{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T12:11:10Z","timestamp":1792757470047,"version":"4.5.0"},"reference-count":78,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T00:00:00Z","timestamp":1576108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:p>Antiphospholipid syndrome is a systemic autoimmune disease associated with obstetric complications along with vascular events affecting multiple organ systems in patients having positive titers of antiphospholipid antibodies. Eight to 20% of infertility cases have an unknown cause, part of which could be due to antiphospholipid syndrome. Although still debatable, many studies have addressed the relation between reproductive failure and antiphospholipid antibodies through the relation between antiphospholipid antibodies and unexplained infertility as well as the effect of antiphospholipid antibodies on the outcome of in\u00a0vitro fertilization\u2013embryo transfer. Few studies and cases have associated the presence of antiphospholipid antibodies with male infertility, describing morphofunctional penile abnormalities and testicular infarction. There are not enough data to support the routine practice of testing antiphospholipid antibodies in patients with infertility.<\/jats:p>","DOI":"10.1177\/0961203319893763","type":"journal-article","created":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T07:02:03Z","timestamp":1576134123000},"page":"105-117","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["Antiphospholipid syndrome and infertility"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2571-1450","authenticated-orcid":false,"given":"G","family":"El Hasbani","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Khamashta","sequence":"additional","affiliation":[{"name":"London Lupus Centre, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Uthman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,12,12]]},"reference":[{"key":"bibr1-0961203319893763","doi-asserted-by":"crossref","DOI":"10.1111\/j.1538-7836.2006.01753.x","volume":"4","author":"Miyakis S","year":"2006","journal-title":"J Thromb Haemost"},{"key":"bibr2-0961203319893763","doi-asserted-by":"crossref","DOI":"10.1007\/s11926-017-0663-7","volume":"19","author":"Chighizola CB","year":"2017","journal-title":"Curr Rheumatol Rep"},{"key":"bibr3-0961203319893763","volume":"183","author":"Pattison NS","year":"2000","journal-title":"In: Am J Obstetrics Gynecol"},{"key":"bibr4-0961203319893763","doi-asserted-by":"crossref","DOI":"10.1016\/j.humimm.2012.04.003","volume":"73","author":"Kov\u00e1cs M","year":"2012","journal-title":"Hum Immunol"},{"key":"bibr5-0961203319893763","doi-asserted-by":"crossref","DOI":"10.1007\/s12016-016-8586-z","volume":"53","author":"Deroux A","year":"2017","journal-title":"Clin Rev Allergy Immunol"},{"key":"bibr6-0961203319893763","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2016.01.018","volume":"15","author":"Chighizola CB","year":"2016","journal-title":"Autoimmun Rev"},{"key":"bibr7-0961203319893763","volume":"41","author":"Out HJ","year":"1991","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"bibr8-0961203319893763","doi-asserted-by":"crossref","DOI":"10.1038\/nm1121","volume":"10","author":"Girardi G","year":"2004","journal-title":"Nat Med"},{"key":"bibr9-0961203319893763","volume":"18","author":"Lim W","year":"2011","journal-title":"Curr Opin Hematol"},{"key":"bibr10-0961203319893763","doi-asserted-by":"crossref","DOI":"10.1093\/humupd\/dmn013","volume":"14","author":"Cervera R","year":"2008","journal-title":"Hum Reprod Update"},{"key":"bibr11-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(11)90700-5"},{"key":"bibr12-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1084\/jem.200116116"},{"key":"bibr13-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200318817"},{"key":"bibr14-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gal048"},{"key":"bibr15-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1005743107"},{"key":"bibr16-0961203319893763","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.142471"},{"key":"bibr17-0961203319893763","doi-asserted-by":"crossref","unstructured":"Hahn S, Hasler P, Vokalova L, et al. The role of neutrophil activation in determining the outcome of pregnancy and modulation by hormones and\/or cytokines.\n                      Clin Exp Immunol\n                      2019; 198: 24\u201336.","DOI":"10.1111\/cei.13278"},{"key":"bibr18-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.06.005"},{"key":"bibr19-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(89)90858-2"},{"key":"bibr20-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90023-3"},{"key":"bibr21-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(89)90524-3"},{"key":"bibr22-0961203319893763","first-page":"415","volume":"35","author":"Roussev RG","year":"1996","journal-title":"Am J Reprod Immunol N Y N 1989"},{"key":"bibr23-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)58040-6"},{"key":"bibr24-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022588903620"},{"key":"bibr25-0961203319893763","first-page":"119","volume":"3","author":"Cubillos J","year":"1997","journal-title":"Early Pregnancy Biol Med Off J Soc Investig Early Pregnancy"},{"key":"bibr26-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/12.6.1171"},{"key":"bibr27-0961203319893763","doi-asserted-by":"crossref","first-page":"91","DOI":"10.33549\/physiolres.930405","volume":"53","author":"Radojci\u0107 L","year":"2004","journal-title":"Physiol Res"},{"key":"bibr28-0961203319893763","first-page":"337","volume":"56","author":"Shoenfeld Y","year":"2006","journal-title":"Am J Reprod Immunol N Y N 1989"},{"key":"bibr29-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.08.062"},{"key":"bibr30-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-200103000-00005"},{"key":"bibr31-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a135746"},{"key":"bibr32-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1996.tb00502.x"},{"key":"bibr33-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1998.tb00349.x"},{"key":"bibr34-0961203319893763","first-page":"789","volume":"88","author":"Martinelli I","year":"2003","journal-title":"Haematologica"},{"key":"bibr35-0961203319893763","first-page":"163","volume":"70","author":"el-Roeiy A","year":"1987","journal-title":"Obstet Gynecol"},{"key":"bibr36-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)54605-6"},{"key":"bibr37-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)57008-3"},{"key":"bibr38-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1994.tb00848.x"},{"key":"bibr39-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a135745"},{"key":"bibr40-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a019095"},{"key":"bibr41-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1996.tb00499.x"},{"key":"bibr42-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(98)00312-4"},{"key":"bibr43-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1999.tb00110.x"},{"key":"bibr44-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2005.00294.x"},{"key":"bibr45-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1422.048"},{"key":"bibr46-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2006.00374.x"},{"key":"bibr47-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2006.00437.x"},{"key":"bibr48-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2011.01058.x"},{"key":"bibr49-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2017.08.002"},{"key":"bibr50-0961203319893763","doi-asserted-by":"crossref","unstructured":"Khizroeva J, Makatsariya A, Bitsadze V, Makatsariya N, Khamani N. In\u00a0vitro fertilization outcomes in women with antiphospholipid antibodies circulation.\n                      J Matern-Fetal Neonatal Med Off J Eur Assoc Perinat Med Fed Asia Ocean Perinat Soc Int Soc Perinat Obstet\n                      October 2018; 12: 1\u201311.","DOI":"10.1080\/14767058.2018.1535586"},{"key":"bibr51-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a138437"},{"key":"bibr52-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(94)70110-5"},{"key":"bibr53-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a019352"},{"key":"bibr54-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(97)81443-4"},{"key":"bibr55-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(97)81519-1"},{"key":"bibr56-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/14.6.1483"},{"key":"bibr57-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/14.6.1461"},{"key":"bibr58-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01612.x"},{"key":"bibr59-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del203"},{"key":"bibr60-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dei369"},{"key":"bibr61-0961203319893763","first-page":"172","author":"Practice Committee of American Society for Reproductive Medicine","year":"2008","journal-title":"Fertil Steril"},{"key":"bibr62-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem179"},{"key":"bibr63-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1160\/TH12-06-0381"},{"key":"bibr64-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.02.003"},{"key":"bibr65-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2012.04.002"},{"key":"bibr66-0961203319893763","doi-asserted-by":"crossref","first-page":"789","DOI":"10.7727\/wimj.2012.275","volume":"61","author":"DaCosta V","year":"2012","journal-title":"West Indian Med J"},{"key":"bibr67-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/314704"},{"key":"bibr68-0961203319893763","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.160462"},{"key":"bibr69-0961203319893763","doi-asserted-by":"publisher","DOI":"10.5468\/ogs.2018.61.3.359"},{"key":"bibr70-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2018.05.006"},{"key":"bibr71-0961203319893763","doi-asserted-by":"crossref","DOI":"10.1055\/s-0030-1270071","volume":"37","author":"Mehdi AA","year":"2011","journal-title":"Semin Thromb Hemost"},{"key":"bibr72-0961203319893763","volume":"21","author":"Rabelo-J\u00fanior CN","year":"2012","journal-title":"Lupus"},{"key":"bibr73-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-012-2083-4"},{"key":"bibr74-0961203319893763","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1995.14.1.57"},{"key":"bibr75-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1191\/096120301669209574"},{"key":"bibr76-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/17.3.516"},{"key":"bibr77-0961203319893763","first-page":"707","volume":"57","author":"Fern\u00e1ndez Rosado E","year":"2004","journal-title":"Arch Esp Urol"},{"key":"bibr78-0961203319893763","doi-asserted-by":"publisher","DOI":"10.1016\/j.eucr.2017.08.010"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203319893763","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0961203319893763","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0961203319893763","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:21:40Z","timestamp":1777677700000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0961203319893763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,12]]},"references-count":78,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1177\/0961203319893763"],"URL":"https:\/\/doi.org\/10.1177\/0961203319893763","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,12]]}}}