{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:00:31Z","timestamp":1790352031063,"version":"4.1.0"},"reference-count":41,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T00:00:00Z","timestamp":1575417600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We analyzed baseline and follow-up characteristics related to poorer renal outcomes in a Brazilian cohort of admixture race patients with lupus nephritis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Overall, 280 outpatients with a diagnosis of systemic lupus erythematosus and previous kidney biopsy of lupus nephritis were recruited from August 2015 to December 2018 and had baseline laboratory and histologic data retrospectively analyzed; patients were then followed-up and data were recorded. The main outcome measure was the estimated glomerular filtration rate at last follow-up. Secondary analyses assessed the impact of initial kidney histology and treatment in long-term kidney survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median duration of lupus nephritis was 60 months (interquartile range: 27\u2013120); 40 (14.3%) patients presented progressive chronic kidney disease (estimated glomerular filtration rate &lt;30 and \u226510\u2009ml\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      ) or end-stage kidney disease at last visit. Adjusted logistic regression analysis showed that class IV lupus nephritis (odds ratio 14.91; 95% confidence interval 1.77\u2013125.99; p\u2009=\u20090.01) and interstitial fibrosis \u226525% at initial biopsy (odds ratio 5.87; 95% confidence interval 1.32\u201326.16; p\u2009=\u20090.02), lack of complete or partial response at 12 months (odds ratio 16.3; 95% confidence interval 3.74\u201371.43; p\u2009&lt;\u20090.001), and a second renal flare (odds ratio 4.49; 95% confidence interval 1.10\u201318.44; p\u2009=\u20090.04) were predictors of progressive chronic kidney disease. In a Kaplan-Meier survival curve we found that class IV lupus nephritis and interstitial fibrosis \u226525% were significantly associated with end-stage kidney disease throughout follow-up (hazard ratio 2.96; 95% confidence interval 1.3\u20137.0; p\u2009=\u20090.036 and hazard ratio 4.96; 95% confidence interval 1.9\u201312.9; p\u2009&lt;\u20090.0001, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this large cohort of admixture race patients, class IV lupus nephritis and chronic interstitial damage at initial renal biopsy together with non-response after 1 year of therapy and relapse were associated with worse long-term renal outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0961203319890681","type":"journal-article","created":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T19:55:36Z","timestamp":1575489336000},"page":"83-91","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Initial renal histology and early response predict outcomes of Brazilian lupus nephritis patients"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2606-3638","authenticated-orcid":false,"given":"G","family":"Vajgel","sequence":"first","affiliation":[{"name":"Division of Nephrology, Hospital das Clinicas, Federal University of Pernambuco, Recife, Brazil"},{"name":"Molecular Biology Laboratory, Keizo Asami Immunopathology Laboratory, Federal University of Pernambuco, Recife, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2080-923X","authenticated-orcid":false,"given":"C B 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M","family":"Valente","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Hospital das Clinicas, Federal University of Pernambuco, Recife, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Sesso","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Crovella","sequence":"additional","affiliation":[{"name":"Molecular Biology Laboratory, Keizo Asami Immunopathology Laboratory, Federal University of Pernambuco, Recife, Brazil"},{"name":"Department of Genetics, Federal University of Pernambuco, Recife, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G M","family":"Kirsztajn","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Sandrin-Garcia","sequence":"additional","affiliation":[{"name":"Molecular Biology Laboratory, Keizo Asami Immunopathology Laboratory, Federal University of Pernambuco, Recife, Brazil"},{"name":"Department of Genetics, Federal University of Pernambuco, Recife, 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