{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:20:17Z","timestamp":1790018417614,"version":"4.0.1"},"reference-count":47,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2020,2,16]],"date-time":"2020-02-16T00:00:00Z","timestamp":1581811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100009573","name":"Universidad Nacional de Rosario","doi-asserted-by":"crossref","award":["PID UNR 1MED434"],"award-info":[{"award-number":["PID UNR 1MED434"]}],"id":[{"id":"10.13039\/100009573","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ministerio de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n Productiva de la Provincia de Santa Fe","award":["ID 2010-116-14"],"award-info":[{"award-number":["ID 2010-116-14"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:p>Lupus nephropathy is a severe and frequent complication of systemic lupus erythematosus. Here, we assessed the biomarkers of oxidative stress, inflammation and disease activity in patients with lupus nephritis. Thirty-four patients with active lupus nephritis, 31 patients with inactive lupus nephritis and 20 lupus patients without renal damage (non-lupus nephritis) were studied. Oxidative stress biomarkers malonyldialdehyde, oxidized-to-total glutathione, catalase, superoxide dismutase and total antioxidant status were assessed, as well as inflammation biomarkers CRP, interleukin 6 and monocyte chemoattractant protein 1. Renal tubular disease biomarkers neutrophil gelatinase-associated lipocalin and \u03b22-microglobulin were assessed, together with the classic disease activity biomarkers urinary protein\/creatinine ratio, anti-dsDNA, anti-C1q antibody and complement proteins C3 and C4. Significant differences were found between active lupus nephritis and inactive lupus nephritis patients and between active lupus nephritis and non-lupus nephritis patients for all the assessed biomarkers ( P\u2009&lt;\u20090.05), except for catalase, superoxide dismutase and interleukin 6. There is an imbalance in the redox status in active lupus nephritis patients that would be involved in lipid peroxidation of the glomerular basal membrane that would alter its integrity and could also affect renal tubular function in these patients.<\/jats:p>","DOI":"10.1177\/0961203320904784","type":"journal-article","created":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T00:22:15Z","timestamp":1581898935000},"page":"311-323","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":45,"title":["Oxidative stress, inflammation and disease activity biomarkers in lupus nephropathy"],"prefix":"10.1177","volume":"29","author":[{"given":"N","family":"Bona","sequence":"first","affiliation":[{"name":"Area Bioqu\u00edmica Cl\u00ednica, Facultad de Ciencias Bioqu\u00edmicas y Farmac\u00e9uticas, Rosario, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Pezzarini","sequence":"additional","affiliation":[{"name":"Area Bioqu\u00edmica Cl\u00ednica, Facultad de Ciencias Bioqu\u00edmicas y Farmac\u00e9uticas, Rosario, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Balbi","sequence":"additional","affiliation":[{"name":"Area Bioqu\u00edmica Cl\u00ednica, Facultad de Ciencias Bioqu\u00edmicas y Farmac\u00e9uticas, Rosario, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S M","family":"Daniele","sequence":"additional","affiliation":[{"name":"Area Bioqu\u00edmica Cl\u00ednica, Facultad de Ciencias Bioqu\u00edmicas y Farmac\u00e9uticas, Rosario, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M F","family":"Rossi","sequence":"additional","affiliation":[{"name":"Area Bioqu\u00edmica Cl\u00ednica, Facultad de Ciencias Bioqu\u00edmicas y Farmac\u00e9uticas, Rosario, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A L","family":"Monje","sequence":"additional","affiliation":[{"name":"\u00c1rea Cl\u00ednica M\u00e9dica, Facultad de Ciencias M\u00e9dicas, Rosario, Argentina"},{"name":"Carrera Universitaria de Nefrolog\u00eda, Facultad de Ciencias M\u00e9dicas, Rosario, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7321-4208","authenticated-orcid":false,"given":"CL","family":"Basiglio","sequence":"additional","affiliation":[{"name":"Area Bioqu\u00edmica Cl\u00ednica, Facultad de Ciencias Bioqu\u00edmicas y Farmac\u00e9uticas, Rosario, Argentina"},{"name":"Instituto de Fisiolog\u00eda Experimental (IFISE-CONICET), Facultad de Ciencias Bioqu\u00edmicas y Farmac\u00e9uticas, Rosario, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H F","family":"Pelusa","sequence":"additional","affiliation":[{"name":"Area Bioqu\u00edmica Cl\u00ednica, Facultad de Ciencias Bioqu\u00edmicas y Farmac\u00e9uticas, Rosario, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S M M","family":"Arriaga","sequence":"additional","affiliation":[{"name":"Area Bioqu\u00edmica Cl\u00ednica, Facultad de Ciencias Bioqu\u00edmicas y Farmac\u00e9uticas, Rosario, Argentina"},{"name":"Consejo de Investigaciones de la Universidad Nacional de Rosario (CIUNR). Universidad Nacional de Rosario. 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