{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:06:48Z","timestamp":1777928808514,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T00:00:00Z","timestamp":1582070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"National Key R&D Programs of China","award":["2017YFA0105204"],"award-info":[{"award-number":["2017YFA0105204"]}]},{"name":"National Key R&D Programs of China","award":["2017YFC1103603"],"award-info":[{"award-number":["2017YFC1103603"]}]},{"name":"CAMS Initiative for Innovative Medicine of China","award":["2016-12M-1-006"],"award-info":[{"award-number":["2016-12M-1-006"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Systemic lupus erythematosus (SLE) patients experience a premature and more severe presentation of coronary artery disease. The underlying mechanisms of accelerated coronary artery disease in SLE patients remain to be elucidated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>By using atherosclerosis combining a SLE murine model, we proved that the onset of SLE aggravates atherosclerosis. Although the onset of SLE reduced blood lipids slightly, immune deviation contributed to aggravated atherosclerosis in lupus mice. Lupus atheroma were characterized by inflammatory cell infiltration, such as gathered dendritic cells, macrophages, and IgG deposition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Decreased lymphocytes and magnified dendritic cells in the spleen were also observed in lupus mice. Hydroxychloroquine prevented atherosclerosis progression mainly by reversing immune status abnormality caused by SLE. Serum interferon alfa levels were not changed in lupus mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings strongly suggested that anti-inflammatory therapies and hydroxychloroquine provide a new possible strategy for treating SLE patients with atherosclerosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0961203320904779","type":"journal-article","created":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T00:27:25Z","timestamp":1582158445000},"page":"273-282","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Systemic lupus erythematosus aggravates atherosclerosis by promoting IgG deposition and inflammatory cell imbalance"],"prefix":"10.1177","volume":"29","author":[{"given":"T","family":"Liu","sequence":"first","affiliation":[{"name":"NHC Key Laboratory of Human Disease Comparative Medicine, The Institute of Laboratory Animal Sciences, Beijing, China"},{"name":"Department of Cardiology, Peking Union Medical College Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Shi","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Human Disease Comparative Medicine, The Institute of Laboratory Animal Sciences, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Medicine, Jinan University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G J","family":"Silverman","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Langone Medical Center, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X-W","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, the Second Affiliated Hospital of Nanchang University, Nanchang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Peking Union Medical College Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4473-1297","authenticated-orcid":false,"given":"H","family":"Niu","sequence":"additional","affiliation":[{"name":"School of Medicine, Jinan University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,2,19]]},"reference":[{"key":"bibr1-0961203320904779","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2014.01.021"},{"key":"bibr2-0961203320904779","first-page":"382","volume":"40","author":"Yang J","year":"2012","journal-title":"Zhonghua Xin Xue Guan Bing Za Zhi"},{"key":"bibr3-0961203320904779","first-page":"753","volume":"42","author":"Liu 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