needed to determine the role of these genes in identifying women with lupus at high risk for preeclampsia and preterm delivery despite aspirin therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0961203319886069","type":"journal-article","created":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T02:26:52Z","timestamp":1572920812000},"page":"1640-1647","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of aspirin response signature gene expression on preterm birth and preeclampsia among women with lupus: a pilot study"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3107-5545","authenticated-orcid":false,"given":"A M","family":"Eudy","sequence":"first","affiliation":[{"name":"Division of Rheumatology & Immunology, Duke University School of Medicine, Durham, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Voora","sequence":"additional","affiliation":[{"name":"Duke Center for Applied Genomics & Precision Medicine, Duke University, Durham, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R A","family":"Myers","sequence":"additional","affiliation":[{"name":"Duke Center for Applied Genomics & Precision Medicine, Duke University, Durham, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M E B","family":"Clowse","sequence":"additional","affiliation":[{"name":"Division of Rheumatology & Immunology, Duke University School of Medicine, Durham, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,11,4]]},"reference":[{"key":"bibr1-0961203319886069","doi-asserted-by":"publisher","DOI":"10.1002\/art.21663"},{"key":"bibr2-0961203319886069","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.03.012"},{"key":"bibr3-0961203319886069","doi-asserted-by":"publisher","DOI":"10.1177\/0961203316686704"},{"key":"bibr4-0961203319886069","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2017.02.009"},{"key":"bibr5-0961203319886069","doi-asserted-by":"publisher","DOI":"10.1177\/0961203317720525"},{"key":"bibr6-0961203319886069","doi-asserted-by":"crossref","unstructured":"Chaudhary P, Clowse M. Systemic lupus erythematosus in the pregnant patient and neonatal lupus. In: Hochberg MC (ed)\n                      Rheumatology\n                      . Maryland Heights, MO: Mosby\/Elsevier, 2015, pp.1127-1130.","DOI":"10.1016\/B978-0-323-09138-1.00137-6"},{"key":"bibr7-0961203319886069","doi-asserted-by":"publisher","DOI":"10.7326\/M14-1884"},{"key":"bibr8-0961203319886069","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001115"},{"key":"bibr9-0961203319886069","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12421"},{"key":"bibr10-0961203319886069","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198908103210603"},{"key":"bibr11-0961203319886069","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.675587"},{"key":"bibr12-0961203319886069","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2014.930428"},{"key":"bibr13-0961203319886069","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(16)34346-8"},{"key":"bibr14-0961203319886069","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70163-8"},{"key":"bibr15-0961203319886069","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2011.02.026"},{"key":"bibr16-0961203319886069","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.05.073"},{"key":"bibr17-0961203319886069","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"bibr18-0961203319886069","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780251101"},{"key":"bibr19-0961203319886069","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2016.08.021"},{"key":"bibr20-0961203319886069","doi-asserted-by":"publisher","DOI":"10.1002\/art.39029"},{"key":"bibr21-0961203319886069","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2017.12.052"},{"key":"bibr22-0961203319886069","first-page":"1","volume":"19","author":"Dretzke J","year":"2015","journal-title":"Health Technol Assess"},{"key":"bibr23-0961203319886069","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-012-0217-x"},{"key":"bibr24-0961203319886069","doi-asserted-by":"publisher","DOI":"10.1177\/0961203313493487"},{"key":"bibr25-0961203319886069","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.111.964627"},{"key":"bibr26-0961203319886069","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13500"},{"key":"bibr27-0961203319886069","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078093"},{"key":"bibr28-0961203319886069","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2017.10.004"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203319886069","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0961203319886069","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203319886069","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:21:33Z","timestamp":1777677693000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0961203319886069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,4]]},"references-count":28,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1177\/0961203319886069"],"URL":"https:\/\/doi.org\/10.1177\/0961203319886069","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,4]]}}}